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Dstn
Gene Detail
 Symbol
Name
ID
Dstn
destrin
MGI:1929270
Synonyms 2610043P17Rik, ADF, corn1, sid23p
Feature Type protein coding gene
Genetic Map
Chromosome 2
70.89 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:143915320-143943324 bp, + strand
From VEGA annotation of GRCm38

  28005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21362  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ADF/cofilin
Gene Tree: Dstn

Human
homologs
Human Homolog DSTN, destrin (actin depolymerizing factor)
NCBI Gene ID 11034
neXtProt AC  NX_P60981
Human Synonyms  ACTDP, ADF, bA462D18.2, HEL32
Human Chr (Location)  20p12.1; chr20:17569954-17608007 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(73) Spontaneous(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice carrying mutations at this locus develop irregular thickening of the corneal epithelium.
 
Phenotype Images(1)
Interactions
Dstn interacts with 156 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process actin filament depolymerization, cellular component movement, ...
Component actin cytoskeleton, cortical actin cytoskeleton, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (242)    Tissues (37)    Images (22)
Theiler Stages: 15, 19, 22, 23
Assay TypeResults
RNA in situ 242
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003226 (Evidence)
Ensembl Gene ModelENSMUSG00000015932 (Evidence)
Entrez Gene56431 (Evidence)
DFCITC1572287, TC1632648
DoTSDT.87072784, DT.97410038
NIA Mouse Gene IndexU002562, U365256, U373004
Consensus CDS ProjectCCDS16812.1
International Mouse Knockout Project StatusDstn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003226 VEGA Gene Model | MGI Sequence Detail 28005 C57BL/6J ±  kb
transcript OTTMUST00000006695 VEGA | MGI Sequence Detail 1911 Not Applicable 
polypeptide OTTMUSP00000003185 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(277 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR017904 ADF/Cofilin/Destrin
Protein Ontology PR:000006713 destrin
References (Earliest) J:31798 Smith RS, et al., Corn1: a mouse model for corneal surface disease and neovascularization. Invest Ophthalmol Vis Sci. 1996 Feb;37(2):397-404
(Latest) J:208758 Kawakami-Schulz SV, et al., Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea. Physiol Genomics. 2014 Apr 15;46(8):277-89
All references(61)
Other
accession IDs
MGD-MRK-33921, MGI:106229, MGI:1917157, MGI:2139214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory