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Dstn
Gene Detail
Symbol

Name
ID
Dstn
destrin
MGI:1929270
Synonyms
2610043P17Rik, ADF, corn1, sid23p
Feature Type
protein coding gene
Genetic Map
Chromosome 2
70.89 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:143915320-143943324 bp, + strand
From VEGA annotation of GRCm38

  28005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21362  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: DSTN
Protein SuperFamily: ADF/cofilin
Gene Tree: Dstn

Human
homologs
DSTN, destrin (actin depolymerizing factor)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11034
neXtProt AC: NX_P60981

Human Synonyms: ACTDP, ADF, bA462D18.2, HEL32

Human Chr (Location): 20p12.1; chr20:17569173-17608242 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(73) Spontaneous(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice carrying mutations at this locus develop irregular thickening of the corneal epithelium.
 
Phenotype Images(1)
Interactions
Dstn interacts with 156 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process actin filament depolymerization, actin filament severing, ...
Component actin cytoskeleton, cortical actin cytoskeleton, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (242)    Tissues (37)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 242
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dstn    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000003226 (Evidence)
Ensembl Gene Model ENSMUSG00000015932 (Evidence)
Entrez Gene 56431 (Evidence)
DFCI TC1632648, TC1572287
DoTS DT.97410038, DT.87072784
NIA Mouse Gene Index U365256, U002562, U373004
Consensus CDS Project CCDS16812.1
International Mouse Phenotyping Consortium Status Dstn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003226 VEGA Gene Model | MGI Sequence Detail 28005 C57BL/6J ±  kb
transcript OTTMUST00000006695 VEGA | MGI Sequence Detail 1911 Not Applicable 
polypeptide OTTMUSP00000003185 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(277 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
InterPro IPR017904 ADF/Cofilin/Destrin
Protein Ontology PR:000006713 destrin
References
(Earliest) J:31798 Smith RS, et al., Corn1: a mouse model for corneal surface disease and neovascularization. Invest Ophthalmol Vis Sci. 1996 Feb;37(2):397-404
(Latest) J:208758 Kawakami-Schulz SV, et al., Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea. Physiol Genomics. 2014 Apr 15;46(8):277-89
All references(61)
Other
accession IDs
MGD-MRK-33921, MGI:106229, MGI:1917157, MGI:2139214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory