Dstn
Gene Detail

Symbol Name ID

Dstn destrin MGI:1929270

Synonyms

2610043P17Rik, ADF, corn1, sid23p

Feature Type

protein coding gene

Genetic Map

Chromosome 2

70.89 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:143915320-143943324 bp, + strand From VEGA annotation of GRCm38   28005 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21362  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ADF/cofilin
Gene Tree: Dstn

Human homologs

Human Homolog		DSTN, destrin (actin depolymerizing factor)
NCBI Gene ID		11034
neXtProt AC		NX_P60981
Human Synonyms		ACTDP, ADF, bA462D18.2
Human Chr (Location)		20p12.1; chr20:17550599-17588652 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(78) : Targeted(3) Gene trapped(73) Spontaneous(2)
 

Mice carrying mutations at this locus develop irregular thickening of the corneal epithelium.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	actin filament depolymerization, cellular component movement, ...
Component	actin cytoskeleton, cortical actin cytoskeleton, ...
Function	actin binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (242)    Tissues (37)    Images (22)
Theiler Stages: 15, 19, 22, 23

Assay Type	Results
RNA in situ	242

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(11) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003226 (Evidence)
Ensembl Gene Model	ENSMUSG00000015932 (Evidence)
Entrez Gene	56431 (Evidence)
DFCI	TC1572287, TC1632648
DoTS	DT.87072784, DT.97410038
NIA Mouse Gene Index	U002562, U365256, U373004
Consensus CDS Project	CCDS16812.1
International Mouse Knockout Project Status	Dstn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003226	VEGA Gene Model | MGI Sequence Detail	28005	C57BL/6J
transcript	OTTMUST00000006695	VEGA | MGI Sequence Detail	1911	Not Applicable
polypeptide	OTTMUSP00000003185	VEGA | MGI Sequence Detail	165	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(164 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002108	Actin-binding, cofilin/tropomyosin type
InterPro	IPR017904	ADF/Cofilin/Destrin
Protein Ontology	PR:000006713	destrin

References

(Earliest) J:31798 Smith RS, et al., Corn1: a mouse model for corneal surface disease and neovascularization. Invest Ophthalmol Vis Sci. 1996 Feb;37(2):397-404
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(58)

Other accession IDs

MGD-MRK-33921, MGI:106229, MGI:1917157, MGI:2139214