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Sae1
Gene Detail
 Symbol
Name
ID
Sae1
SUMO1 activating enzyme subunit 1
MGI:1929264
Synonyms 2400010M20Rik, 2610044L12Rik, AOS1, D7Ertd177e, HSPC140, SUMO-1 activating enzyme subunit 1, Uble1a
Feature Type protein coding gene
Genetic Map
Chromosome 7
8.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:16327054-16387785 bp, - strand
From NCBI annotation of GRCm38

  60732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4019  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SUMO-activating enzyme subunit 1
Gene Tree: Sae1

Human
homologs
Human Homolog SAE1, SUMO1 activating enzyme subunit 1
NCBI Gene ID 10055
neXtProt AC  NX_Q9UBE0
Human Synonyms  AOS1, HSPC140, SUA1, UBLE1A
Human Chr (Location)  19q13.32; chr19:47130782-47210636 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(65) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sae1 interacts with 96 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular protein modification process, protein sumoylation, ...
Component cytosol, intracellular membrane-bounded organelle, ...
Function ATP-dependent protein binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (26)    Images (6)
Theiler Stages: 17, 20
Assay TypeResults
RNA in situ 34
cDNA source data(242)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(243) cDNA(242) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000052833 (Evidence)
Entrez Gene56459 (Evidence)
UniGene258530
DFCITC1571875, TC1689495
DoTSDT.101132407, DT.494831, DT.91430335, DT.94406854, DT.94406874
NIA Mouse Gene IndexU028185
Consensus CDS ProjectCCDS20848.1
International Mouse Knockout Project StatusSae1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56459 NCBI Gene Model | MGI Sequence Detail 60732 C57BL/6J ±  kb
transcript NM_019748 RefSeq | MGI Sequence Detail 2017 C57BL/6 
polypeptide Q9R1T2 UniProt | EBI | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(418 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009036 Molybdenum cofactor biosynthesis, MoeB
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
InterPro IPR000011 Ubiquitin/SUMO-activating enzyme E1
Protein Ontology PR:000014431 SUMO-activating enzyme subunit 1
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:186944 Ban R, et al., Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Genes Cells. 2011 Jun;16(6):652-69
All references(43)
Other
accession IDs
MGI:1098682, MGI:1914236, MGI:1923788, MGI:2142107, MGI:2142274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory