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Mtch2 Gene Detail
Summary
  • Symbol
    Mtch2
  • Name
    mitochondrial carrier 2
  • Synonyms
    2310034D24Rik, 4930539J07Rik, HSPC032
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929260
    NCBI Gene: 56428
  • Gene Overview
    MyGene.info: MTCH2
Location & Maps
more
  • Sequence Map
    Chr2:90847155-90866810 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19656 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.41 cM, cytoband E1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MTCH2, mitochondrial carrier 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTCH2, mitochondrial carrier 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC032, MIMP, SLC25A50
  • Links
    NCBI Gene ID: 23788
    neXtProt AC: NX_Q9Y6C9

  • Chr Location
    11p11.2; chr11:47605204-47642654 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8645
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MTCH2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    38
  • Chemically induced (other)
    1
  • Gene trapped
    27
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    4 involving Mtch2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal mesoderm development, disorganized extraembryonic tissue, lack of amnion and chorion formation, decreased embryo size, and lethality at around E7.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014305 VEGA Gene Model | MGI Sequence Detail 19656 C57BL/6J ±  kb
transcript OTTMUST00000033727 VEGA | MGI Sequence Detail 2377 Not Applicable  
polypeptide OTTMUSP00000015115 VEGA | MGI Sequence Detail 312 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    84 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010713 mitochondrial carrier homolog 2
  • InterPro Domains
    IPR023395 Mitochondrial carrier domain
    IPR018108 Mitochondrial substrate/solute carrier
Molecular
Reagents
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  • All nucleic 208
    cDNA 208

    Microarray probesets 8
Other
Accession IDs
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MGI:1914196, MGI:1922482
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224442 Maryanovich M, et al., An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat Commun. 2015;6:7901

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory