Kcnip3 MGI Mouse Gene Detail - MGI:1929258 - Kv channel interacting protein 3, calsenilin

Kcnip3 Gene Detail

Symbol

Kcnip3
Name

Kv channel interacting protein 3, calsenilin
Synonyms

4933407H12Rik, Csen, DREAM, KChIP3, R74849

Feature Type

protein coding gene
IDs

MGI:1929258
NCBI Gene: 56461
Gene Overview

MyGene.info: KCNIP3

Sequence Map

Chr2:127456498-127522094 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

65597 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.02 cM
Mapping Data

2 experiments

Human Ortholog

KCNIP3, potassium voltage-gated channel interacting protein 3

Vertebrate Orthologs

10

Human Ortholog

KCNIP3, potassium voltage-gated channel interacting protein 3
Orthology source: HomoloGene, HGNC
Synonyms

CSEN, DREAM, KCHIP3
Links

HGNC:15523

NCBI Gene ID: 30818

neXtProt AC: NX_Q9Y2W7
Chr Location

2q21.1; chr2:95297324-95386077 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 8382
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: KCNIP3
Gene Tree

Kcnip3

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Phenotype Summary

15 phenotypes from 3 alleles in 3 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

8
Transgenic

5
Genomic Mutations

2 involving Kcnip3
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a null allele exhibit abnormal spatial learning, hyperactivity, hypophagia, increased sensitivity to shock, and enhanced long term potentiation.

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All GO Annotations

41
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

126
Tissues

65
cDNA Data

17
Literature Summary

5

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase kcnip3

ZFIN kcnip3b

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Kcnip3 interacts with 195 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

46
RefSeq

9
UniProt

5
CCDS

CCDS16703.1, CCDS50703.1, CCDS71139.1
UniGene

315292

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016030	VEGA Gene Model \| MGI Sequence Detail	65597	C57BL/6J	± kb
transcript	OTTMUST00000038216	VEGA \| MGI Sequence Detail	2728	Not Applicable
polypeptide	OTTMUSP00000017138	VEGA \| MGI Sequence Detail	284	Not Applicable

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SNPs within 2kb

649 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000009262 calsenilin
PDB

2JUL
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR028846 Recoverin family

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All nucleic 21

cDNA 18

Primer pair 3

Microarray probesets 3

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MGI:1921323, MGI:2138928, MGI:2139540

Summaries

All 58

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 26
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:231158 Naranjo JR, et al., Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. J Clin Invest. 2016 Feb 1;126(2):627-38

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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