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Kcnip3
Gene Detail
Symbol

Name
ID
Kcnip3
Kv channel interacting protein 3, calsenilin
MGI:1929258
Synonyms
4933407H12Rik, Csen, DREAM, KChIP3, R74849
Feature Type
protein coding gene
Genetic Map
Chromosome 2
62.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:127456498-127522094 bp, - strand
From VEGA annotation of GRCm38

  65597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: KCNIP3
Gene Tree: Kcnip3

Human
homologs
KCNIP3, Kv channel interacting protein 3, calsenilin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 30818
neXtProt AC: NX_Q9Y2W7

Human Synonyms: CSEN, DREAM, KCHIP3

Human Chr (Location): 2q21.1; chr2:95297324-95386077 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit abnormal spatial learning, hyperactivity, hypophagia, increased sensitivity to shock, and enhanced long term potentiation.
 
Interactions
Kcnip3 interacts with 195 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process apoptotic process, behavioral response to pain, ...
Component axon, axon terminus, ...
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (126)    Tissues (65)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 76
RT-PCR 50
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN kcnip3b    NEW 
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016030 (Evidence)
Ensembl Gene Model ENSMUSG00000079056 (Evidence)
Entrez Gene 56461 (Evidence)
UniGene 315292
DFCI TC1579953, TC1592223
DoTS DT.110662808, DT.482355
NIA Mouse Gene Index U023321
PDB 2JUL
Consensus CDS Project CCDS16703.1, CCDS50703.1, CCDS71139.1
International Mouse Phenotyping Consortium Status Kcnip3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016030 VEGA Gene Model | MGI Sequence Detail 65597 C57BL/6J ±  kb
transcript OTTMUST00000038216 VEGA | MGI Sequence Detail 2728 Not Applicable 
polypeptide OTTMUSP00000017138 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(9) UniProt(5)
Polymorphisms
SNPs within 2kb(654 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000034282 calsenilin isoform 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209800 Tiruppathi C, et al., The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nat Immunol. 2014 Mar;15(3):239-47
All references(55)
Other
accession IDs
MGI:1921323, MGI:2138928, MGI:2139540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory