Kcnip3 MGI Mouse Gene Detail - MGI:1929258 - Kv channel interacting protein 3, calsenilin

Symbol

Kcnip3
Name

Kv channel interacting protein 3, calsenilin
Synonyms

4933407H12Rik, Csen, DREAM, KChIP3, R74849

Feature Type

protein coding gene
IDs

MGI:1929258
NCBI Gene: 56461
Gene Overview

MyGene.info: KCNIP3
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:127456498-127522094 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.02 cM
Mapping Data

2 experiments

SNPs within 2kb

649 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929258	protein coding gene	Chr2:127456498-127522094 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026461	protein coding gene	Chr2:130749537-130814878 (-)
A/J	MGP_AJ_G0026425	protein coding gene	Chr2:125444447-125512215 (-)
AKR/J	MGP_AKRJ_G0026400	protein coding gene	Chr2:129027609-129093222 (-)
BALB/cJ	MGP_BALBcJ_G0026437	protein coding gene	Chr2:125711678-125778708 (-)
C3H/HeJ	MGP_C3HHeJ_G0026180	protein coding gene	Chr2:129541461-129609987 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026882	protein coding gene	Chr2:134850294-134918819 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024259	protein coding gene	Chr2:120286416-120354803 (-)
CAST/EiJ	MGP_CASTEiJ_G0025641	protein coding gene	Chr2:129743933-129811034 (-)
CBA/J	MGP_CBAJ_G0026160	protein coding gene	Chr2:139837088-139914251 (-)
DBA/2J	MGP_DBA2J_G0026294	protein coding gene	Chr2:124853334-124918414 (-)
FVB/NJ	MGP_FVBNJ_G0026258	protein coding gene	Chr2:123504681-123571941 (-)
LP/J	MGP_LPJ_G0026399	protein coding gene	Chr2:130976693-131057309 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026278	protein coding gene	Chr2:143858869-143929128 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026937	protein coding gene	Chr2:129051058-129117570 (-)
PWK/PhJ	MGP_PWKPhJ_G0025377	protein coding gene	Chr2:124401903-124467960 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025179	protein coding gene	Chr2:128133574-128199846 (-)
WSB/EiJ	MGP_WSBEiJ_G0025715	protein coding gene	Chr2:129946082-130016628 (-)

Human Ortholog

KCNIP3, potassium voltage-gated channel interacting protein 3

Vertebrate Orthologs

10

Human Ortholog

KCNIP3, potassium voltage-gated channel interacting protein 3
Orthology source: HomoloGene, HGNC
Synonyms

CSEN, DREAM, KCHIP3
Links

HGNC:15523

NCBI Gene ID: 30818

neXtProt AC: NX_Q9Y2W7

UniProt: Q9Y2W7
Chr Location

2q11.1; chr2:95297324-95386077 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8382
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KCNIP3
Gene Tree

Kcnip3

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Phenotype Summary

15 phenotypes from 3 alleles in 3 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

9
Transgenic

6
Genomic Mutations

2 involving Kcnip3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a null allele exhibit abnormal spatial learning, hyperactivity, hypophagia, increased sensitivity to shock, and enhanced long term potentiation.

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All GO Annotations

45
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

126
Tissues

65
cDNA Data

18
Literature Summary

8

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnip3

ZFIN kcnip3b

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Kcnip3 interacts with 195 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

56
RefSeq

9
UniProt

5
CCDS

CCDS16703.1, CCDS50703.1, CCDS71139.1
UniGene

315292

Ensembl

ENSMUSG00000079056 (Evidence)
NCBI Gene

56461

			Length	Strain/Species	Flank
genomic	56461	NCBI Gene Model \| MGI Sequence Detail	65597	C57BL/6J	± kb
transcript	NR_110989	RefSeq \| MGI Sequence Detail	2935	C57BL/6
polypeptide	Q9QXT8	UniProt \| EBI \| MGI Sequence Detail	256	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009262 calsenilin

(term hierarchy)
PDB

2JUL
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 22

cDNA 19

Primer pair 3

Microarray probesets 3

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MGI:1921323, MGI:2138928, MGI:2139540

Summaries

All 74

Developmental Gene Expression 8

Gene Ontology 10

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:242108 Benedet T, et al., Transcriptional repressor DREAM regulates trigeminal noxious perception. J Neurochem. 2017 May;141(4):544-552

TSS for Kcnip3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26127	Chr2:127521358-127521375 (-)	727 bp
Tssr26126	Chr2:127521331-127521357 (-)	750 bp
Tssr26125	Chr2:127521306-127521322 (-)	780 bp
Tssr26124	Chr2:127521273-127521282 (-)	816 bp
Tssr26121	Chr2:127482541-127482577 (-)	39,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13