About   Help   FAQ
Kcnip3
Gene Detail
 Symbol
Name
ID
Kcnip3
Kv channel interacting protein 3, calsenilin
MGI:1929258
Synonyms 4933407H12Rik, Csen, DREAM, KChIP3, R74849
Feature Type protein coding gene
Genetic Map
Chromosome 2
62.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:127456498-127522094 bp, - strand
From VEGA annotation of GRCm38

  65597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Kcnip3

Human
homologs
Human Homolog KCNIP3, Kv channel interacting protein 3, calsenilin
NCBI Gene ID 30818
neXtProt AC  NX_Q9Y2W7
Human Synonyms  CSEN, DREAM, KCHIP3
Human Chr (Location)  2q21.1; chr2:95297324-95386077 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit abnormal spatial learning, hyperactivity, hypophagia, increased sensitivity to shock, and enhanced long term potentiation.
 
Interactions
Kcnip3 interacts with 196 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process apoptotic process, behavioral response to pain, ...
Component axon, axon terminus, ...
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (126)    Tissues (65)   
Theiler Stages: 21, 23, 27, 28
Assay TypeResults
RNA in situ 76
RT-PCR 50
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016030 (Evidence)
Ensembl Gene ModelENSMUSG00000079056 (Evidence)
Entrez Gene56461 (Evidence)
UniGene315292
DFCITC1579953, TC1592223
DoTSDT.110662808, DT.482355
NIA Mouse Gene IndexU023321
PDB2JUL
Consensus CDS ProjectCCDS16703.1, CCDS50703.1, CCDS71139.1
International Mouse Knockout Project StatusKcnip3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016030 VEGA Gene Model | MGI Sequence Detail 65597 C57BL/6J ±  kb
transcript OTTMUST00000038216 VEGA | MGI Sequence Detail 2728 Not Applicable 
polypeptide OTTMUSP00000017138 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(15) UniProt(5)
Polymorphisms SNPs within 2kb(654 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000034282 calsenilin isoform 4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209800 Tiruppathi C, et al., The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nat Immunol. 2014 Mar;15(3):239-47
All references(56)
Other
accession IDs
MGI:1921323, MGI:2138928, MGI:2139540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory