Kcnip3
Gene Detail

Symbol

Name
ID

Kcnip3
Kv channel interacting protein 3, calsenilin
MGI:1929258

Synonyms

4933407H12Rik, Csen, DREAM, KChIP3, R74849

Feature Type

protein coding gene

Genetic Map

Chromosome 2
62.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:127456498-127522094 bp, - strand From VEGA annotation of GRCm38   65597 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:8382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Kcnip3

Human
homologs

Human Homolog		KCNIP3, Kv channel interacting protein 3, calsenilin
NCBI Gene ID		30818
neXtProt AC		NX_Q9Y2W7
Human Synonyms		CSEN, DREAM, KCHIP3
Human Chr (Location)		2q21.1; chr2:95297324-95386077 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit abnormal spatial learning, hyperactivity, hypophagia, increased sensitivity to shock, and enhanced long term potentiation.

 

Interactions

Kcnip3 interacts with 196 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (42 annotations)

Process	apoptotic process, behavioral response to pain, ...
Component	axon, axon terminus, ...
Function	calcium-dependent protein binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (126)    Tissues (65)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	76
RT-PCR	50

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000016030 (Evidence)
Ensembl Gene Model	ENSMUSG00000079056 (Evidence)
Entrez Gene	56461 (Evidence)
UniGene	315292
DFCI	TC1579953, TC1592223
DoTS	DT.482355, DT.110662808
NIA Mouse Gene Index	U023321
PDB	2JUL
Consensus CDS Project	CCDS16703.1, CCDS50703.1, CCDS71139.1
International Mouse Knockout Project Status	Kcnip3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016030	VEGA Gene Model | MGI Sequence Detail	65597	C57BL/6J
transcript	OTTMUST00000038216	VEGA | MGI Sequence Detail	2728	Not Applicable
polypeptide	OTTMUSP00000017138	VEGA | MGI Sequence Detail	284	Not Applicable

All sequences(64) RefSeq(15) UniProt(9)

Polymorphisms

SNPs within 2kb(654 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
Protein Ontology	PR:000034282	calsenilin isoform 4

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209800 Tiruppathi C, et al., The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nat Immunol. 2014 Mar;15(3):239-47
All references(56)

Other
accession IDs

MGI:1921323, MGI:2138928, MGI:2139540