Pus1
Gene Detail

Symbol Name ID

Pus1 pseudouridine synthase 1 MGI:1929237

Synonyms

A730013B20Rik, MPUS1, mPus1p

Feature Type

protein coding gene

Genetic Map

Chromosome 5

53.70 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:110773667-110780659 bp, - strand From VEGA annotation of GRCm38   6993 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tRNA-pseudouridine synthase A, eukaryotic type
Gene Tree: Pus1

Human homologs

Human Homolog		PUS1, pseudouridylate synthase 1
NCBI Gene ID		80324
neXtProt AC		NX_Q9Y606
Human Synonyms		MLASA1
Human Chr (Location)		12q24.33; chr12:132413745-132428406 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PUS1

Alleles and phenotypes

All alleles(14) : Targeted(2) Gene trapped(12)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	metabolic process, positive regulation of transcription from RNA polymerase II promoter, ...
Component	mitochondrion, nucleolus, ...
Function	DNA binding, isomerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(12)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023691 (Evidence)
Ensembl Gene Model	ENSMUSG00000029507 (Evidence)
Entrez Gene	56361 (Evidence)
NIA Mouse Gene Index	U026566
EC	5.4.99.-, 5.4.99.12
Consensus CDS Project	CCDS19530.1, CCDS19531.1, CCDS39212.1
International Mouse Knockout Project Status	Pus1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023691	VEGA Gene Model | MGI Sequence Detail	6993	C57BL/6J
transcript	OTTMUST00000057852	VEGA | MGI Sequence Detail	1868	Not Applicable
polypeptide	OTTMUSP00000027966	VEGA | MGI Sequence Detail	441	Not Applicable

All sequences(59) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020103	Pseudouridine synthase, catalytic domain
InterPro	IPR001406	Pseudouridine synthase I, TruA
InterPro	IPR020097	Pseudouridine synthase I, TruA, alpha/beta domain
InterPro	IPR020095	Pseudouridine synthase I, TruA, C-terminal
InterPro	IPR020094	Pseudouridine synthase I, TruA, N-terminal
Protein Ontology	PR:000013497	tRNA pseudouridine synthase A

References

(Earliest) J:66589 Chen J, et al., Cloning and characterization of a mammalian pseudouridine synthase. RNA. 1999 Mar;5(3):409-19
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Other accession IDs

MGI:2443494