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Pus1
Gene Detail
Symbol

Name
ID
Pus1
pseudouridine synthase 1
MGI:1929237
Synonyms
A730013B20Rik, MPUS1, mPus1p
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.70 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:110773667-110780659 bp, - strand
From VEGA annotation of GRCm38

  6993 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tRNA-pseudouridine synthase A, eukaryotic type
Gene Tree: Pus1

Human
homologs
Human Homolog PUS1, pseudouridylate synthase 1
NCBI Gene ID 80324
neXtProt AC  NX_Q9Y606
Human Synonyms  MLASA1
Human Chr (Location)  12q24.33; chr12:131929200-131943861 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PUS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pus1 interacts with 61 markers (Mir17, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023691 (Evidence)
Ensembl Gene ModelENSMUSG00000029507 (Evidence)
Entrez Gene56361 (Evidence)
UniGene23528
NIA Mouse Gene IndexU026566
EC5.4.99.-, 5.4.99.12
Consensus CDS ProjectCCDS19530.1, CCDS19531.1, CCDS39212.1
International Mouse Knockout Project StatusPus1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023691 VEGA Gene Model | MGI Sequence Detail 6993 C57BL/6J ±  kb
transcript OTTMUST00000057852 VEGA | MGI Sequence Detail 1868 Not Applicable 
polypeptide OTTMUSP00000027966 VEGA | MGI Sequence Detail 441 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020103 Pseudouridine synthase, catalytic domain
InterPro IPR001406 Pseudouridine synthase I, TruA
InterPro IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain
InterPro IPR020095 Pseudouridine synthase I, TruA, C-terminal
InterPro IPR020094 Pseudouridine synthase I, TruA, N-terminal
Protein Ontology PR:000013497 tRNA pseudouridine synthase A, mitochondrial
References
(Earliest) J:66589 Chen J, et al., Cloning and characterization of a mammalian pseudouridine synthase. RNA. 1999 Mar;5(3):409-19
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGI:2443494

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory