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Vps41
Gene Detail
 Symbol
Name
ID
Vps41
vacuolar protein sorting 41 (yeast)
MGI:1929215
Synonyms mVam2, Vam2
Feature Type protein coding gene
Genetic Map
Chromosome 13
6.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:18717292-18866809 bp, + strand
From Ensembl annotation of GRCm38

  149518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: vacuolar protein sorting-associated protein Vps41
Gene Tree: Vps41

Human
homologs
Human Homolog VPS41, vacuolar protein sorting 41 homolog (S. cerevisiae)
NCBI Gene ID 27072
neXtProt AC  NX_P49754
Human Synonyms  HVPS41, hVps41p, HVSP41
Human Chr (Location)  7p14-p13; chr7:38723943-38909200 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a knock-out allele die by E9 exhibiting morphological and functional alteration of late endocytic compartments, and abnormal triploblastic development.
 
Interactions
Vps41 interacts with 143 markers (Mir1b, Mir7-1, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process Golgi vesicle transport, intracellular protein transport, ...
Component cytosol, early endosome, ...
Function metal ion binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(168)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(168) cDNA(168)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000041236 (Evidence)
Entrez Gene218035 (Evidence)
UniGene27389
DFCITC1572682, TC1703912
DoTSDT.101329799, DT.533785
NIA Mouse Gene IndexU014579
Consensus CDS ProjectCCDS26257.1
International Mouse Knockout Project StatusVps41
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041236 Ensembl Gene Model | MGI Sequence Detail 149518 C57BL/6J ±  kb
transcript ENSMUST00000072961 Ensembl | MGI Sequence Detail 3195 Not Applicable 
polypeptide ENSMUSP00000072729 Ensembl | MGI Sequence Detail 853 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR016902 Vacuolar protein sorting-associated protein 41
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000017340 vacuolar protein sorting-associated protein 41
References (Earliest) J:61187 Gwynn B, et al., Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism. Blood. 2000 Dec 15;96(13):4227-35
(Latest) J:184591 Aoyama M, et al., Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
All references(38)
Other
accession IDs
MGI:2145205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory