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Vps41 Gene Detail
Summary
  • Symbol
    Vps41
  • Name
    VPS41 HOPS complex subunit
  • Synonyms
    mVam2, Vam2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929215
    NCBI Gene: 218035
Location & Maps
more
  • Sequence Map
    Chr13:18717292-18866809 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      149518 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VPS41, VPS41, HOPS complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS41, VPS41, HOPS complex subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HVPS41, hVps41p, HVSP41
  • Links
    NCBI Gene ID: 27072
    neXtProt AC: NX_P49754

  • Chr Location
    7p14-p13; chr7:38723943-38909200 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    14
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Vps41
  • Incidental Mutations
Embryos homozygous for a knock-out allele die by E9 exhibiting morphological and functional alteration of late endocytic compartments, and abnormal triploblastic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041236 Ensembl Gene Model | MGI Sequence Detail 149518 C57BL/6J ±  kb
transcript ENSMUST00000072961 Ensembl | MGI Sequence Detail 3195 Not Applicable  
polypeptide ENSMUSP00000072729 Ensembl | MGI Sequence Detail 853 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1241 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017340 vacuolar protein sorting-associated protein 41
  • InterPro Domains
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain
    IPR016902 Vacuolar protein sorting-associated protein 41
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
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  • All nucleic 169
    cDNA 169

    Microarray probesets 4
Other
Accession IDs
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MGI:2145205
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:61187 Gwynn B, et al., Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism. Blood. 2000 Dec 15;96(13):4227-35
  • Latest
    J:184591 Aoyama M, et al., Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory