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Vps41
Gene Detail
Symbol

Name
ID
Vps41
vacuolar protein sorting 41 (yeast)
MGI:1929215
Synonyms
mVam2, Vam2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
6.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:18717292-18866809 bp, + strand
From Ensembl annotation of GRCm38

  149518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VPS41
Protein SuperFamily: vacuolar protein sorting-associated protein Vps41
Gene Tree: Vps41

Human
homologs
VPS41, vacuolar protein sorting 41 homolog (S. cerevisiae)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27072
neXtProt AC: NX_P49754

Human Synonyms: HVPS41, hVps41p, HVSP41

Human Chr (Location): 7p14-p13; chr7:38723943-38909200 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Radiation induced(1) Targeted(2)
Genomic Mutations involving Vps41 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Embryos homozygous for a knock-out allele die by E9 exhibiting morphological and functional alteration of late endocytic compartments, and abnormal triploblastic development.
 
Interactions
Vps41 interacts with 143 markers (Mir1b, Mir7-1, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process Golgi vesicle transport, intracellular protein transport, ...
Component CORVET complex, cytosol, ...
Function GTPase binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(169)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vps41    NEW 
Molecular
reagents
All nucleic(169) cDNA(169)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000041236 (Evidence)
Entrez Gene 218035 (Evidence)
UniGene 27389
DFCI TC1572682, TC1703912
DoTS DT.101329799, DT.533785
NIA Mouse Gene Index U014579
Consensus CDS Project CCDS26257.1
International Mouse Phenotyping Consortium Status Vps41
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041236 Ensembl Gene Model | MGI Sequence Detail 149518 C57BL/6J ±  kb
transcript ENSMUST00000072961 Ensembl | MGI Sequence Detail 3195 Not Applicable 
polypeptide ENSMUSP00000072729 Ensembl | MGI Sequence Detail 853 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(1267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR016902 Vacuolar protein sorting-associated protein 41
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000017340 vacuolar protein sorting-associated protein 41
References
(Earliest) J:61187 Gwynn B, et al., Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism. Blood. 2000 Dec 15;96(13):4227-35
(Latest) J:184591 Aoyama M, et al., Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
All references(37)
Other
accession IDs
MGI:2145205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory