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Vps41 Gene Detail
Summary
  • Symbol
    Vps41
  • Name
    VPS41 HOPS complex subunit
  • Synonyms
    mVam2, Vam2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929215
    NCBI Gene: 218035
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:18717292-18866811 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1241 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929215
protein coding gene Chr13:18717286-18866811 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020256
protein coding gene Chr13:15824461-15982410 (+)
A/J MGP_AJ_G0020213
protein coding gene Chr13:15622297-15773545 (+)
AKR/J MGP_AKRJ_G0020187
protein coding gene Chr13:15805952-15968121 (+)
BALB/cJ MGP_BALBcJ_G0020199
protein coding gene Chr13:15579319-15732055 (+)
C3H/HeJ MGP_C3HHeJ_G0020002
protein coding gene Chr13:15926804-16092808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020643
protein coding gene Chr13:16509230-16675334 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018250
protein coding gene Chr13:14062940-14222376 (+)
CAST/EiJ MGP_CASTEiJ_G0019537
protein coding gene Chr13:15669534-15828938 (+)
CBA/J MGP_CBAJ_G0019966
protein coding gene Chr13:17078652-17238825 (+)
DBA/2J MGP_DBA2J_G0020085
protein coding gene Chr13:15198456-15348972 (+)
FVB/NJ MGP_FVBNJ_G0020067
protein coding gene Chr13:14893104-15042050 (+)
LP/J MGP_LPJ_G0020156
protein coding gene Chr13:16113286-16280510 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020105
protein coding gene Chr13:17435065-17599045 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020672
protein coding gene Chr13:15615195-15768992 (+)
PWK/PhJ MGP_PWKPhJ_G0019300
protein coding gene Chr13:15251035-15407573 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019106
protein coding gene Chr13:14748011-14909591 (+)
WSB/EiJ MGP_WSBEiJ_G0019596
protein coding gene Chr13:15644044-15805998 (+)



Homology
more
  • Human Ortholog
    VPS41, VPS41 subunit of HOPS complex
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS41, VPS41 subunit of HOPS complex
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HVPS41, hVps41p, HVSP41
  • Links
    NCBI Gene ID: 27072
    neXtProt AC: NX_P49754
    UniProt: P49754

  • Chr Location
    7p14.1; chr7:38722974-38909200 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele die by E9 exhibiting morphological and functional alteration of late endocytic compartments, and abnormal triploblastic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 218035 NCBI Gene Model | MGI Sequence Detail 149520 C57BL/6J ±  kb
transcript NM_172120 RefSeq | MGI Sequence Detail 3212 C57BL/6  
polypeptide Q5KU39 UniProt | EBI | MGI Sequence Detail 853 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017340 vacuolar protein sorting-associated protein 41
  • InterPro Domains
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR016902 Vacuolar protein sorting-associated protein 41
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
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  • All nucleic 170
    cDNA 170

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145205
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:61187 Gwynn B, et al., Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism. Blood. 2000 Dec 15;96(13):4227-35
  • Latest
    J:184591 Aoyama M, et al., Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory