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Vps41 Gene Detail
Summary
  • Symbol
    Vps41
  • Name
    VPS41 HOPS complex subunit
  • Synonyms
    mVam2, Vam2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929215
    NCBI Gene: 218035
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:18717292-18866811 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      149520 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.75 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    VPS41, VPS41, HOPS complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS41, VPS41, HOPS complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HVPS41, hVps41p, HVSP41
  • Links
    NCBI Gene ID: 27072
    neXtProt AC: NX_P49754
    UniProt: P49754

  • Chr Location
    7p14.1; chr7:38722974-38909200 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele die by E9 exhibiting morphological and functional alteration of late endocytic compartments, and abnormal triploblastic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 218035 NCBI Gene Model | MGI Sequence Detail 149520 C57BL/6J ±  kb
transcript NM_172120 RefSeq | MGI Sequence Detail 3212 C57BL/6  
polypeptide Q5KU39 UniProt | EBI | MGI Sequence Detail 853 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1241 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017340 vacuolar protein sorting-associated protein 41
  • InterPro Domains
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR016902 Vacuolar protein sorting-associated protein 41
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
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  • All nucleic 169
    cDNA 169

    Microarray probesets 4
Other
Accession IDs
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MGI:2145205
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:16316 Tease C, et al., Cytogenetic detection of four new, viable deletions in the progeny of X-irradiated females. Mouse Genome. 1993;91(4):855
  • Latest
    J:184591 Aoyama M, et al., Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory