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Ap3m2
Gene Detail
Symbol

Name
ID
Ap3m2
adaptor-related protein complex 3, mu 2 subunit
MGI:1929214
Synonyms
5830445E16Rik, AP-3B
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:22787354-22805654 bp, - strand
From NCBI annotation of GRCm38

  18301 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AP3M2
Protein SuperFamily: adaptor protein complex, mu subunit
Gene Tree: Ap3m2

Human
homologs
AP3M2, adaptor-related protein complex 3, mu 2 subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10947
neXtProt AC: NX_P53677

Human Synonyms: AP47B, CLA20, P47B

Human Chr (Location): 8p11.2; chr8:42152946-42171183 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(8) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice suffer from spontaneous recurrent epileptic seizures, are more susceptible to drug-induced seizures and show impaired GABA release, fewer synaptic vesicles, enhanced long-term potentiation, and abnormal propagation of neuronal excitability via the temporoammonic pathway.
 
Interactions
Ap3m2 interacts with 229 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process anterograde axon cargo transport, anterograde synaptic vesicle transport, ...
Component cell, clathrin adaptor complex, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (163)    Tissues (18)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 163
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap3m2    NEW 
Molecular
reagents
All nucleic(37) cDNA(37)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000031539 (Evidence)
Entrez Gene 64933 (Evidence)
UniGene 390023
DFCI TC1676421, TC1577074
DoTS DT.99856338, DT.99856337, DT.528978
NIA Mouse Gene Index U029641
Consensus CDS Project CCDS22184.1
International Mouse Phenotyping Consortium Status Ap3m2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 64933 NCBI Gene Model | MGI Sequence Detail 18301 C57BL/6J ±  kb
transcript NM_001122820 RefSeq | MGI Sequence Detail 3467 C57BL/6 
polypeptide Q8R2R9 UniProt | EBI | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR001392 Clathrin adaptor, mu subunit
InterPro IPR018240 Clathrin adaptor, mu subunit, conserved site
InterPro IPR008968 Clathrin adaptor, mu subunit, C-terminal
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004108 AP-3 complex subunit mu-2
Graphical View of Protein Domain Structure
References
(Earliest) J:61187 Gwynn B, et al., Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism. Blood. 2000 Dec 15;96(13):4227-35
(Latest) J:216875 Bubier JA, et al., Identification of a QTL in Mus musculus for alcohol preference, withdrawal, and Ap3m2 expression using integrative functional genomics and precision genetics. Genetics. 2014 Aug;197(4):1377-93
All references(32)
Other
accession IDs
MGI:1923308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory