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Izumo1r Gene Detail
Summary
  • Symbol
    Izumo1r
  • Name
    IZUMO1 receptor, JUNO
  • Synonyms
    0910001L11Rik, Folbp3, Folr4, Juno
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929185
    NCBI Gene: 64931
  • Gene Overview
    MyGene.info: IZUMO1R
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14885814-14903949 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 4.42 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929185
protein coding gene Chr9:14885814-14903951 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034358
protein coding gene Chr9:11849814-11867954 (-)
A/J MGP_AJ_G0034336
protein coding gene Chr9:11793237-11811372 (-)
AKR/J MGP_AKRJ_G0034264
protein coding gene Chr9:11801698-11819833 (-)
BALB/cJ MGP_BALBcJ_G0034330
protein coding gene Chr9:11562771-11580913 (-)
C3H/HeJ MGP_C3HHeJ_G0034041
protein coding gene Chr9:12110030-12128165 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034852
protein coding gene Chr9:12234497-12252632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031790
protein coding gene Chr9:11090702-11108378 (-)
CAST/EiJ MGP_CASTEiJ_G0033368
protein coding gene Chr9:11956671-11974767 (-)
CBA/J MGP_CBAJ_G0034014
protein coding gene Chr9:12800027-12818163 (-)
DBA/2J MGP_DBA2J_G0034171
protein coding gene Chr9:11667870-11686008 (-)
FVB/NJ MGP_FVBNJ_G0034116
protein coding gene Chr9:11262497-11280632 (-)
LP/J MGP_LPJ_G0034257
protein coding gene Chr9:11949711-11967849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034160
protein coding gene Chr9:13839403-13857534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034871
protein coding gene Chr9:11821971-11840102 (-)
PWK/PhJ MGP_PWKPhJ_G0033074
protein coding gene Chr9:11740428-11758544 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032910
protein coding gene Chr9:11913418-11934821 (-)
WSB/EiJ MGP_WSBEiJ_G0033484
protein coding gene Chr9:11673704-11693603 (-)



Homology
more
  • Human Ortholog
    IZUMO1R, IZUMO1 receptor, JUNO
  • Vertebrate Orthologs
    5
  • Human Ortholog
    IZUMO1R, IZUMO1 receptor, JUNO
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Folbp3, FOLR4, JUNO
  • Links
    NCBI Gene ID: 390243
    neXtProt AC: NX_A6ND01
    UniProt: A6ND01

  • Chr Location
    11q21; chr11:94305637-94307692 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 6 alleles in 6 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes female infertility. Homozygous null eggs do not fuse with normal sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031933 Ensembl Gene Model | MGI Sequence Detail 18136 C57BL/6J ±  kb
    transcript ENSMUST00000034409 Ensembl | MGI Sequence Detail 1291 Not Applicable  
    polypeptide ENSMUSP00000034409 Ensembl | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915662, MGI:2143432
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:240828 Kato K, et al., Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. Nat Commun. 2016 Jul 15;7:12198

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory