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Sap30 Gene Detail
Summary
  • Symbol
    Sap30
  • Name
    Sin3A associated protein 30
  • Synonyms
    30kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929129
    NCBI Gene: 60406
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:57935740-57940874 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 29.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929129
 protein coding gene Chr8:57935740-57940894 (-)
129S1/SvImJ ENSMUSG00200006984
 protein coding gene Chr8:52721575-52726731 (-)
A/J ENSMUSG00195011894
 protein coding gene Chr8:53123155-53128311 (-)
AKR/J ENSMUSG00220005476
 protein coding gene Chr8:52940879-52946034 (-)
BALB/cJ ENSMUSG00180014064
 protein coding gene Chr8:52771065-52776217 (-)
C3H/HeJ ENSMUSG00175007348
 protein coding gene Chr8:52948283-52953439 (-)
C57BL/6NJ ENSMUSG00215007346
 protein coding gene Chr8:52741046-52746200 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031066
 protein coding gene Chr8:50348060-50353455 (-)
CAST/EiJ ENSTCUG00005006637
 protein coding gene Chr8:52691831-52696986 (-)
CBA/J ENSMUSG00210009060
 protein coding gene Chr8:52797291-52802446 (-)
DBA/2J ENSMUSG00185007926
 protein coding gene Chr8:58930329-58935484 (-)
FVB/NJ ENSMUSG00205011053
 protein coding gene Chr8:52185301-52190456 (-)
JF1/MsJ ENSUMUG00000008458
 protein coding gene Chr8:61266435-61271605 (-)
LP/J ENSMUSG00230005648
 protein coding gene Chr8:62589364-62594518 (-)
NOD/ShiLtJ ENSMUSG00190009410
 protein coding gene Chr8:52718513-52723668 (-)
NZO/HlLtJ ENSMUSG00225030210
 protein coding gene Chr8:66020581-66025736 (-)
PWK/PhJ ENSLUMG00010012377
 protein coding gene Chr8:52637189-52642367 (-)
SPRET/EiJ ENSMSPG00010014017
 protein coding gene Chr8:53713923-53719103 (-)
WSB/EiJ ENSIUOG00005016221
 protein coding gene Chr8:53643310-53648475 (-)



Homology
more
  • Human Ortholog
    SAP30, Sin3A associated protein 30
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAP30, Sin3A associated protein 30
  • Links
    NCBI Gene ID: 8819
    UniProt: O75446

  • Chr Location
    4q34.1; chr4:173369969-173377532 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    28
  • cDNA Data
    73
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60406 NCBI Gene Model | MGI Sequence Detail 5135 C57BL/6J ±  kb
    transcript NM_021788 RefSeq | MGI Sequence Detail 1159 C57BL/6  
    polypeptide O88574 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014448 histone deacetylase complex subunit SAP30
      (term hierarchy)
    • PDB
      2LD7
    • InterPro Domains
      IPR024145 Histone deacetylase complex subunit SAP30/SAP30-like
      IPR025718 Histone deacetylase complex subunit SAP30, Sin3 binding domain
      IPR025717 Histone deacetylase complex subunit SAP30 zinc-finger
      IPR038291 SAP30, C-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 1
      cDNA 73
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:66985 Laherty CD, et al., SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998 Jul;2(1):33-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory