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Stam2 Gene Detail
Summary
  • Symbol
    Stam2
  • Name
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
  • Synonyms
    1200004O12Rik, 5730456G07Rik, Hbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929100
    NCBI Gene: 56324
  • Gene Overview
    MyGene.info: STAM2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:52692206-52742149 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 30.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929100
protein coding gene Chr2:52691664-52742281 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025736
protein coding gene Chr2:52052452-52104716 (-)
A/J MGP_AJ_G0025712
protein coding gene Chr2:50032395-50079476 (-)
AKR/J MGP_AKRJ_G0025682
protein coding gene Chr2:51469130-51517020 (-)
BALB/cJ MGP_BALBcJ_G0025707
protein coding gene Chr2:50135057-50185402 (-)
C3H/HeJ MGP_C3HHeJ_G0025468
protein coding gene Chr2:51476204-51528953 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026153
protein coding gene Chr2:53581471-53631544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023559
protein coding gene Chr2:48005407-48051745 (-)
CAST/EiJ MGP_CASTEiJ_G0024933
protein coding gene Chr2:51589759-51637144 (-)
CBA/J MGP_CBAJ_G0025448
protein coding gene Chr2:55613637-55667760 (-)
DBA/2J MGP_DBA2J_G0025579
protein coding gene Chr2:49679323-49729112 (-)
FVB/NJ MGP_FVBNJ_G0025541
protein coding gene Chr2:49367400-49416421 (-)
LP/J MGP_LPJ_G0025667
protein coding gene Chr2:51936016-51986440 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025572
protein coding gene Chr2:56617677-56670629 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026211
protein coding gene Chr2:51402250-51453048 (-)
PWK/PhJ MGP_PWKPhJ_G0024674
protein coding gene Chr2:49566242-49614060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024480
protein coding gene Chr2:51606449-51654086 (-)
WSB/EiJ MGP_WSBEiJ_G0025000
protein coding gene Chr2:51679577-51726836 (-)



Homology
more
  • Human Ortholog
    STAM2, signal transducing adaptor molecule 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STAM2, signal transducing adaptor molecule 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Hbp, STAM2A, STAM2B
  • Links
    NCBI Gene ID: 10254
    neXtProt AC: NX_O75886
    UniProt: O75886

  • Chr Location
    2q23.3; chr2:152116801-152175992 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68490
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STAM2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal lymphocyte responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56324 NCBI Gene Model | MGI Sequence Detail 49944 C57BL/6J ±  kb
transcript NM_019667 RefSeq | MGI Sequence Detail 4124 C57BL/6  
polypeptide O88811 UniProt | EBI | MGI Sequence Detail 523 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    cDNA 80
    Other 1

    Microarray probesets 12
Other
Accession IDs
less
MGI:1917833, MGI:1918967, MGI:2139437
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:180803 Gajovic S, et al., Genes expressed after retinoic acid-mediated differentiation of embryoid bodies are likely to be expressed during embryo development. Exp Cell Res. 1998 Jul 10;242(1):138-43
  • Latest
    J:235839 Zagore LL, et al., RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development. Mol Cell Biol. 2015 Dec;35(23):4030-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory