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Uso1 Gene Detail
Summary
  • Symbol
    Uso1
  • Name
    USO1 vesicle docking factor
  • Synonyms
    TAP, transcytosis associated protein p115, Vdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929095
    NCBI Gene: 56041
  • Gene Overview
    MyGene.info: USO1
Location & Maps
more
  • Sequence Map
    Chr5:92137938-92202798 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64861 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 46.05 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    USO1, USO1 vesicle transport factor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    USO1, USO1 vesicle transport factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P115, TAP, VDP
  • Links
    NCBI Gene ID: 8615
    neXtProt AC: NX_O60763

  • Chr Location
    4q21.1; chr4:75724522-75814289 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2754
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: USO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Spontaneous
    1
  • Genomic Mutations
    3 involving Uso1
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit embryonic lethality between E3.5 and E8.5 with disruption of Golgi apparatus in blastocyst cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055587 VEGA Gene Model | MGI Sequence Detail 64861 C57BL/6J ±  kb
transcript OTTMUST00000137571 VEGA | MGI Sequence Detail 3898 Not Applicable  
polypeptide OTTMUSP00000072431 VEGA | MGI Sequence Detail 959 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    206 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017144 general vesicular transport factor p115
  • InterPro Domains
    IPR000225 Armadillo
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR006955 Uso1/p115-like vesicle tethering protein, C-terminal
    IPR024095 Vesicle tethering protein p115-like
    IPR006953 Vesicle tethering protein Uso1/P115-like , head domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:228212 Cinque L, et al., FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory