Lgals12
Gene Detail

Symbol Name ID

Lgals12 lectin, galactose binding, soluble 12 MGI:1929094

Synonyms

galectin-12, galectin-related inhibitor of proliferation, GRIP1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:7596660-7607193 bp, - strand From VEGA annotation of GRCm38   10534 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10462  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: galectin
Gene Tree: Lgals12

Human homologs

Human Homolog		LGALS12, lectin, galactoside-binding, soluble, 12
NCBI Gene ID		85329
neXtProt AC		NX_Q96DT0
Human Synonyms		GAL12, GRIP1
Human Chr (Location)		11q13; chr11:63273524-63284246 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	apoptotic process, intrinsic apoptotic signaling pathway
Component	mitochondrion, nucleus
Function	carbohydrate binding, lactose binding

External Resources: FuncBase

Expression

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(16)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034770 (Evidence)
Ensembl Gene Model	ENSMUSG00000024972 (Evidence)
Entrez Gene	56072 (Evidence)
UniGene	298242
DFCI	TC1580831, TC1593857, TC1599355
DoTS	DT.101220042, DT.110861492, DT.87072368, DT.91372236
NIA Mouse Gene Index	U038684
Consensus CDS Project	CCDS29529.1
International Mouse Knockout Project Status	Lgals12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034770	VEGA Gene Model | MGI Sequence Detail	10534	C57BL/6J
transcript	OTTMUST00000088364	VEGA | MGI Sequence Detail	2757	Not Applicable
polypeptide	OTTMUSP00000048148	VEGA | MGI Sequence Detail	314	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001079	Galectin, carbohydrate recognition domain
Protein Ontology	PR:000009767	galectin-12

References

(Earliest) J:74956 Hotta K, et al., Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity. J Biol Chem. 2001 Sep 7;276(36):34089-97
(Latest) J:180097 Yang RY, et al., Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18696-701
All references(30)

Other accession IDs

MGI:2147762