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Lgals12
Gene Detail
Symbol

Name
ID
Lgals12
lectin, galactose binding, soluble 12
MGI:1929094
Synonyms
galectin-12, galectin-related inhibitor of proliferation, GRIP1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:7596660-7607193 bp, - strand
From VEGA annotation of GRCm38

  10534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10462  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: galectin
Gene Tree: Lgals12

Human
homologs
Human Homolog LGALS12, lectin, galactoside-binding, soluble, 12
NCBI Gene ID 85329
neXtProt AC  NX_Q96DT0
Human Synonyms  GAL12, GRIP1
Human Chr (Location)  11q13; chr11:63506052-63516774 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity.
 
Phenotype Images(1)
Interactions
Lgals12 interacts with 169 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process apoptotic process, intrinsic apoptotic signaling pathway
Component intracellular, mitochondrion, ...
Function carbohydrate binding, lactose binding
External Resources: FuncBase
Expression
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034770 (Evidence)
Ensembl Gene ModelENSMUSG00000024972 (Evidence)
Entrez Gene56072 (Evidence)
UniGene298242
DFCITC1599355, TC1593857, TC1580831
DoTSDT.91372236, DT.101220042, DT.87072368, DT.110861492
NIA Mouse Gene IndexU038684
Consensus CDS ProjectCCDS29529.1
International Mouse Knockout Project StatusLgals12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034770 VEGA Gene Model | MGI Sequence Detail 10534 C57BL/6J ±  kb
transcript OTTMUST00000088364 VEGA | MGI Sequence Detail 2757 Not Applicable 
polypeptide OTTMUSP00000048148 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001079 Galectin, carbohydrate recognition domain
Protein Ontology PR:000009767 galectin-12
References
(Earliest) J:74956 Hotta K, et al., Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity. J Biol Chem. 2001 Sep 7;276(36):34089-97
(Latest) J:180097 Yang RY, et al., Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18696-701
All references(30)
Other
accession IDs
MGI:2147762

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory