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Rev1 Gene Detail
Summary
  • Symbol
    Rev1
  • Name
    REV1, DNA directed polymerase
  • Synonyms
    1110027I23Rik, REV1, Rev1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929074
    NCBI Gene: 56210
  • Gene Overview
    MyGene.info: REV1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:38052786-38129801 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 16.46 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    388 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929074
protein coding gene Chr1:38052786-38129920 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015949
protein coding gene Chr1:36715257-36794545 (-)
A/J MGP_AJ_G0015933
protein coding gene Chr1:35700066-35786157 (-)
AKR/J MGP_AKRJ_G0015888
protein coding gene Chr1:36197618-36274413 (-)
BALB/cJ MGP_BALBcJ_G0015887
protein coding gene Chr1:35359051-35436909 (-)
C3H/HeJ MGP_C3HHeJ_G0015720
protein coding gene Chr1:36426736-36502353 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016340
protein coding gene Chr1:38306729-38386702 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014062
protein coding gene Chr1:32686534-32760157 (-)
CAST/EiJ MGP_CASTEiJ_G0015301
protein coding gene Chr1:36281916-36365194 (-)
CBA/J MGP_CBAJ_G0015692
protein coding gene Chr1:39363501-39445982 (-)
DBA/2J MGP_DBA2J_G0015793
protein coding gene Chr1:35005438-35082368 (-)
FVB/NJ MGP_FVBNJ_G0015795
protein coding gene Chr1:34534190-34611309 (-)
LP/J MGP_LPJ_G0015863
protein coding gene Chr1:37061562-37141031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015815
protein coding gene Chr1:41511095-41592230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016387
protein coding gene Chr1:36268157-36347431 (-)
PWK/PhJ MGP_PWKPhJ_G0015084
protein coding gene Chr1:34793063-34870965 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014866
protein coding gene Chr1:36217663-36297721 (-)
WSB/EiJ MGP_WSBEiJ_G0015363
protein coding gene Chr1:36227329-36303594 (-)



Homology
more
  • Human Ortholog
    REV1, REV1, DNA directed polymerase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    REV1, REV1, DNA directed polymerase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIBP80, REV1L
  • Links
    NCBI Gene ID: 51455
    neXtProt AC: NX_Q9UBZ9
    UniProt: Q9UBZ9

  • Chr Location
    2q11.2; chr2:99400475-99490123 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit abnormal somatic hypermutation frequency of the Ig gene. Mice homozygous for a knock-out allele exhibit background-sensitive prenatal lethality and abnormal somatic hypermutation frequency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026082 Ensembl Gene Model | MGI Sequence Detail 77016 C57BL/6J ±  kb
transcript ENSMUST00000027251 Ensembl | MGI Sequence Detail 4262 Not Applicable  
polypeptide ENSMUSP00000027251 Ensembl | MGI Sequence Detail 1249 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
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MGI:1915914, MGI:2138468
References
more
  • Summaries
    All 59
    Gene Ontology 5
    Phenotypes 24
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:242573 Sasatani M, et al., Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level. Carcinogenesis. 2017 May 01;38(5):570-578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory