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Mocs1
Gene Detail
 Symbol
Name
ID
Mocs1
molybdenum cofactor synthesis 1
MGI:1928904
Synonyms 3110045D15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
25.45 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:49428362-49455435 bp, + strand
From VEGA annotation of GRCm38

  27074 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4343  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog

Protein SuperFamily: molybdenum cofactor precursor Z biosynthesis protein MoaC
Gene Tree: Mocs1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation lack the cofactor molybdopterin and enzyme activities dependent on the cofactor (including sulfate oxidase and xanthine oxidase), have curly whiskers, and die between postnatal days 1 and 11.
 
Human Diseases Modeled Using Mouse Mocs1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Mocs1 interacts with 249 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process molybdopterin cofactor biosynthetic process, Mo-molybdopterin cofactor biosynthetic process
Component molybdopterin synthase complex
Function 4 iron, 4 sulfur cluster binding, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036925 (Evidence)
Ensembl Gene ModelENSMUSG00000064120 (Evidence)
Entrez Gene56738 (Evidence)
UniGene22256
DFCITC1586020, TC1590196, TC1619973, TC1620476, TC1624106, TC1670245
DoTSDT.101351093, DT.40172109, DT.87072194
NIA Mouse Gene IndexU040824
EC4.1.99.18
Consensus CDS ProjectCCDS50143.1, CCDS57100.1
International Mouse Knockout Project StatusMocs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036925 VEGA Gene Model | MGI Sequence Detail 27074 C57BL/6J ±  kb
transcript OTTMUST00000094878 VEGA | MGI Sequence Detail 2588 Not Applicable 
polypeptide OTTMUSP00000052888 VEGA | MGI Sequence Detail 636 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(10) UniProt(8)
Polymorphisms SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR006638 Elongator protein 3/MiaB/NifB
InterPro IPR000385 MoaA/nifB/pqqE, iron-sulphur binding, conserved site
InterPro IPR023045 Molybdenum cofactor biosynthesis C
InterPro IPR023046 Molybdenum cofactor biosynthesis C, bacterial-type
InterPro IPR013483 Molybdenum cofactor biosynthesis protein A
InterPro IPR010505 Molybdenum cofactor synthesis C-terminal
InterPro IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain
InterPro IPR007197 Radical SAM
Protein Ontology PR:000010512 molybdenum cofactor biosynthesis protein 1
References (Earliest) J:66677 Gray TA, et al., Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. RNA. 2000 Jul;6(7):928-36
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Disease annotation references (1)
Other
accession IDs
MGI:1920445, MGI:2146791, MGI:2147069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory