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Mocs1 Gene Detail
Summary
  • Symbol
    Mocs1
  • Name
    molybdenum cofactor synthesis 1
  • Synonyms
    3110045D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928904
    NCBI Gene: 56738
  • Gene Overview
    MyGene.info: MOCS1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:49428364-49455435 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 25.45 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928904
protein coding gene Chr17:49428362-49455435 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023877
protein coding gene Chr17:50802270-50823198 (+)
A/J MGP_AJ_G0023837
protein coding gene Chr17:49428465-49449782 (+)
AKR/J MGP_AKRJ_G0023805
protein coding gene Chr17:49956127-49977485 (+)
BALB/cJ MGP_BALBcJ_G0023839
protein coding gene Chr17:49347159-49366995 (+)
C3H/HeJ MGP_C3HHeJ_G0023602
protein coding gene Chr17:50646455-50666856 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024282
protein coding gene Chr17:52900033-52924357 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021731
protein coding gene Chr17:46169968-46190173 (+)
CAST/EiJ MGP_CASTEiJ_G0023084
protein coding gene Chr17:50864288-50884989 (+)
CBA/J MGP_CBAJ_G0023578
protein coding gene Chr17:54822926-54844159 (+)
DBA/2J MGP_DBA2J_G0023707
protein coding gene Chr17:48190006-48209635 (+)
FVB/NJ MGP_FVBNJ_G0023673
protein coding gene Chr17:47866734-47888687 (+)
LP/J MGP_LPJ_G0023787
protein coding gene Chr17:51524885-51546444 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023701
protein coding gene Chr17:54233644-54252825 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024328
protein coding gene Chr17:50290356-50311622 (+)
PWK/PhJ MGP_PWKPhJ_G0022829
protein coding gene Chr17:47644410-47664277 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022643
protein coding gene Chr17:47208668-47228843 (+)
WSB/EiJ MGP_WSBEiJ_G0023148
protein coding gene Chr17:50882695-50903520 (+)



Homology
more
  • Human Ortholog
    MOCS1, molybdenum cofactor synthesis 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MOCS1, molybdenum cofactor synthesis 1
    Orthology source: HGNC
  • Synonyms
    MIG11, MOCOD, MOCS1A, MOCS1B
  • Links
    NCBI Gene ID: 4337
    neXtProt AC: NX_Q9NZB8
    UniProt: Q9NZB8

  • Chr Location
    6p21.2; chr6:39904258-39934551 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MOCS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack the cofactor molybdopterin and enzyme activities dependent on the cofactor (including sulfate oxidase and xanthine oxidase), have curly whiskers, and die between postnatal days 1 and 11.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56738 NCBI Gene Model | MGI Sequence Detail 27072 C57BL/6J ±  kb
transcript NM_028464 RefSeq | MGI Sequence Detail 2655 C57BL/6  
polypeptide Q5RKZ7 UniProt | EBI | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 5
Other
Accession IDs
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MGI:1920445, MGI:2146791, MGI:2147069
References
more
  • Summaries
    All 32
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:66677 Gray TA, et al., Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. RNA. 2000 Jul;6(7):928-36
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory