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Mocs1 Gene Detail
Summary
  • Symbol
    Mocs1
  • Name
    molybdenum cofactor synthesis 1
  • Synonyms
    3110045D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928904
    NCBI Gene: 56738
  • Gene Overview
    MyGene.info: MOCS1
Location & Maps
more
  • Sequence Map
    Chr17:49428362-49455435 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27074 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 25.45 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MOCS1, molybdenum cofactor synthesis 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MOCS1, molybdenum cofactor synthesis 1
    Orthology source: HGNC
  • Synonyms
    MIG11, MOCOD, MOCODA
  • Links
    NCBI Gene ID: 4337
    neXtProt AC: NX_Q9NZB8

  • Chr Location
    6p21.2; chr6:39903705-39934551 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mocs1 mouse models; 1 with human MOCS1 associations

Human Disease Mouse Models
       Molybdenum Cofactor Deficiency, Complementation Group A; MOCODA   OMIM: 252150 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack the cofactor molybdopterin and enzyme activities dependent on the cofactor (including sulfate oxidase and xanthine oxidase), have curly whiskers, and die between postnatal days 1 and 11.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036925 VEGA Gene Model | MGI Sequence Detail 27074 C57BL/6J ±  kb
transcript OTTMUST00000094878 VEGA | MGI Sequence Detail 2588 Not Applicable  
polypeptide OTTMUSP00000052888 VEGA | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    157 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 5
Other
Accession IDs
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MGI:1920445, MGI:2146791, MGI:2147069
References
more
  • Summaries
    All 32
    Diseases 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:66677 Gray TA, et al., Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. RNA. 2000 Jul;6(7):928-36
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory