Mocs1
Gene Detail

Symbol Name ID

Mocs1 molybdenum cofactor synthesis 1 MGI:1928904

Synonyms

3110045D15Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

25.45 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:49428362-49455435 bp, + strand From VEGA annotation of GRCm38   27074 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4343  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken

Protein SuperFamily: molybdenum cofactor precursor Z biosynthesis protein MoaC
Gene Tree: Mocs1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a targeted null mutation lack the cofactor molybdopterin and enzyme activities dependent on the cofactor (including sulfate oxidase and xanthine oxidase), have curly whiskers, and die between postnatal days 1 and 11.

 
Human Diseases Modeled Using Mouse Mocs1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	molybdopterin cofactor biosynthetic process, Mo-molybdopterin cofactor biosynthetic process
Component	molybdopterin synthase complex
Function	4 iron, 4 sulfur cluster binding, catalytic activity, ...

External Resources: FuncBase

Expression

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(42)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000036925 (Evidence)
Ensembl Gene Model	ENSMUSG00000064120 (Evidence)
Entrez Gene	56738 (Evidence)
UniGene	22256
DFCI	TC1586020, TC1590196, TC1619973, TC1620476, TC1624106, TC1670245
DoTS	DT.101351093, DT.40172109, DT.87072194
NIA Mouse Gene Index	U040824
EC	4.1.99.18
Consensus CDS Project	CCDS50143.1, CCDS57100.1
International Mouse Knockout Project Status	Mocs1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036925	VEGA Gene Model | MGI Sequence Detail	27074	C57BL/6J
transcript	OTTMUST00000094878	VEGA | MGI Sequence Detail	2588	Not Applicable
polypeptide	OTTMUSP00000052888	VEGA | MGI Sequence Detail	636	Not Applicable

All sequences(71) RefSeq(4) UniProt(8)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR006638	Elongator protein 3/MiaB/NifB
InterPro	IPR000385	MoaA/nifB/pqqE, iron-sulphur binding, conserved site
InterPro	IPR023045	Molybdenum cofactor biosynthesis C
InterPro	IPR023046	Molybdenum cofactor biosynthesis C, bacterial-type
InterPro	IPR013483	Molybdenum cofactor biosynthesis protein A
InterPro	IPR010505	Molybdenum cofactor synthesis C-terminal
InterPro	IPR002820	Molybdopterin cofactor biosynthesis C (MoaC) domain
InterPro	IPR007197	Radical SAM
Protein Ontology	PR:000010512	molybdenum cofactor biosynthesis protein 1

References

(Earliest) J:66677 Gray TA, et al., Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. RNA. 2000 Jul;6(7):928-36
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Other accession IDs

MGI:1920445, MGI:2146791, MGI:2147069