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Pdzk1
Gene Detail
 Symbol
Name
ID
Pdzk1
PDZ domain containing 1
MGI:1928901
Synonyms 1700023D20Rik, 2610507N21Rik, 4921513F16Rik, D3Ertd537e, mPDZK1
Feature Type protein coding gene
Genetic Map
Chromosome 3
42.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:96829284-96870926 bp, + strand
From VEGA annotation of GRCm38

  41643 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pdzk1

Human
homologs
Human Homolog PDZK1, PDZ domain containing 1
NCBI Gene ID 5174
neXtProt AC  NX_Q5T2W1
Human Synonyms  CAP70, CLAMP, NHERF3, NHERF-3, PDZD1
Human Chr (Location)  1q21; chr1:145670852-145707404 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased serum cholesterol levels.
 
Interactions
Pdzk1 interacts with 138 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process carnitine transport, establishment of protein localization to plasma membrane, ...
Component apical plasma membrane, brush border membrane, ...
Function PDZ domain binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (40)    Tissues (29)    Images (8)
Theiler Stages: 18, 20, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 6
Northern blot 2
RT-PCR 32
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024711 (Evidence)
Ensembl Gene ModelENSMUSG00000038298 (Evidence)
Entrez Gene59020 (Evidence)
NIA Mouse Gene IndexU003608
PDB2EDZ, 3NGH, 4F8K, 2D90, 3R68, 3R69
Consensus CDS ProjectCCDS17649.1
International Mouse Knockout Project StatusPdzk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024711 VEGA Gene Model | MGI Sequence Detail 41643 C57BL/6J ±  kb
transcript OTTMUST00000060818 VEGA | MGI Sequence Detail 2406 Not Applicable 
polypeptide OTTMUSP00000029719 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
Protein Ontology PR:000012528 Na(+)/H(+) exchange regulatory cofactor NHE-RF3
References (Earliest) J:66318 Kocher O, et al., PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest. 1999 Sep;79(9):1161-70
(Latest) J:191894 Giral H, et al., NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. J Biol Chem. 2012 Oct 12;287(42):35047-56
All references(62)
Other
accession IDs
MGI:1277210, MGI:1918104, MGI:1919393, MGI:1919470, MGI:2139658, MGI:2139665, MGI:2139848

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory