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Piwil1
Gene Detail
Symbol

Name
ID
Piwil1
piwi-like RNA-mediated gene silencing 1
MGI:1928897
Synonyms
MIWI
Feature Type
protein coding gene
Genetic Map
Chromosome 5
67.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:128736246-128755474 bp, + strand
From Ensembl annotation of GRCm38

  19229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIWIL1
Protein SuperFamily: piwi protein
Gene Tree: Piwil1

Human
homologs
PIWIL1, piwi-like RNA-mediated gene silencing 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9271
neXtProt AC: NX_Q96J94

Human Synonyms: CT80.1, HIWI, MIWI, PIWI

Human Chr (Location): 12q24.33; chr12:130337887-130426260 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(4) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit male sterility due to a block in spermatogenesis beginning at the round spermatid stage.
 
Interactions
Piwil1 interacts with 162 markers (Mir7-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell differentiation, gene silencing by RNA, ...
Component chromatoid body, cytoplasm, ...
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (63)    Tissues (43)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
Northern blot 11
RT-PCR 38
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PIWIL1 ; Xenbase piwil1 ; ZFIN piwil1    NEW 
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000029423 (Evidence)
Entrez Gene 57749 (Evidence)
UniGene 272720
DFCI TC1623884, TC1585959
DoTS DT.60105285, DT.102519849, DT.97372612
NIA Mouse Gene Index U006222
PDB 2XFM, 4P1Z
Consensus CDS Project CCDS19690.1
International Mouse Phenotyping Consortium Status Piwil1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029423 Ensembl Gene Model | MGI Sequence Detail 19229 C57BL/6J ±  kb
transcript ENSMUST00000086056 Ensembl | MGI Sequence Detail 3944 Not Applicable 
polypeptide ENSMUSP00000083222 Ensembl | MGI Sequence Detail 862 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003100 Argonaute/Dicer protein, PAZ
InterPro IPR012337 Ribonuclease H-like domain
InterPro IPR003165 Stem cell self-renewal protein Piwi
Protein Ontology PR:000012762 piwi-like protein 1
References
(Earliest) J:71909 Kuramochi-Miyagawa S, et al., Two mouse piwi-related genes: miwi and mili. Mech Dev. 2001 Oct;108(1-2):121-33
(Latest) J:212774 Xu K, et al., AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis. Biol Reprod. 2014 Jun;90(6):119
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory