About   Help   FAQ
Piwil1
Gene Detail
 Symbol
Name
ID
Piwil1
piwi-like RNA-mediated gene silencing 1
MGI:1928897
Synonyms MIWI
Feature Type protein coding gene
Genetic Map
Chromosome 5
67.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:128736246-128755474 bp, + strand
From NCBI annotation of GRCm38

  19229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: piwi protein
Gene Tree: Piwil1

Human
homologs
Human Homolog PIWIL1, piwi-like RNA-mediated gene silencing 1
NCBI Gene ID 9271
neXtProt AC  NX_Q96J94
Human Synonyms  CT80.1, HIWI, MIWI, PIWI
Human Chr (Location)  12q24.33; chr12:130337888-130372334 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit male sterility due to a block in spermatogenesis beginning at the round spermatid stage.
 
Interactions
Piwil1 interacts with 163 markers (Mir7-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell differentiation, gene silencing by RNA, ...
Component chromatoid body, cytoplasm, ...
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (63)    Tissues (40)    Images (9)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 14
Northern blot 11
RT-PCR 38
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000029423 (Evidence)
Entrez Gene57749 (Evidence)
UniGene272720
DFCITC1585959, TC1623884
DoTSDT.102519849, DT.60105285, DT.97372612
NIA Mouse Gene IndexU006222
PDB2XFM, 4P1Z
Consensus CDS ProjectCCDS19690.1
International Mouse Knockout Project StatusPiwil1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57749 NCBI Gene Model | MGI Sequence Detail 19229 C57BL/6J ±  kb
transcript NM_021311 RefSeq | MGI Sequence Detail 3944 C57BL/6 
polypeptide Q9JMB7 UniProt | EBI | MGI Sequence Detail 862 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003100 Argonaute/Dicer protein, PAZ
InterPro IPR012337 Ribonuclease H-like domain
InterPro IPR003165 Stem cell self-renewal protein Piwi
Protein Ontology PR:000012762 piwi-like protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:71909 Kuramochi-Miyagawa S, et al., Two mouse piwi-related genes: miwi and mili. Mech Dev. 2001 Oct;108(1-2):121-33
(Latest) J:204889 Nolde MJ, et al., Piwi genes are dispensable for normal hematopoiesis in mice. PLoS One. 2013;8(8):e71950
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory