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Isg20 Gene Detail
Summary
  • Symbol
    Isg20
  • Name
    interferon-stimulated protein
  • Synonyms
    1600023I01Rik, 2010107M23Rik, 20kDa, DnaQl, HEM45
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928895
    NCBI Gene: 57444
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:78563172-78570144 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 44.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928895
protein coding gene Chr7:78561136-78570144 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032382
protein coding gene Chr7:80751828-80758819 (+)
A/J MGP_AJ_G0032361
protein coding gene Chr7:78912099-78919076 (+)
AKR/J MGP_AKRJ_G0032297
protein coding gene Chr7:80598922-80605898 (+)
BALB/cJ MGP_BALBcJ_G0032373
protein coding gene Chr7:78613049-78620025 (+)
C3H/HeJ MGP_C3HHeJ_G0032086
protein coding gene Chr7:81263014-81269997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032865
protein coding gene Chr7:83931216-83938188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029873
protein coding gene Chr7:81466097-81473065 (+)
CAST/EiJ MGP_CASTEiJ_G0031414
protein coding gene Chr7:72109487-72116464 (+)
CBA/J MGP_CBAJ_G0032052
protein coding gene Chr7:86726790-86733771 (+)
DBA/2J MGP_DBA2J_G0032207
protein coding gene Chr7:77499783-77506764 (+)
FVB/NJ MGP_FVBNJ_G0032162
protein coding gene Chr7:77401591-77408565 (+)
LP/J MGP_LPJ_G0032288
protein coding gene Chr7:81999130-82006106 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032199
protein coding gene Chr7:86966415-86973391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032883
protein coding gene Chr7:80040828-80047804 (+)
PWK/PhJ MGP_PWKPhJ_G0031134
protein coding gene Chr7:70646432-70653394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030975
protein coding gene Chr7:67024046-67030988 (+)
WSB/EiJ MGP_WSBEiJ_G0031532
protein coding gene Chr7:80369031-80376022 (+)



Homology
more
  • Human Ortholog
    ISG20, interferon stimulated exonuclease gene 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISG20, interferon stimulated exonuclease gene 20
  • Synonyms
    CD25, HEM45
  • Links
    NCBI Gene ID: 3669
    neXtProt AC: NX_Q96AZ6
    UniProt: Q96AZ6

  • Chr Location
    15q26.1; chr15:88635632-88656483 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039236 Ensembl Gene Model | MGI Sequence Detail 6973 C57BL/6J ±  kb
transcript ENSMUST00000121645 Ensembl | MGI Sequence Detail 1087 Not Applicable  
polypeptide ENSMUSP00000112621 Ensembl | MGI Sequence Detail 300 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914966, MGI:1923946
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:343183 Jia M, et al., Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury. Mol Ther. 2023 Oct 4;31(10):3034-3051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory