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Isg20 Gene Detail
Summary
  • Symbol
    Isg20
  • Name
    interferon-stimulated protein
  • Synonyms
    1600023I01Rik, 2010107M23Rik, 20kDa, DnaQl, HEM45
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928895
    NCBI Gene: 57444
  • Gene Overview
    MyGene.info: ISG20
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:78913424-78920396 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 44.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928895
protein coding gene Chr7:78913424-78920396 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032382
protein coding gene Chr7:80751828-80758819 (+)
A/J MGP_AJ_G0032361
protein coding gene Chr7:78912099-78919076 (+)
AKR/J MGP_AKRJ_G0032297
protein coding gene Chr7:80598922-80605898 (+)
BALB/cJ MGP_BALBcJ_G0032373
protein coding gene Chr7:78613049-78620025 (+)
C3H/HeJ MGP_C3HHeJ_G0032086
protein coding gene Chr7:81263014-81269997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032865
protein coding gene Chr7:83931216-83938188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029873
protein coding gene Chr7:81466097-81473065 (+)
CAST/EiJ MGP_CASTEiJ_G0031414
protein coding gene Chr7:72109487-72116464 (+)
CBA/J MGP_CBAJ_G0032052
protein coding gene Chr7:86726790-86733771 (+)
DBA/2J MGP_DBA2J_G0032207
protein coding gene Chr7:77499783-77506764 (+)
FVB/NJ MGP_FVBNJ_G0032162
protein coding gene Chr7:77401591-77408565 (+)
LP/J MGP_LPJ_G0032288
protein coding gene Chr7:81999130-82006106 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032199
protein coding gene Chr7:86966415-86973391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032883
protein coding gene Chr7:80040828-80047804 (+)
PWK/PhJ MGP_PWKPhJ_G0031134
protein coding gene Chr7:70646432-70653394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030975
protein coding gene Chr7:67024046-67030988 (+)
WSB/EiJ MGP_WSBEiJ_G0031532
protein coding gene Chr7:80369031-80376022 (+)



Homology
more
  • Human Ortholog
    ISG20, interferon stimulated exonuclease gene 20
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ISG20, interferon stimulated exonuclease gene 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD25, HEM45
  • Links
    NCBI Gene ID: 3669
    neXtProt AC: NX_Q96AZ6
    UniProt: Q96AZ6

  • Chr Location
    15q26.1; chr15:88635614-88656344 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57444 NCBI Gene Model | MGI Sequence Detail 6973 C57BL/6J ±  kb
transcript NM_001291220 RefSeq | MGI Sequence Detail 1225 C57BL/6  
polypeptide Q9JL16 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914966, MGI:1923946
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory