Krt81 MGI Mouse Gene Detail - MGI:1928858

Symbol

Krt81
Name

keratin 81
Synonyms

Krt2-19

Feature Type

protein coding gene
IDs

MGI:1928858
NCBI Gene: 64818
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr15:101356942-101361632 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.90 cM
Mapping Data

2 experiments

SNPs within 2kb

196 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928858	protein coding gene	Chr15:101356942-101361646 (-)
129S1/SvImJ	ENSMUSG00200050779	protein coding gene	Chr15:98572327-98577017 (-)
A/J	ENSMUSG00195040275	protein coding gene	Chr15:98451609-98456299 (-)
AKR/J	ENSMUSG00220046961	protein coding gene	Chr15:98435938-98440628 (-)
BALB/cJ	ENSMUSG00180045808	protein coding gene	Chr15:98342309-98346999 (-)
C3H/HeJ	ENSMUSG00175040241	protein coding gene	Chr15:98631650-98636340 (-)
C57BL/6NJ	ENSMUSG00215050524	protein coding gene	Chr15:98397761-98402451 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020313	protein coding gene	Chr15:95155847-95160580 (-)
CAST/EiJ	ENSTCUG00005041242	protein coding gene	Chr15:97875406-97880110 (-)
CBA/J	ENSMUSG00210031177	protein coding gene	Chr15:98404837-98409527 (-)
DBA/2J	ENSMUSG00185039879	protein coding gene	Chr15:98442265-98446955 (-)
FVB/NJ	ENSMUSG00205039232	protein coding gene	Chr15:98146745-98151435 (-)
JF1/MsJ	ENSUMUG00000049296	protein coding gene	Chr15:97901466-97906151 (-)
LP/J	ENSMUSG00230032999	protein coding gene	Chr15:101795632-101800322 (-)
NOD/ShiLtJ	ENSMUSG00190048140	protein coding gene	Chr15:98381554-98386244 (-)
NZO/HlLtJ	ENSMUSG00225028023	protein coding gene	Chr15:102002353-102007057 (-)
PWK/PhJ	ENSLUMG00010040524	protein coding gene	Chr15:98113723-98118586 (-)
SPRET/EiJ	ENSMSPG00010034586	protein coding gene	Chr15:99928605-99933247 (-)
WSB/EiJ	ENSIUOG00005036423	protein coding gene	Chr15:98537260-98541964 (-)

Human Ortholog

KRT81, keratin 81

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT81, keratin 81
Synonyms

ghHkb1, Hb-1, HB1, hHAKB2-1, hHb1, K81, KRTHB1, MLN137, MNLIX2
Links

HGNC:6458

NCBI Gene ID: 3887

UniProt: Q14533
Chr Location

12q13.13; chr12:52285913-52291534 (-) GRCh38

MGI Vertebrate Homology

Krt81 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: KRT81
Gene Tree

Krt81

Diseases

6 with human KRT81,KRT83,KRT86 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				erythrokeratodermia variabilis et progressiva 5 IDs erythrokeratodermia variabilis et progressiva 5 DOID:0080251 OMIM:617756
				hair disease IDs hair disease DOID:421 MESH:D006201 NCI:C34656 UMLS_CUI:C0018500
				monilethrix 1 IDs monilethrix 1 DOID:0061145 OMIM:158000
				monilethrix 2 IDs monilethrix 2 DOID:0061152 OMIM:621169
				monilethrix 3 IDs monilethrix 3 DOID:0061153 OMIM:621170

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

34 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

4 involving Krt81
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

1
cDNA Data

3
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS49734.1

Ensembl

ENSMUSG00000067615 (Evidence)
NCBI Gene

64818

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067615	Ensembl Gene Model \| MGI Sequence Detail	4691	C57BL/6J	± kb
transcript	ENSMUST00000061185	Ensembl \| MGI Sequence Detail	1843	Not Applicable
polypeptide	ENSMUSP00000056525	Ensembl \| MGI Sequence Detail	481	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR003054 Keratin, type II

IPR032444 Keratin type II head
GlyGen

Q9ERE2 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

Genomic 9

cDNA 3

Antibodies 1

Microarray probesets 4

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MGI:2145922

Summaries

All 54

Developmental Gene Expression 1

Diseases 1

Gene Ontology 2

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Krt81:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136568	Chr15:101361639-101361651 (-)	-13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24