Pfdn5 Gene Detail

Summary

• Symbol
  Pfdn5
• Name
  prefoldin 5
• Synonyms
  1190001O17Rik, 1700010A06Rik, c-myc binding protein MM-1, D15Ertd697e, EIG-1, MM-1

• Feature Type
  protein coding gene
• IDs
  MGI:1928753
  NCBI Gene: 56612
• Gene Overview
  MyGene.info: PFDN5
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr15:102326116-102331490 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 57.48 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  69 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928753	protein coding gene	Chr15:102326116-102331873 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0022408	protein coding gene	Chr15:104497048-104502306 (+)
A/J	MGP_AJ_G0022370	protein coding gene	Chr15:100386008-100391556 (+)
AKR/J	MGP_AKRJ_G0022345	protein coding gene	Chr15:103427352-103435011 (+)
BALB/cJ	MGP_BALBcJ_G0022374	protein coding gene	Chr15:100431971-100437255 (+)
C3H/HeJ	MGP_C3HHeJ_G0022141	protein coding gene	Chr15:103502389-103507668 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022823	protein coding gene	Chr15:108379247-108386405 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020346	protein coding gene	Chr15:96160068-96165727 (+)
CAST/EiJ	MGP_CASTEiJ_G0021667	protein coding gene	Chr15:104373809-104379137 (+)
CBA/J	MGP_CBAJ_G0022110	protein coding gene	Chr15:112187130-112195329 (+)
DBA/2J	MGP_DBA2J_G0022241	protein coding gene	Chr15:99674591-99679907 (+)
FVB/NJ	MGP_FVBNJ_G0022217	protein coding gene	Chr15:98736529-98742467 (+)
LP/J	MGP_LPJ_G0022310	protein coding gene	Chr15:104653632-104658981 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022239	protein coding gene	Chr15:115752224-115757537 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022835	protein coding gene	Chr15:103452307-103460316 (+)
PWK/PhJ	MGP_PWKPhJ_G0021407	protein coding gene	Chr15:99830047-99835457 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021239	protein coding gene	Chr15:103306872-103311772 (+)
WSB/EiJ	MGP_WSBEiJ_G0021717	protein coding gene	Chr15:104085384-104090712 (+)

Homology

• Human Ortholog
  PFDN5, prefoldin subunit 5

• Vertebrate Orthologs
  10

• Human Ortholog
  PFDN5, prefoldin subunit 5
  Orthology source: HomoloGene, HGNC
• Synonyms
  MM1, MM-1, PFD5
• Links
  HGNC:8869

  NCBI Gene ID: 5204

  neXtProt AC: NX_Q99471

  UniProt: Q99471

  
  
• Chr Location
  12q13.13; chr12:53295451-53299450 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 1972
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: PFDN5
• Protein SuperFamily
  prefoldin alpha subunit
• Gene Tree
  Pfdn5
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  29 phenotypes from 1 allele in 1 genetic background
  27 phenotype references
  

• All Mutations and Alleles
  15
• Chemically induced (ENU)
  1
• Chemically induced (other)
  1
• Gene trapped
  8
• Radiation induced
  2
• Targeted
  3
• Genomic Mutations
  3 involving Pfdn5
• Incidental Mutations
  APF
• Find Mice (IMSR)
  6 strains or lines available

Mice homozygous for an ENU-induced mutation exhibit photoreceptor degeneration, central nervous system abnormalities, and male infertility.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  10
• GO References
  6

• External Resources
  FuncBase

Expression

• cDNA Data
  214
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase pfdn5
  ZFIN pfdn5

Interactions

• Pfdn5 interacts with 51 markers (Mir15a, Mir129-1, Mir129-2, ...) View All

Sequences &
Gene Models

• All Sequences
  59
• RefSeq
  2
• UniProt
  8
• CCDS
  CCDS37227.1
• UniGene
  158264

• Ensembl
  ENSMUSG00000001289 (Evidence)
• NCBI Gene
  56612

Representative Sequences			Length	Strain/Species
genomic	56612	NCBI Gene Model | MGI Sequence Detail	5375	C57BL/6J
transcript	NM_027044	RefSeq | MGI Sequence Detail	708	Not Specified
polypeptide	Q9WU28	UniProt | EBI | MGI Sequence Detail	154	Not Applicable

Protein
Information

• UniProt
  8 Sequences
• Protein Ontology
  PR:000012575 prefoldin subunit 5
  (term hierarchy)
• InterPro Domains
  IPR009053 Prefoldin
  IPR004127 Prefoldin alpha-like
  IPR011599 Prefoldin alpha subunit, archaea-type

Molecular
Reagents

• All nucleic 215

  cDNA 214

  Primer pair 1

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1277126, MGI:1913474, MGI:1916585

References

• Summaries
  All 59

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 6

  Phenotypes 27
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

TSS for Pfdn5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133374	Chr15:102326132-102326152 (+)	26 bp
Tssr133375	Chr15:102326155-102326171 (+)	47 bp
Tssr133376	Chr15:102326172-102326181 (+)	61 bp
Tssr133377	Chr15:102326369-102326387 (+)	262 bp
Tssr133378	Chr15:102326400-102326429 (+)	299 bp
Tssr133379	Chr15:102328515-102328555 (+)	2,419 bp