Pfdn5
Gene Detail

Symbol

Name
ID

Pfdn5
prefoldin 5
MGI:1928753

Synonyms

1190001O17Rik, 1700010A06Rik, c-myc binding protein MM-1, D15Ertd697e, EIG-1, MM-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15
57.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:102326116-102331873 bp, + strand From VEGA annotation of GRCm38   5758 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:1972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prefoldin alpha subunit
Gene Tree: Pfdn5

Human
homologs

Human Homolog		PFDN5, prefoldin subunit 5
NCBI Gene ID		5204
neXtProt AC		NX_Q99471
Human Synonyms		MM1, MM-1, PFD5
Human Chr (Location)		12q12; chr12:53295451-53299450 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(8) Radiation induced(1) Targeted(2)
Genomic Mutations involving Pfdn5 (1)
Incidental mutations (data from APF )
 

Mice homozygous for an ENU-induced mutation exhibit photoreceptor degeneration, central nervous system abnormalities, and male infertility.

 
Phenotype Images(2)

Interactions

Pfdn5 interacts with 51 markers (Mir15a, Mir129-1, Mir129-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (7 annotations)

Process	negative regulation of canonical Wnt signaling pathway, negative regulation of transcription, DNA-templated, ...
Component	nucleus, prefoldin complex
Function	unfolded protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)

cDNA source data(213)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(214) cDNA(213) Primer pair(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000035798 (Evidence)
Ensembl Gene Model	ENSMUSG00000001289 (Evidence)
Entrez Gene	56612 (Evidence)
UniGene	158264
DFCI	TC1572180, TC1643251
Consensus CDS Project	CCDS37227.1
International Mouse Knockout Project Status	Pfdn5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035798	VEGA Gene Model | MGI Sequence Detail	5758	C57BL/6J
transcript	OTTMUST00000091649	VEGA | MGI Sequence Detail	1062	Not Applicable
polypeptide	OTTMUSP00000050496	VEGA | MGI Sequence Detail	154	Not Applicable

All sequences(60) RefSeq(3) UniProt(8)

Polymorphisms

SNPs within 2kb(70 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009053	Prefoldin
InterPro	IPR011599	Prefoldin alpha subunit
InterPro	IPR004127	Prefoldin subunit
Protein Ontology	PR:000012575	prefoldin subunit 5

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:203848 Abe A, et al., Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation. J Biol Chem. 2013 Sep 27;288(39):27764-76
All references(39)

Other
accession IDs

MGI:1277126, MGI:1913474, MGI:1916585