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Pfdn5 Gene Detail
Summary
  • Symbol
    Pfdn5
  • Name
    prefoldin 5
  • Synonyms
    1190001O17Rik, 1700010A06Rik, c-myc binding protein MM-1, D15Ertd697e, EIG-1, MM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928753
    NCBI Gene: 56612
  • Gene Overview
    MyGene.info: PFDN5
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102326116-102331490 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928753
protein coding gene Chr15:102326116-102331873 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022408
protein coding gene Chr15:104497048-104502306 (+)
A/J MGP_AJ_G0022370
protein coding gene Chr15:100386008-100391556 (+)
AKR/J MGP_AKRJ_G0022345
protein coding gene Chr15:103427352-103435011 (+)
BALB/cJ MGP_BALBcJ_G0022374
protein coding gene Chr15:100431971-100437255 (+)
C3H/HeJ MGP_C3HHeJ_G0022141
protein coding gene Chr15:103502389-103507668 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022823
protein coding gene Chr15:108379247-108386405 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020346
protein coding gene Chr15:96160068-96165727 (+)
CAST/EiJ MGP_CASTEiJ_G0021667
protein coding gene Chr15:104373809-104379137 (+)
CBA/J MGP_CBAJ_G0022110
protein coding gene Chr15:112187130-112195329 (+)
DBA/2J MGP_DBA2J_G0022241
protein coding gene Chr15:99674591-99679907 (+)
FVB/NJ MGP_FVBNJ_G0022217
protein coding gene Chr15:98736529-98742467 (+)
LP/J MGP_LPJ_G0022310
protein coding gene Chr15:104653632-104658981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022239
protein coding gene Chr15:115752224-115757537 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022835
protein coding gene Chr15:103452307-103460316 (+)
PWK/PhJ MGP_PWKPhJ_G0021407
protein coding gene Chr15:99830047-99835457 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021239
protein coding gene Chr15:103306872-103311772 (+)
WSB/EiJ MGP_WSBEiJ_G0021717
protein coding gene Chr15:104085384-104090712 (+)



Homology
more
  • Human Ortholog
    PFDN5, prefoldin subunit 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PFDN5, prefoldin subunit 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MM1, MM-1, PFD5
  • Links
    NCBI Gene ID: 5204
    neXtProt AC: NX_Q99471
    UniProt: Q99471

  • Chr Location
    12q13.13; chr12:53295451-53299450 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Pfdn5
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for an ENU-induced mutation exhibit photoreceptor degeneration, central nervous system abnormalities, and male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56612 NCBI Gene Model | MGI Sequence Detail 5375 C57BL/6J ±  kb
transcript NM_027044 RefSeq | MGI Sequence Detail 708 Not Specified  
polypeptide Q9WU28 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 215
    cDNA 214
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1277126, MGI:1913474, MGI:1916585
References
more
  • Summaries
    All 59
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory