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Pfdn5 Gene Detail
Summary
  • Symbol
    Pfdn5
  • Name
    prefoldin 5
  • Synonyms
    1190001O17Rik, 1700010A06Rik, c-myc binding protein MM-1, D15Ertd697e, EIG-1, MM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928753
    NCBI Gene: 56612
  • Gene Overview
    MyGene.info: PFDN5
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:102326116-102331873 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5758 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.48 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PFDN5, prefoldin subunit 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PFDN5, prefoldin subunit 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MM1, MM-1, PFD5
  • Links
    NCBI Gene ID: 5204
    neXtProt AC: NX_Q99471
    UniProt: Q99471

  • Chr Location
    12q13.13; chr12:53295451-53299450 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Pfdn5
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    16 strains or lines available
Mice homozygous for an ENU-induced mutation exhibit photoreceptor degeneration, central nervous system abnormalities, and male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    213
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035798 VEGA Gene Model | MGI Sequence Detail 5758 C57BL/6J ±  kb
transcript OTTMUST00000091649 VEGA | MGI Sequence Detail 1062 Not Applicable  
polypeptide OTTMUSP00000050496 VEGA | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 214
    cDNA 213
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1277126, MGI:1913474, MGI:1916585
References
more
  • Summaries
    All 58
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory