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Slc4a8 Gene Detail
Summary
  • Symbol
    Slc4a8
  • Name
    solute carrier family 4 (anion exchanger), member 8
  • Synonyms
    KNBC-3, NDCBE, sodium bicarbonate cotransporter isoform 3 kNBC-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928745
    NCBI Gene: 59033
  • Gene Overview
    MyGene.info: SLC4A8
Location & Maps
more
  • Sequence Map
    Chr15:100761747-100823968 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62222 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.39 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC4A8, solute carrier family 4 member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC4A8, solute carrier family 4 member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NBC3, NDCBE
  • Links
    NCBI Gene ID: 9498
    neXtProt AC: NX_Q2Y0W8

  • Chr Location
    12q13.13; chr12:51391317-51515763 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Slc4a8
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal sodium and chloride ion excretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035009 VEGA Gene Model | MGI Sequence Detail 62222 C57BL/6J ±  kb
transcript OTTMUST00000089018 VEGA | MGI Sequence Detail 11790 Not Applicable  
polypeptide OTTMUSP00000048590 VEGA | MGI Sequence Detail 1089 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    747 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015163 electroneutral sodium bicarbonate exchanger 1
  • InterPro Domains
    IPR013769 Band 3 cytoplasmic domain
    IPR011531 Bicarbonate transporter, C-terminal
    IPR003020 Bicarbonate transporter, eukaryotic
    IPR016152 Phosphotransferase/anion transporter
    IPR003024 Sodium bicarbonate cotransporter
Molecular
Reagents
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  • All nucleic 46
    cDNA 44
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGI:2146219
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:202055 Siyanov V, et al., NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos. Biol Reprod. 2013 Jun;88(6):157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory