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Slc4a8
Gene Detail
Symbol

Name
ID
Slc4a8
solute carrier family 4 (anion exchanger), member 8
MGI:1928745
Synonyms
KNBC-3, NDCBE, sodium bicarbonate cotransporter isoform 3 kNBC-3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.39 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:100761747-100823968 bp, + strand
From VEGA annotation of GRCm38

  62222 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68419  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a8

Human
homologs
Human Homolog SLC4A8, solute carrier family 4, sodium bicarbonate cotransporter, member 8
NCBI Gene ID 9498
neXtProt AC  NX_Q2Y0W8
Human Synonyms  NBC3, NDCBE
Human Chr (Location)  12q13.13; chr12:51391317-51515763 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Radiation induced(1) Targeted(4)
Genomic Mutations involving Slc4a8 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal sodium and chloride ion excretion.
 
Interactions
Slc4a8 interacts with 537 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anion transport, embryo development, ...
Component integral component of membrane, membrane, ...
Function anion:anion antiporter activity, anion transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (220)    Tissues (145)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 216
RT-PCR 4
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(44) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035009 (Evidence)
Ensembl Gene ModelENSMUSG00000023032 (Evidence)
Entrez Gene59033 (Evidence)
UniGene209856
DFCITC1670857, TC1661720, TC1583669, TC1580486
DoTSDT.94123320, DT.94262735, DT.522891, DT.60103783, DT.110799968, DT.40142273, DT.110805925
Consensus CDS ProjectCCDS37214.1
International Mouse Knockout Project StatusSlc4a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035009 VEGA Gene Model | MGI Sequence Detail 62222 C57BL/6J ±  kb
transcript OTTMUST00000089018 VEGA | MGI Sequence Detail 11790 Not Applicable 
polypeptide OTTMUSP00000048590 VEGA | MGI Sequence Detail 1089 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(748 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR003024 Sodium bicarbonate cotransporter
Protein Ontology PR:000015163 electroneutral sodium bicarbonate exchanger 1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:202055 Siyanov V, et al., NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos. Biol Reprod. 2013 Jun;88(6):157
All references(43)
Other
accession IDs
MGI:2146219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory