Kcnd3
Gene Detail

Symbol Name ID

Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 MGI:1928743

Synonyms

Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.32 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:105452330-105674002 bp, + strand From VEGA annotation of GRCm38   221673 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21036  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnd3

Human homologs

Human Homolog		KCND3, potassium voltage-gated channel, Shal-related subfamily, member 3
NCBI Gene ID		3752
neXtProt AC		NX_Q9UK17
Human Synonyms		KCND3L, KCND3S, KSHIVB, KV4.3
Human Chr (Location)		1p13.3; chr1:112318454-112531777 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	cell projection, dendrite, ...
Function	A-type (transient outward) potassium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (4)   
Theiler Stages: 25, 28

Assay Type	Results
RT-PCR	6

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(30) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000026532 (Evidence)
Ensembl Gene Model	ENSMUSG00000040896 (Evidence)
Entrez Gene	56543 (Evidence)
UniGene	44530
DFCI	TC1586543, TC1601108, TC1677892
DoTS	DT.55163274, DT.91326130, DT.97336939, DT.97385792
NIA Mouse Gene Index	U003690
Consensus CDS Project	CCDS17708.1, CCDS17709.1
International Mouse Knockout Project Status	Kcnd3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026532	VEGA Gene Model | MGI Sequence Detail	221673	C57BL/6J
transcript	OTTMUST00000065647	VEGA | MGI Sequence Detail	2668	Not Applicable
polypeptide	OTTMUSP00000032744	VEGA | MGI Sequence Detail	655	Not Applicable

All sequences(46) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(1490 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR003131	Potassium channel tetramerisation-type BTB domain
InterPro	IPR003968	Potassium channel, voltage dependent, Kv
InterPro	IPR003975	Potassium channel, voltage dependent, Kv4
InterPro	IPR004056	Potassium channel, voltage dependent, Kv4.3
InterPro	IPR024587	Potassium channel, voltage dependent, Kv4, C-terminal
InterPro	IPR021645	Shal-type voltage-gated potassium channels
InterPro	IPR003091	Voltage-dependent potassium channel
Protein Ontology	PR:000000786	voltage-gated potassium channel KCND3

References

(Earliest) J:78060 Holdiman AJ, et al., 17beta-Estradiol upregulates distinct maxi-K channel transcripts in mouse uterus. Mol Cell Endocrinol. 2002 Jun 28;192(1-2):1-6
(Latest) J:186547 Granados-Fuentes D, et al., IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Neuronal Firing in the Suprachiasmatic Nucleus and Circadian Rhythms in Locomotor Activity. J Neurosci. 2012 Jul 18;32(29):10045-52
All references(40)

Other accession IDs

MGI:2139949