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Kcnd3
Gene Detail
Symbol

Name
ID
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
MGI:1928743
Synonyms
Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.32 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:105452330-105674002 bp, + strand
From VEGA annotation of GRCm38

  221673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21036  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCND3
Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnd3

Human
homologs
KCND3, potassium channel, voltage gated Shal related subfamily D, member 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3752
neXtProt AC: NX_Q9UK17

Human Synonyms: BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22

Human Chr (Location): 1p13.3; chr1:111775822-111989576 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human KCND3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function.
 
Interactions
Kcnd3 interacts with 455 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cellular response to BMP stimulus, ion transport, ...
Component caveola, cell projection, ...
Function A-type (transient outward) potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnd3 ; ZFIN kcnd3    NEW 
Molecular
reagents
All nucleic(31) cDNA(30) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000026532 (Evidence)
Ensembl Gene Model ENSMUSG00000040896 (Evidence)
Entrez Gene 56543 (Evidence)
UniGene 44530
DFCI TC1677892, TC1601108, TC1586543
DoTS DT.97336939, DT.55163274, DT.97385792, DT.91326130
NIA Mouse Gene Index U003690
Consensus CDS Project CCDS17708.1, CCDS17709.1
International Mouse Phenotyping Consortium Status Kcnd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026532 VEGA Gene Model | MGI Sequence Detail 221673 C57BL/6J ±  kb
transcript OTTMUST00000065647 VEGA | MGI Sequence Detail 2668 Not Applicable 
polypeptide OTTMUSP00000032744 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(1784 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003975 Potassium channel, voltage dependent, Kv4
InterPro IPR004056 Potassium channel, voltage dependent, Kv4.3
InterPro IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
InterPro IPR021645 Shal-type voltage-gated potassium channels
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000786 voltage-gated potassium channel KCND3
References
(Earliest) J:78060 Holdiman AJ, et al., 17beta-Estradiol upregulates distinct maxi-K channel transcripts in mouse uterus. Mol Cell Endocrinol. 2002 Jun 28;192(1-2):1-6
(Latest) J:220736 Bye CR, et al., Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1946-55
All references(43)
Other
accession IDs
MGI:2139949

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory