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Kcnd3
Gene Detail
 Symbol
Name
ID
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
MGI:1928743
Synonyms Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.32 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:105452330-105674002 bp, + strand
From VEGA annotation of GRCm38

  221673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21036  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S
Gene Tree: Kcnd3

Human
homologs
Human Homolog KCND3, potassium voltage-gated channel, Shal-related subfamily, member 3
NCBI Gene ID 3752
neXtProt AC  NX_Q9UK17
Human Synonyms  KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22
Human Chr (Location)  1p13.3; chr1:111775809-111989530 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KCND3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function.
 
Interactions
Kcnd3 interacts with 456 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to BMP stimulus, ion transport, ...
Component cell projection, dendrite, ...
Function A-type (transient outward) potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (6)   
Theiler Stages: 25, 27, 28
Assay TypeResults
RT-PCR 6
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(30) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000026532 (Evidence)
Ensembl Gene ModelENSMUSG00000040896 (Evidence)
Entrez Gene56543 (Evidence)
UniGene44530
DFCITC1586543, TC1601108, TC1677892
DoTSDT.55163274, DT.91326130, DT.97336939, DT.97385792
NIA Mouse Gene IndexU003690
Consensus CDS ProjectCCDS17708.1, CCDS17709.1
International Mouse Knockout Project StatusKcnd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026532 VEGA Gene Model | MGI Sequence Detail 221673 C57BL/6J ±  kb
transcript OTTMUST00000065647 VEGA | MGI Sequence Detail 2668 Not Applicable 
polypeptide OTTMUSP00000032744 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(1784 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003975 Potassium channel, voltage dependent, Kv4
InterPro IPR004056 Potassium channel, voltage dependent, Kv4.3
InterPro IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
InterPro IPR021645 Shal-type voltage-gated potassium channels
InterPro IPR003091 Voltage-dependent potassium channel
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000786 voltage-gated potassium channel KCND3
References (Earliest) J:78060 Holdiman AJ, et al., 17beta-Estradiol upregulates distinct maxi-K channel transcripts in mouse uterus. Mol Cell Endocrinol. 2002 Jun 28;192(1-2):1-6
(Latest) J:200210 Carrasquillo Y, et al., A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons. J Physiol. 2012 Aug 15;590(Pt 16):3877-90
All references(43)
Other
accession IDs
MGI:2139949

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory