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Kcnd3 Gene Detail
Summary
  • Symbol
    Kcnd3
  • Name
    potassium voltage-gated channel, Shal-related family, member 3
  • Synonyms
    Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928743
    NCBI Gene: 56543
  • Gene Overview
    MyGene.info: KCND3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105452330-105674002 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.32 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1778 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928743
protein coding gene Chr3:105452203-105674002 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027717
protein coding gene Chr3:106816817-107046390 (+)
A/J MGP_AJ_G0027677
protein coding gene Chr3:103401911-103621872 (+)
AKR/J MGP_AKRJ_G0027642
protein coding gene Chr3:105968434-106194929 (+)
BALB/cJ MGP_BALBcJ_G0027689
protein coding gene Chr3:103185232-103406227 (+)
C3H/HeJ MGP_C3HHeJ_G0027419
protein coding gene Chr3:106310327-106534889 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028133
protein coding gene Chr3:110813721-111046547 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025473
protein coding gene Chr3:99480033-99701902 (+)
CAST/EiJ MGP_CASTEiJ_G0026875
protein coding gene Chr3:105452511-105684929 (+)
CBA/J MGP_CBAJ_G0027394
protein coding gene Chr3:114544018-114787658 (+)
DBA/2J MGP_DBA2J_G0027536
protein coding gene Chr3:102637210-102861384 (+)
FVB/NJ MGP_FVBNJ_G0027504
protein coding gene Chr3:100573641-100794654 (+)
LP/J MGP_LPJ_G0027643
protein coding gene Chr3:108206353-108448978 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027534
protein coding gene Chr3:120665011-120903501 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028188
protein coding gene Chr3:105515529-105744344 (+)
PWK/PhJ MGP_PWKPhJ_G0026601
protein coding gene Chr3:102419218-102643354 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026422
protein coding gene Chr3:103547899-103773680 (+)
WSB/EiJ MGP_WSBEiJ_G0026955
protein coding gene Chr3:106074451-106303557 (+)



Homology
more
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22
  • Links
    NCBI Gene ID: 3752
    neXtProt AC: NX_Q9UK17
    UniProt: Q9UK17

  • Chr Location
    1p13.2; chr1:111770662-111989577 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human KCND3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Kcnd3
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040896 Ensembl Gene Model | MGI Sequence Detail 221673 C57BL/6J ±  kb
transcript ENSMUST00000118360 Ensembl | MGI Sequence Detail 2668 Not Applicable  
polypeptide ENSMUSP00000113436 Ensembl | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000786 voltage-gated potassium channel KCND3
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003975 Potassium channel, voltage dependent, Kv4
    IPR004056 Potassium channel, voltage dependent, Kv4.3
    IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
    IPR021645 Shal-type voltage-gated potassium channels, N-terminal
    IPR011333 SKP1/BTB/POZ domain superfamily
    IPR027359 Voltage-dependent channel domain superfamily
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
less
  • All nucleic 32
    cDNA 31
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2139949
References
more
  • Summaries
    All 55
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:57542 Kurschner C, et al., Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. J Neurosci. 1999 Sep 15;19(18):7770-80
  • Latest
    J:247463 Toib A, et al., Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model. Am J Physiol Heart Circ Physiol. 2017 Sep 01;313(3):H620-H630

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory