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Kcnd3 Gene Detail
Summary
  • Symbol
    Kcnd3
  • Name
    potassium voltage-gated channel, Shal-related family, member 3
  • Synonyms
    Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928743
    NCBI Gene: 56543
  • Gene Overview
    MyGene.info: KCND3
Location & Maps
more
  • Sequence Map
    Chr3:105452330-105674002 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      221673 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.32 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22
  • Links
    NCBI Gene ID: 3752
    neXtProt AC: NX_Q9UK17

  • Chr Location
    1p13.3; chr1:111775822-111989576 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human KCND3 associations

Human Disease Mouse Models
       Brugada Syndrome 9; BRGDA9   OMIM: 616399
Spinocerebellar Ataxia 19; SCA19   OMIM: 607346
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Kcnd3
  • Incidental Mutations
Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026532 VEGA Gene Model | MGI Sequence Detail 221673 C57BL/6J ±  kb
transcript OTTMUST00000065647 VEGA | MGI Sequence Detail 2668 Not Applicable  
polypeptide OTTMUSP00000032744 VEGA | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1778 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000000786 voltage-gated potassium channel KCND3
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR005821 Ion transport domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR003968 Potassium channel, voltage dependent, Kv
    IPR003975 Potassium channel, voltage dependent, Kv4
    IPR004056 Potassium channel, voltage dependent, Kv4.3
    IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
    IPR021645 Shal-type voltage-gated potassium channels, N-terminal
    IPR011333 SKP1/BTB/POZ domain
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
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  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2139949
References
more
  • Summaries
    All 42
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:78060 Holdiman AJ, et al., 17beta-Estradiol upregulates distinct maxi-K channel transcripts in mouse uterus. Mol Cell Endocrinol. 2002 Jun 28;192(1-2):1-6
  • Latest
    J:232973 Hirst CS, et al., Ion channel expression in the developing enteric nervous system. PLoS One. 2015;10(3):e0123436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory