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Dnajb2 Gene Detail
Summary
  • Symbol
    Dnajb2
  • Name
    DnaJ heat shock protein family (Hsp40) member B2
  • Synonyms
    2700059H22Rik, Dnajb10, mDj8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928739
    NCBI Gene: 56812
  • Gene Overview
    MyGene.info: DNAJB2
Location & Maps
more
  • Sequence Map
    Chr1:75236406-75245692 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9287 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.64 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNAJB2, DnaJ heat shock protein family (Hsp40) member B2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAJB2, DnaJ heat shock protein family (Hsp40) member B2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMT2T, DSMA5, HSJ1, HSJ-1, HSPF3
  • Links
    NCBI Gene ID: 3300
    neXtProt AC: NX_P25686

  • Chr Location
    2q35; chr2:219279318-219286900 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4902
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DNAJB2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human DNAJB2 associations

Human Disease Mouse Models
       Charcot-Marie-Tooth Disease, Axonal, Type 2t; CMT2T   OMIM: 617017
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 5; DSMA5   OMIM: 614881
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Dnajb2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048595 VEGA Gene Model | MGI Sequence Detail 9287 C57BL/6J ±  kb
transcript OTTMUST00000124478 VEGA | MGI Sequence Detail 3066 Not Applicable  
polypeptide OTTMUSP00000067716 VEGA | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000029422 DnaJ homolog subfamily B member 2
  • InterPro Domains
    IPR001623 DnaJ domain
    IPR018253 DnaJ domain, conserved site
    IPR003903 Ubiquitin interacting motif
Molecular
Reagents
less
  • All nucleic 80
    cDNA 80

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923843
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 1
    Phenotypes 21
  • Earliest
    J:67228 Ohtsuka K, et al., Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell Stress Chaperones. 2000 Apr;5(2):98-112
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory