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Tdo2
Gene Detail
 Symbol
Name
ID
Tdo2
tryptophan 2,3-dioxygenase
MGI:1928486
Synonyms chky, TDO, TO
Feature Type protein coding gene
Genetic Map
Chromosome 3
35.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:81957090-81975750 bp, - strand
From VEGA annotation of GRCm38

  18661 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tdo2

Human
homologs
Human Homolog TDO2, tryptophan 2,3-dioxygenase
NCBI Gene ID 6999
neXtProt AC  NX_P48775
Human Synonyms  TDO, TO, TPH2, TRPO
Human Chr (Location)  4q31-q32; chr4:155903693-155920406 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased plasma and brain levels of tryptophan, increased serotonin levels in the brain, decreased anxiety-related behavior, increased neuronal precursor proliferation and accelerated neurogenesis in the granule cell layer of the olfactory bulb.
 
Phenotype Images(2)
Interactions
Tdo2 interacts with 250 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process oxidation-reduction process, tryptophan catabolic process, ...
Function amino acid binding, dioxygenase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (116)    Tissues (98)    Images (1)
Theiler Stages: 20, 22, 26, 27, 28
Assay TypeResults
RNA in situ 94
Northern blot 22
cDNA source data(98)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) cDNA(99) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023136 (Evidence)
Ensembl Gene ModelENSMUSG00000028011 (Evidence)
Entrez Gene56720 (Evidence)
UniGene258622
DFCITC1578118, TC1711443
DoTSDT.101362775, DT.101370547, DT.55101197
NIA Mouse Gene IndexU024187, U202164
EC1.13.11.11
Consensus CDS ProjectCCDS17427.1
International Mouse Knockout Project StatusTdo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023136 VEGA Gene Model | MGI Sequence Detail 18661 C57BL/6J ±  kb
transcript OTTMUST00000055914 VEGA | MGI Sequence Detail 2979 Not Applicable 
polypeptide OTTMUSP00000026825 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004981 Tryptophan 2,3-dioxygenase
Protein Ontology PR:000016214 tryptophan 2,3-dioxygenase
References (Earliest) J:54660 Kamiya A, et al., Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999 Apr 15;18(8):2127-36
(Latest) J:203966 Mazarei G, et al., Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. J Neurochem. 2013 Dec;127(6):852-67
All references(40)
Other
accession IDs
MGI:2139552, MGI:3617202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory