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Tdo2
Gene Detail
Symbol

Name
ID
Tdo2
tryptophan 2,3-dioxygenase
MGI:1928486
Synonyms
chky, TDO, TO
Feature Type
protein coding gene
Genetic Map
Chromosome 3
35.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:81957090-81976202 bp, - strand
From VEGA annotation of GRCm38

  19113 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TDO2
Gene Tree: Tdo2

Human
homologs
TDO2, tryptophan 2,3-dioxygenase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6999
neXtProt AC: NX_P48775

Human Synonyms: TDO, TO, TPH2, TRPO

Human Chr (Location): 4q31-q32; chr4:155903693-155920406 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased plasma and brain levels of tryptophan, increased serotonin levels in the brain, decreased anxiety-related behavior, increased neuronal precursor proliferation and accelerated neurogenesis in the granule cell layer of the olfactory bulb.
 
Phenotype Images(2)
Interactions
Tdo2 interacts with 250 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process oxidation-reduction process, tryptophan catabolic process, ...
Function amino acid binding, dioxygenase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (116)    Tissues (98)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 22
cDNA source data(98)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tdo2    NEW 
Molecular
reagents
All nucleic(100) cDNA(99) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000023136 (Evidence)
Ensembl Gene Model ENSMUSG00000028011 (Evidence)
Entrez Gene 56720 (Evidence)
UniGene 258622
DFCI TC1578118, TC1711443
DoTS DT.101370547, DT.101362775, DT.55101197
NIA Mouse Gene Index U202164, U024187
EC 1.13.11.11
Consensus CDS Project CCDS17427.1
International Mouse Phenotyping Consortium Status Tdo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023136 VEGA Gene Model | MGI Sequence Detail 19113 C57BL/6J ±  kb
transcript OTTMUST00000055914 VEGA | MGI Sequence Detail 3431 Not Applicable 
polypeptide OTTMUSP00000026825 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(212 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004981 Tryptophan 2,3-dioxygenase
Protein Ontology PR:000016214 tryptophan 2,3-dioxygenase
References
(Earliest) J:54660 Kamiya A, et al., Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999 Apr 15;18(8):2127-36
(Latest) J:216882 Too LK, et al., The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behav Brain Res. 2014 Aug 15;270:179-95
All references(40)
Other
accession IDs
MGI:2139552, MGI:3617202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory