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Mlycd
Gene Detail
Symbol

Name
ID
Mlycd
malonyl-CoA decarboxylase
MGI:1928485
Synonyms
Mcd
Feature Type
protein coding gene
Genetic Map
Chromosome 8
67.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:119394878-119411102 bp, + strand
From VEGA annotation of GRCm38

  16225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MLYCD
Protein SuperFamily: malonyl-CoA decarboxylase
Gene Tree: Mlycd

Human
homologs
MLYCD, malonyl-CoA decarboxylase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23417
neXtProt AC: NX_O95822

Human Synonyms: MCD

Human Chr (Location): 16q24; chr16:83899125-83916182 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MLYCD

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit altered cardiac metabolism following ischemia and improved recovery.
 
Interactions
Mlycd interacts with 93 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process acetyl-CoA biosynthetic process, fatty acid biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function carboxy-lyase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (111)    Tissues (97)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
Western blot 3
RT-PCR 2
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mlycd    NEW 
Molecular
reagents
All nucleic(58) cDNA(57) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026334 (Evidence)
Ensembl Gene Model ENSMUSG00000074064 (Evidence)
Entrez Gene 56690 (Evidence)
UniGene 423037
DFCI TC1576234, TC1743045
DoTS DT.103577486, DT.531338, DT.94348097, DT.97392969
NIA Mouse Gene Index U360120, U362457
EC 4.1.1.9
Consensus CDS Project CCDS22703.1
International Mouse Phenotyping Consortium Status Mlycd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026334 VEGA Gene Model | MGI Sequence Detail 16225 C57BL/6J ±  kb
transcript OTTMUST00000065124 VEGA | MGI Sequence Detail 2128 Not Applicable 
polypeptide OTTMUSP00000032416 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(17) UniProt(3)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007956 Malonyl-CoA decarboxylase
Protein Ontology PR:000010461 malonyl-CoA decarboxylase, mitochondrial
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:219549 Masoud WG, et al., Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation. Cardiovasc Res. 2014 Jan 1;101(1):30-8
All references(42)
Other
accession IDs
MGI:2142507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory