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Mlycd Gene Detail
Summary
  • Symbol
    Mlycd
  • Name
    malonyl-CoA decarboxylase
  • Synonyms
    Mcd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928485
    NCBI Gene: 56690
Location & Maps
more
  • Sequence Map
    Chr8:119394878-119411102 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16225 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 67.64 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MLYCD, malonyl-CoA decarboxylase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MLYCD, malonyl-CoA decarboxylase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MCD
  • Links
    NCBI Gene ID: 23417
    neXtProt AC: NX_O95822

  • Chr Location
    16q24; chr16:83899125-83916182 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MLYCD associations

Human Disease Mouse Models
       Malonyl-CoA Decarboxylase Deficiency   OMIM: 248360
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null allele exhibit altered cardiac metabolism following ischemia and improved recovery.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026334 VEGA Gene Model | MGI Sequence Detail 16225 C57BL/6J ±  kb
transcript OTTMUST00000065124 VEGA | MGI Sequence Detail 2128 Not Applicable  
polypeptide OTTMUSP00000032416 VEGA | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010461 malonyl-CoA decarboxylase, mitochondrial
  • EC
  • InterPro Domains
    IPR007956 Malonyl-CoA decarboxylase
Molecular
Reagents
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  • All nucleic 58
    cDNA 57
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142507
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:219549 Masoud WG, et al., Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation. Cardiovasc Res. 2014 Jan 1;101(1):30-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory