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Mlycd
Gene Detail
 Symbol
Name
ID
Mlycd
malonyl-CoA decarboxylase
MGI:1928485
Synonyms Mcd
Feature Type protein coding gene
Genetic Map
Chromosome 8
67.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:119394878-119411102 bp, + strand
From VEGA annotation of GRCm38

  16225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: malonyl-CoA decarboxylase
Gene Tree: Mlycd

Human
homologs
Human Homolog MLYCD, malonyl-CoA decarboxylase
NCBI Gene ID 23417
neXtProt AC  NX_O95822
Human Synonyms  MCD
Human Chr (Location)  16q24; chr16:83899125-83916182 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MLYCD
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit altered cardiac metabolism following ischemia and improved recovery.
 
Interactions
Mlycd interacts with 93 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process acetyl-CoA biosynthetic process, fatty acid biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function carboxy-lyase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (111)    Tissues (97)    Images (17)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 106
Western blot 3
RT-PCR 2
cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(57) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026334 (Evidence)
Ensembl Gene ModelENSMUSG00000074064 (Evidence)
Entrez Gene56690 (Evidence)
UniGene423037
DFCITC1576234, TC1743045
DoTSDT.103577486, DT.531338, DT.94348097, DT.97392969
NIA Mouse Gene IndexU360120, U362457
EC4.1.1.9
Consensus CDS ProjectCCDS22703.1
International Mouse Knockout Project StatusMlycd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026334 VEGA Gene Model | MGI Sequence Detail 16225 C57BL/6J ±  kb
transcript OTTMUST00000065124 VEGA | MGI Sequence Detail 2128 Not Applicable 
polypeptide OTTMUSP00000032416 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(20) UniProt(3)
Polymorphisms SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007956 Malonyl-CoA decarboxylase
Protein Ontology PR:000010461 malonyl-CoA decarboxylase, mitochondrial
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:211646 Liu Y, et al., Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2414-22
All references(42)
Other
accession IDs
MGI:2142507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory