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Lgals8
Gene Detail
Symbol

Name
ID
Lgals8
lectin, galactose binding, soluble 8
MGI:1928481
Synonyms
1200015E08Rik, D13Ertd524e, Lgals-8
Feature Type
protein coding gene
Genetic Map
Chromosome 13
4.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:12439415-12464944 bp, - strand
From VEGA annotation of GRCm38

  25530 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LGALS8
Protein SuperFamily: galectin
Gene Tree: Lgals8

Human
homologs
LGALS8, lectin, galactoside-binding, soluble, 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3964
neXtProt AC: NX_O00214

Human Synonyms: Gal-8, PCTA1, PCTA-1, Po66-CBP

Human Chr (Location): 1q43; chr1:236518214-236552981 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in hyperactivity
 
Interactions
Lgals8 interacts with 211 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process plasma cell differentiation, T cell costimulation
Component cytoplasm, extracellular exosome, ...
Function carbohydrate binding
External Resources: FuncBase
Expression
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lgals8    NEW 
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000033741 (Evidence)
Ensembl Gene Model ENSMUSG00000057554 (Evidence)
Entrez Gene 56048 (Evidence)
DFCI TC1574996, TC1596956, TC1683963, TC1700962
NIA Mouse Gene Index U034513
Consensus CDS Project CCDS36592.1, CCDS70430.1, CCDS70431.1
International Mouse Phenotyping Consortium Status Lgals8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033741 VEGA Gene Model | MGI Sequence Detail 25530 C57BL/6J ±  kb
transcript OTTMUST00000085014 VEGA | MGI Sequence Detail 1148 Not Applicable 
polypeptide OTTMUSP00000045883 VEGA | MGI Sequence Detail 325 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(26) UniProt(5)
Polymorphisms
PCR(2) : SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR030638 Galectin-8
InterPro IPR001079 Galectin, carbohydrate recognition domain
Protein Ontology PR:000009775 galectin-8
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:204419 Takeuchi T, et al., Mammalian galectins bind galactosebeta1-4fucose disaccharide, a unique structural component of protostomial N-type glycoproteins. Biochem Biophys Res Commun. 2013 Jul 5;436(3):509-13
All references(37)
Other
accession IDs
MGI:1261882, MGI:1918987, MGI:2145217

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory