Lgals8
Gene Detail

Symbol Name ID

Lgals8 lectin, galactose binding, soluble 8 MGI:1928481

Synonyms

1200015E08Rik, D13Ertd524e, Lgals-8

Feature Type

protein coding gene

Genetic Map

Chromosome 13

4.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:12439415-12464944 bp, - strand From VEGA annotation of GRCm38   25530 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Lgals8 ± 2 cM)

Protein SuperFamily: galectin
Gene Tree: Lgals8

Human ortholog

LGALS8 lectin, galactoside-binding, soluble, 8 NCBI Gene ID 3964
Human Synonyms: Gal-8, PCTA1, PCTA-1, Po66-CBP
Human Chr1:236681565-236712996 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(1) Gene trapped(5)
 

Homozygous mutation of this gene results in hyperactivity

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	plasma cell differentiation, T cell costimulation
Component	cytoplasm
Function	carbohydrate binding

External Resources: FuncBase

Expression

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000033741 (Evidence)
Ensembl Gene Model	ENSMUSG00000057554 (Evidence)
Entrez Gene	56048 (Evidence)
DFCI	TC1574996, TC1596956, TC1683963, TC1700962
NIA Mouse Gene Index	U034513
Consensus CDS Project	CCDS36592.1
International Mouse Knockout Project Status	Lgals8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033741	VEGA Gene Model | MGI Sequence Detail	25530	C57BL/6J
transcript	OTTMUST00000085014	VEGA | MGI Sequence Detail	1148	Not Applicable
polypeptide	OTTMUSP00000045883	VEGA | MGI Sequence Detail	325	Not Applicable

All sequences(76) RefSeq(4) UniProt(5)

Polymorphisms

PCR(2) : SNPs(152 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001079	Galectin, carbohydrate recognition domain
Protein Ontology	PR:000009775	galectin-8

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183108 Tribulatti MV, et al., Redundant and antagonistic functions of galectin-1, -3, and -8 in the elicitation of T cell responses. J Immunol. 2012 Apr 1;188(7):2991-9
All references(37)

Other accession IDs

MGI:1261882, MGI:1918987, MGI:2145217