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Lgals8 Gene Detail
Summary
  • Symbol
    Lgals8
  • Name
    lectin, galactose binding, soluble 8
  • Synonyms
    1200015E08Rik, D13Ertd524e, Lgals-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928481
    NCBI Gene: 56048
  • Gene Overview
    MyGene.info: LGALS8
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:12439415-12464944 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 4.64 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928481
protein coding gene Chr13:12439402-12464977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020231
protein coding gene Chr13:9200898-9222399 (-)
A/J MGP_AJ_G0020187
protein coding gene Chr13:9025976-9047972 (-)
AKR/J MGP_AKRJ_G0020162
protein coding gene Chr13:9226396-9248040 (-)
BALB/cJ MGP_BALBcJ_G0020170
protein coding gene Chr13:9011464-9032675 (-)
C3H/HeJ MGP_C3HHeJ_G0019974
protein coding gene Chr13:9356947-9378399 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020617
protein coding gene Chr13:9624377-9645144 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018224
protein coding gene Chr13:8856475-8878206 (-)
CAST/EiJ MGP_CASTEiJ_G0019512
protein coding gene Chr13:9067210-9090219 (-)
CBA/J MGP_CBAJ_G0019941
protein coding gene Chr13:9879297-9900378 (-)
DBA/2J MGP_DBA2J_G0020058
protein coding gene Chr13:8846886-8867411 (-)
FVB/NJ MGP_FVBNJ_G0020043
protein coding gene Chr13:8664572-8685811 (-)
LP/J MGP_LPJ_G0020132
protein coding gene Chr13:9302590-9323102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020079
protein coding gene Chr13:10165645-10185183 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020645
protein coding gene Chr13:9126423-9149203 (-)
PWK/PhJ MGP_PWKPhJ_G0019275
protein coding gene Chr13:8882854-8904681 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019082
protein coding gene Chr13:9105166-9126369 (-)
WSB/EiJ MGP_WSBEiJ_G0019572
protein coding gene Chr13:9092127-9113012 (-)



Homology
more
  • Human Ortholog
    LGALS8, galectin 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LGALS8, galectin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gal-8, PCTA1, PCTA-1, Po66-CBP
  • Links
    NCBI Gene ID: 3964
    neXtProt AC: NX_O00214
    UniProt: O00214

  • Chr Location
    1q43; chr1:236518214-236552981 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced VEGF-C-induced lymphangiogenesis, and ameliorated corneal pathology and lymphangiogenesis in a model of herpes simplex virus keratitis. Mice homozygous for a gene trapped allele exhibit hyperactivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057554 Ensembl Gene Model | MGI Sequence Detail 25530 C57BL/6J ±  kb
transcript ENSMUST00000144283 Ensembl | MGI Sequence Detail 1148 Not Applicable  
polypeptide ENSMUSP00000114200 Ensembl | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR030638 Galectin-8
    IPR001079 Galectin, carbohydrate recognition domain
Molecular
Reagents
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  • All nucleic 24
    cDNA 21
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGI:1261882, MGI:1918987, MGI:2145217
References
more
  • Summaries
    All 42
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:262039 Jia J, et al., Galectins Control mTOR in Response to Endomembrane Damage. Mol Cell. 2018 Apr 5;70(1):120-135.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory