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Lgals8 Gene Detail
Summary
  • Symbol
    Lgals8
  • Name
    lectin, galactose binding, soluble 8
  • Synonyms
    1200015E08Rik, D13Ertd524e, Lgals-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928481
    NCBI Gene: 56048
  • Gene Overview
    MyGene.info: LGALS8
Location & Maps
more
  • Sequence Map
    Chr13:12439415-12464944 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25530 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 4.64 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    LGALS8, galectin 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LGALS8, galectin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gal-8, PCTA1, PCTA-1, Po66-CBP
  • Links
    NCBI Gene ID: 3964
    neXtProt AC: NX_O00214

  • Chr Location
    1q43; chr1:236518214-236552981 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    5
  • Targeted
    1
  • Incidental Mutations
Homozygous mutation of this gene results in hyperactivity
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033741 VEGA Gene Model | MGI Sequence Detail 25530 C57BL/6J ±  kb
transcript OTTMUST00000085014 VEGA | MGI Sequence Detail 1148 Not Applicable  
polypeptide OTTMUSP00000045883 VEGA | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    187 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 20
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGI:1261882, MGI:1918987, MGI:2145217
References
more
  • Summaries
    All 36
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:222956 Vinik Y, et al., The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice. Elife. 2015;4:e05914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory