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Brinp1 Gene Detail
Summary
  • Symbol
    Brinp1
  • Name
    bone morphogenic protein/retinoic acid inducible neural specific 1
  • Synonyms
    Dbc1, Dbccr1, Fam5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928478
    NCBI Gene: 56710
  • Gene Overview
    MyGene.info: BRINP1
Location & Maps
more
  • Sequence Map
    Chr4:68761514-68954397 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      192884 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 35.03 cM, cytoband C2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BRINP1, BMP/retinoic acid inducible neural specific 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRINP1, BMP/retinoic acid inducible neural specific 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBC1, DBCCR1, FAM5A
  • Links
    NCBI Gene ID: 1620
    neXtProt AC: NX_O60477

  • Chr Location
    9q33.1; chr9:119166630-119369461 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8754
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BRINP1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Brinp1 mouse models

Human Disease Mouse Models
       Attention Deficit-Hyperactivity Disorder; ADHD   OMIM: 143465 View 1 model
Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased adult neurogenesis in the subgranular zone of the dentate gyrus, altered neuronal differentiation in the hippocampus, and behavioral anomalies such as hyperactivity, reduced anxiety-like behaviors, poor social interaction, and a slight deficit in working memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000310 VEGA Gene Model | MGI Sequence Detail 192884 C57BL/6J ±  kb
transcript OTTMUST00000000793 VEGA | MGI Sequence Detail 3212 Not Applicable  
polypeptide OTTMUSP00000000357 VEGA | MGI Sequence Detail 760 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    999 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006291 BMP/retinoic acid-inducible neural-specific protein 1
  • InterPro Domains
    IPR033237 BMP/retinoic acid-inducible neural-specific protein
    IPR020864 Membrane attack complex component/perforin (MACPF) domain
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:231288 Berkowicz SR, et al., Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density. Mol Autism. 2016;7:22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory