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Clip1 Gene Detail
Summary
  • Symbol
    Clip1
  • Name
    CAP-GLY domain containing linker protein 1
  • Synonyms
    1110007I12Rik, 4631429H07Rik, Clip 170, CLIP-170, Clip50, cytoplasmic linker protein 50, restin, Rsn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928401
    NCBI Gene: 56430
  • Gene Overview
    MyGene.info: CLIP1
Location & Maps
more
  • Sequence Map
    Chr5:123577795-123684618 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      106824 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.06 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLIP1, CAP-Gly domain containing linker protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLIP1, CAP-Gly domain containing linker protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLIP, CLIP170, CLIP-170, CYLN1, RSN
  • Links
    NCBI Gene ID: 6249
    neXtProt AC: NX_P30622

  • Chr Location
    12q24.3; chr12:122271432-122422632 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 74455
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CLIP1
  • Gene Tree
    Clip1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Clip1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a targeted allele display reduced male fertility and teratozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    18
  • Tissues
    13
  • cDNA Data
    14
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025900 VEGA Gene Model | MGI Sequence Detail 106824 C57BL/6J ±  kb
transcript OTTMUST00000063863 VEGA | MGI Sequence Detail 4387 Not Applicable  
polypeptide OTTMUSP00000031659 VEGA | MGI Sequence Detail 1437 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    623 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 14
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1915807, MGI:1921596, MGI:2141102, MGI:2141322
References
more
  • Summaries
    All 50
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:234717 Nirschl JJ, et al., alpha-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep. 2016 Mar 22;14(11):2637-52
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory