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Clip1 Gene Detail
Summary
  • Symbol
    Clip1
  • Name
    CAP-GLY domain containing linker protein 1
  • Synonyms
    1110007I12Rik, 4631429H07Rik, Clip 170, CLIP-170, Clip50, cytoplasmic linker protein 50, restin, Rsn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928401
    NCBI Gene: 56430
  • Gene Overview
    MyGene.info: CLIP1
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123577794-123684606 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928401
 protein coding gene Chr5:123577794-123684618 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030076
 protein coding gene Chr5:127317644-127432360 (-)
A/J MGP_AJ_G0030041
 protein coding gene Chr5:122033082-122140659 (-)
AKR/J MGP_AKRJ_G0029977
 protein coding gene Chr5:125968147-126082192 (-)
BALB/cJ MGP_BALBcJ_G0030052
 protein coding gene Chr5:123364922-123471254 (-)
C3H/HeJ MGP_C3HHeJ_G0029769
 protein coding gene Chr5:126576152-126687819 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030505
 protein coding gene Chr5:132250191-132378466 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027731
 protein coding gene Chr5:116569731-116683655 (-)
CAST/EiJ MGP_CASTEiJ_G0029178
 protein coding gene Chr5:125675898-125793545 (-)
CBA/J MGP_CBAJ_G0029739
 protein coding gene Chr5:137437953-137564789 (-)
DBA/2J MGP_DBA2J_G0029889
 protein coding gene Chr5:122045034-122156907 (-)
FVB/NJ MGP_FVBNJ_G0029845
 protein coding gene Chr5:121087225-121198747 (-)
LP/J MGP_LPJ_G0029978
 protein coding gene Chr5:127855310-127972783 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029876
 protein coding gene Chr5:141071031-141188007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030546
 protein coding gene Chr5:125564268-125681136 (-)
PWK/PhJ MGP_PWKPhJ_G0028892
 protein coding gene Chr5:120866466-120975614 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028729
 protein coding gene Chr5:123232635-123352105 (-)
WSB/EiJ MGP_WSBEiJ_G0029253
 protein coding gene Chr5:126241688-126369988 (-)



Homology
more
  • Human Ortholog
    CLIP1, CAP-Gly domain containing linker protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLIP1, CAP-Gly domain containing linker protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLIP, CLIP170, CLIP-170, CYLN1, RSN
  • Links
    NCBI Gene ID: 6249
    neXtProt AC: NX_P30622
    UniProt: P30622

  • Chr Location
    12q24.31; chr12:122271432-122422956 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 74455
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLIP1
  • Gene Tree
    Clip1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele display reduced male fertility and teratozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    18
  • Tissues
    13
  • cDNA Data
    16
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56430 NCBI Gene Model | MGI Sequence Detail 106813 C57BL/6J ±  kb
    transcript NM_019765 RefSeq | MGI Sequence Detail 5877 C57BL/6  
    polypeptide Q922J3 UniProt | EBI | MGI Sequence Detail 1391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915807, MGI:1921596, MGI:2141102, MGI:2141322
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:256894 Jakka P, et al., Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. J Immunol. 2018 Jan 15;200(2):704-714
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/03/2019
    MGI 6.14     		The Jackson Laboratory