Clip1 MGI Mouse Gene Detail - MGI:1928401 - CAP-GLY domain containing linker protein 1

Clip1 Gene Detail

Symbol

Clip1
Name

CAP-GLY domain containing linker protein 1
Synonyms

1110007I12Rik, 4631429H07Rik, Clip 170, CLIP-170, Clip50, cytoplasmic linker protein 50, restin, Rsn

Feature Type

protein coding gene
IDs

MGI:1928401
NCBI Gene: 56430
Gene Overview

MyGene.info: CLIP1

Sequence Map

Chr5:123577795-123684618 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

106824 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 63.06 cM
Mapping Data

2 experiments

Human Ortholog

CLIP1, CAP-Gly domain containing linker protein 1

Vertebrate Orthologs

9

Human Ortholog

CLIP1, CAP-Gly domain containing linker protein 1
Orthology source: HomoloGene, HGNC
Synonyms

CLIP, CLIP170, CLIP-170, CYLN1, RSN
Links

HGNC:10461

NCBI Gene ID: 6249

neXtProt AC: NX_P30622

UniProt: P30622
Chr Location

12q24.31; chr12:122271432-122422956 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 74455
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CLIP1
Gene Tree

Clip1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Clip1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

Mice homozygous for a targeted allele display reduced male fertility and teratozoospermia.

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All GO Annotations

31
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

18
Tissues

13
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clip1

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Clip1 interacts with 264 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

149
RefSeq

70
UniProt

10
CCDS

CCDS19667.1, CCDS71663.1, CCDS84958.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000025900	VEGA Gene Model \| MGI Sequence Detail	106824	C57BL/6J	± kb
transcript	OTTMUST00000063863	VEGA \| MGI Sequence Detail	4387	Not Applicable
polypeptide	OTTMUSP00000031659	VEGA \| MGI Sequence Detail	1437	Not Applicable

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SNPs within 2kb

623 from dbSNP Build 142

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UniProt

10 Sequences
PDB

2CP7
InterPro Domains

IPR000938 CAP Gly-rich domain

IPR032108 CLIP1, zinc knuckle

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All nucleic 18

cDNA 14

Primer pair 3

Other 1

Microarray probesets 7

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MGI:1915807, MGI:1921596, MGI:2141102, MGI:2141322

Summaries

All 57

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:236302 Zhang X, et al., Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25;166(5):1147-1162.e15

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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