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Il17b Gene Detail
Summary
  • Symbol
    Il17b
  • Name
    interleukin 17B
  • Synonyms
    1110006O16Rik, 1700006N07Rik, Zcyto7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928397
    NCBI Gene: 56069
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61687935-61692538 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.67 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928397
protein coding gene Chr18:61684887-61692538 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024482
protein coding gene Chr18:61588604-61593146 (+)
A/J MGP_AJ_G0024449
protein coding gene Chr18:58944789-58949413 (+)
AKR/J MGP_AKRJ_G0024419
protein coding gene Chr18:60566656-60571263 (+)
BALB/cJ MGP_BALBcJ_G0024448
protein coding gene Chr18:59070865-59075760 (+)
C3H/HeJ MGP_C3HHeJ_G0024216
protein coding gene Chr18:60799729-60804256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024895
protein coding gene Chr18:63261540-63266139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022326
protein coding gene Chr18:58490219-58494629 (+)
CAST/EiJ MGP_CASTEiJ_G0023689
protein coding gene Chr18:60683595-60688165 (+)
CBA/J MGP_CBAJ_G0024186
protein coding gene Chr18:65310751-65318619 (+)
DBA/2J MGP_DBA2J_G0024316
protein coding gene Chr18:58614552-58619132 (+)
FVB/NJ MGP_FVBNJ_G0024282
protein coding gene Chr18:58026461-58031459 (+)
LP/J MGP_LPJ_G0024399
protein coding gene Chr18:61446176-61450775 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024311
protein coding gene Chr18:66879515-66884113 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024942
protein coding gene Chr18:60780459-60785055 (+)
PWK/PhJ MGP_PWKPhJ_G0023432
protein coding gene Chr18:58845710-58850400 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023238
protein coding gene Chr18:61001159-61006916 (+)
WSB/EiJ MGP_WSBEiJ_G0023753
protein coding gene Chr18:60628587-60634258 (+)



Homology
more
  • Human Ortholog
    IL17B, interleukin 17B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IL17B, interleukin 17B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-17B, IL-20, NIRF, ZCYTO7
  • Links
    NCBI Gene ID: 27190
    neXtProt AC: NX_Q9UHF5
    UniProt: Q9UHF5

  • Chr Location
    5q32; chr5:149374267-149404202 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased susceptibility to DDS-induced colitis and Citrobacter rodentium infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56069 NCBI Gene Model | MGI Sequence Detail 4604 C57BL/6J ±  kb
transcript NM_019508 RefSeq | MGI Sequence Detail 692 Not Specified  
polypeptide Q9QXT6 UniProt | EBI | MGI Sequence Detail 180 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915790, MGI:1922686
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:62901 Shi Y, et al., A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J Biol Chem. 2000 Jun 23;275(25):19167-76
  • Latest
    J:229778 Reynolds JM, et al., Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation. Immunity. 2015 Apr 21;42(4):692-703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory