About   Help   FAQ
Pdcd10 Gene Detail
Summary
  • Symbol
    Pdcd10
  • Name
    programmed cell death 10
  • Synonyms
    2410003B13Rik, CCM3, TF-1 cell apoptosis related protein-15, Tfa15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928396
    NCBI Gene: 56426
  • Gene Overview
    MyGene.info: PDCD10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:75516490-75556856 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40367 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 33.76 cM, cytoband E3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PDCD10, programmed cell death 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDCD10, programmed cell death 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCM3, TFAR15
  • Links
    NCBI Gene ID: 11235
    neXtProt AC: NX_Q9BUL8
    UniProt: Q9BUL8

  • Chr Location
    3q26.1; chr3:167683891-167735690 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10505
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PDCD10
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Pdcd10 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 10 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal due to impaired hematopoeisis, vasculogenesis, and abnormal heart morphology. Conditional knockout in myeloids increases degranulation of, and exocytosis by, neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031048 VEGA Gene Model | MGI Sequence Detail 40367 C57BL/6J ±  kb
    transcript OTTMUST00000076917 VEGA | MGI Sequence Detail 1927 Not Applicable  
    polypeptide OTTMUSP00000040555 VEGA | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      231 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1913767
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:242287 Nishimura S, et al., Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5503-5508

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory