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Pdcd10
Gene Detail
Symbol

Name
ID
Pdcd10
programmed cell death 10
MGI:1928396
Synonyms
2410003B13Rik, CCM3, TF-1 cell apoptosis related protein-15, Tfa15
Feature Type
protein coding gene
Genetic Map
Chromosome 3
33.76 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:75516490-75556856 bp, - strand
From VEGA annotation of GRCm38

  40367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10505  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDCD10
Gene Tree: Pdcd10

Human
homologs
PDCD10, programmed cell death 10
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11235
neXtProt AC: NX_Q9BUL8

Human Synonyms: CCM3, TFAR15

Human Chr (Location): 3q26.1; chr3:167683735-167735422 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PDCD10

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality due to impaired hematopoeisis, vasculogenesis, and abnormal heart morphology.
 
Human Diseases Modeled in Mice Using Pdcd10 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Pdcd10 interacts with 265 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process angiogenesis, apoptotic process, ...
Component cytoplasm, cytosol, ...
Function protein binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (71)    Tissues (56)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 71
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdcd10 ; ZFIN pdcd10a, pdcd10b    NEW 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000031048 (Evidence)
Ensembl Gene Model ENSMUSG00000027835 (Evidence)
Entrez Gene 56426 (Evidence)
NIA Mouse Gene Index U023557, U024163
Consensus CDS Project CCDS17414.1
International Mouse Phenotyping Consortium Status Pdcd10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031048 VEGA Gene Model | MGI Sequence Detail 40367 C57BL/6J ±  kb
transcript OTTMUST00000076917 VEGA | MGI Sequence Detail 1927 Not Applicable 
polypeptide OTTMUSP00000040555 VEGA | MGI Sequence Detail 212 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(233 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009652 Protein of unknown function DUF1241
Protein Ontology PR:000012451 programmed cell death protein 10
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208651 Louvi A, et al., Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development. 2014 Mar;141(6):1404-15
All references(36)
Disease annotation references (2)
Other
accession IDs
MGI:1913767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory