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B4galt6 Gene Detail
Summary
  • Symbol
    B4galt6
  • Name
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928380
    NCBI Gene: 56386
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:20684599-20746404 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 11.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928380
protein coding gene Chr18:20684599-20746404 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024183
protein coding gene Chr18:18263322-18324987 (-)
A/J MGP_AJ_G0024147
protein coding gene Chr18:17808053-17870351 (-)
AKR/J MGP_AKRJ_G0024116
protein coding gene Chr18:18342044-18409145 (-)
BALB/cJ MGP_BALBcJ_G0024147
protein coding gene Chr18:17821197-17884977 (-)
C3H/HeJ MGP_C3HHeJ_G0023915
protein coding gene Chr18:18266068-18340591 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024589
protein coding gene Chr18:19150396-19213433 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022031
protein coding gene Chr18:16906676-16968582 (-)
CAST/EiJ MGP_CASTEiJ_G0023388
protein coding gene Chr18:18057079-18123446 (-)
CBA/J MGP_CBAJ_G0023883
protein coding gene Chr18:19623088-19689601 (-)
DBA/2J MGP_DBA2J_G0024015
protein coding gene Chr18:17519163-17582428 (-)
FVB/NJ MGP_FVBNJ_G0023981
protein coding gene Chr18:17296709-17359454 (-)
LP/J MGP_LPJ_G0024096
protein coding gene Chr18:18411702-18482936 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024009
protein coding gene Chr18:20542224-20606622 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024637
protein coding gene Chr18:18094584-18159576 (-)
PWK/PhJ MGP_PWKPhJ_G0023133
protein coding gene Chr18:17615552-17679184 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022942
protein coding gene Chr18:18312701-18378365 (-)
WSB/EiJ MGP_WSBEiJ_G0023453
protein coding gene Chr18:18019840-18083594 (-)



Homology
more
  • Human Ortholog
    B4GALT6, beta-1,4-galactosyltransferase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    B4GALT6, beta-1,4-galactosyltransferase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B4Gal-T6, beta4Gal-T6
  • Links
    NCBI Gene ID: 9331
    neXtProt AC: NX_Q9UBX8
    UniProt: Q9UBX8

  • Chr Location
    18q12.1; chr18:31622246-31724670 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype with reduced lactosylceramide synthase in MEFs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56386 NCBI Gene Model | MGI Sequence Detail 61806 C57BL/6J ±  kb
transcript NM_019737 RefSeq | MGI Sequence Detail 5808 C57BL/6  
polypeptide Q9WVK5 UniProt | EBI | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2147179, MGI:2147314
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:47946 Nomura T, et al., Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. J Biol Chem. 1998 May 29;273(22):13570-7
  • Latest
    J:227742 Mayo L, et al., Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct;20(10):1147-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory