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Dhodh Gene Detail
Summary
  • Symbol
    Dhodh
  • Name
    dihydroorotate dehydrogenase
  • Synonyms
    2810417D19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928378
    NCBI Gene: 56749
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:109591343-109608673 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17331 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.12 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DHODH, dihydroorotate dehydrogenase (quinone)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DHODH, dihydroorotate dehydrogenase (quinone)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHOdehase, POADS, URA1
  • Links
    NCBI Gene ID: 1723
    neXtProt AC: NX_Q02127
    UniProt: Q02127

  • Chr Location
    16q22.2; chr16:72008744-72027659 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032870 VEGA Gene Model | MGI Sequence Detail 17331 C57BL/6J ±  kb
    transcript OTTMUST00000081909 VEGA | MGI Sequence Detail 2039 Not Applicable  
    polypeptide OTTMUSP00000043874 VEGA | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      115 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 51
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922677, MGI:2142618
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory