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Dhodh
Gene Detail
Symbol

Name
ID
Dhodh
dihydroorotate dehydrogenase
MGI:1928378
Synonyms
2810417D19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:109591343-109608673 bp, - strand
From VEGA annotation of GRCm38

  17331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1043  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DHODH
Protein SuperFamily: DHO_oxidase
Gene Tree: Dhodh

Human
homologs
DHODH, dihydroorotate dehydrogenase (quinone)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1723
neXtProt AC: NX_Q02127

Human Synonyms: DHOdehase, POADS, URA1

Human Chr (Location): 16q22; chr16:72008744-72025417 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DHODH

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from CvDC )
Interactions
Dhodh interacts with 274 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (106)    Tissues (102)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dhodh ; ZFIN dhodh    NEW 
Molecular
reagents
All nucleic(54) Genomic(1) cDNA(51) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000032870 (Evidence)
Ensembl Gene Model ENSMUSG00000031730 (Evidence)
Entrez Gene 56749 (Evidence)
UniGene 23894
DFCI TC1578747, TC1683292
DoTS DT.101187532, DT.488024, DT.55280949, DT.97408558
NIA Mouse Gene Index U030233
EC 1.3.5.2
Consensus CDS Project CCDS40471.1
International Mouse Phenotyping Consortium Status Dhodh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032870 VEGA Gene Model | MGI Sequence Detail 17331 C57BL/6J ±  kb
transcript OTTMUST00000081909 VEGA | MGI Sequence Detail 2039 Not Applicable 
polypeptide OTTMUSP00000043874 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(3) UniProt(7)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
InterPro IPR005719 Dihydroorotate dehydrogenase, class 2
InterPro IPR001295 Dihydroorotate dehydrogenase, conserved site
InterPro IPR005720 Dihydroorotate dehydrogenase domain
Protein Ontology PR:000006460 dihydroorotate dehydrogenase (quinone), mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187427 Rainger J, et al., Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. Hum Mol Genet. 2012 Sep 15;21(18):3969-83
All references(40)
Other
accession IDs
MGI:1922677, MGI:2142618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory