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Dhodh Gene Detail
Summary
  • Symbol
    Dhodh
  • Name
    dihydroorotate dehydrogenase
  • Synonyms
    2810417D19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928378
    NCBI Gene: 56749
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110319876-110335330 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928378
 protein coding gene Chr8:110317975-110335330 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034109
 protein coding gene Chr8:112193345-112213673 (-)
A/J MGP_AJ_G0034089
 protein coding gene Chr8:107634579-107653318 (-)
AKR/J MGP_AKRJ_G0034015
 protein coding gene Chr8:110802823-110822040 (-)
BALB/cJ MGP_BALBcJ_G0034082
 protein coding gene Chr8:107856435-107873765 (-)
C3H/HeJ MGP_C3HHeJ_G0033794
 protein coding gene Chr8:111511379-111528609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034602
 protein coding gene Chr8:116160817-116180040 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031544
 protein coding gene Chr8:100684766-100700375 (-)
CAST/EiJ MGP_CASTEiJ_G0033121
 protein coding gene Chr8:111108983-111125688 (-)
CBA/J MGP_CBAJ_G0033767
 protein coding gene Chr8:120057744-120074999 (-)
DBA/2J MGP_DBA2J_G0033922
 protein coding gene Chr8:106976657-106993909 (-)
FVB/NJ MGP_FVBNJ_G0033867
 protein coding gene Chr8:105923491-105940672 (-)
LP/J MGP_LPJ_G0034013
 protein coding gene Chr8:112369612-112388264 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033912
 protein coding gene Chr8:123079092-123096628 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034621
 protein coding gene Chr8:110764349-110782494 (-)
PWK/PhJ MGP_PWKPhJ_G0032823
 protein coding gene Chr8:106537277-106554498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032662
 protein coding gene Chr8:109447606-109464654 (-)
WSB/EiJ MGP_WSBEiJ_G0033236
 protein coding gene Chr8:111448168-111466299 (-)



Homology
more
  • Human Ortholog
    DHODH, dihydroorotate dehydrogenase (quinone)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHODH, dihydroorotate dehydrogenase (quinone)
  • Synonyms
    DHOdehase, POADS, URA1
  • Links
    NCBI Gene ID: 1723
    neXtProt AC: NX_Q02127
    UniProt: Q02127

  • Chr Location
    16q22.2; chr16:72008588-72027664 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DHODH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormalities in trophoblast layer formation and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    103
  • cDNA Data
    51
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56749 NCBI Gene Model | MGI Sequence Detail 15455 C57BL/6J ±  kb
transcript NM_020046 RefSeq | MGI Sequence Detail 2318 Not Specified  
polypeptide O35435 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    Genomic 1
    cDNA 52
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:1922677, MGI:2142618
References
more
  • Summaries
    All 53
    Developmental Gene Expression 4
    Gene Ontology 14
    Phenotypes 14
  • Earliest
    J:307217 Loffler M, On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency. Eur J Biochem. 1980;107(1):207-15
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory