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Dhodh
Gene Detail
 Symbol
Name
ID
Dhodh
dihydroorotate dehydrogenase
MGI:1928378
Synonyms 2810417D19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
57.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:109591343-109608673 bp, - strand
From VEGA annotation of GRCm38

  17331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1043  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DHO_oxidase
Gene Tree: Dhodh

Human
homologs
Human Homolog DHODH, dihydroorotate dehydrogenase (quinone)
NCBI Gene ID 1723
neXtProt AC  NX_Q02127
Human Synonyms  DHOdehase, POADS, URA1
Human Chr (Location)  16q22; chr16:72008744-72025417 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DHODH
Alleles
and
phenotypes
All alleles(13) : Targeted(4) Gene trapped(9)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process 'de novo' pyrimidine nucleobase biosynthetic process, oxidation-reduction process, ...
Component integral component of membrane, membrane, ...
Function catalytic activity, dihydroorotate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (106)    Tissues (102)    Images (5)
Theiler Stages: 17, 22
Assay TypeResults
RNA in situ 106
cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) Genomic(1) cDNA(51) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000032870 (Evidence)
Ensembl Gene ModelENSMUSG00000031730 (Evidence)
Entrez Gene56749 (Evidence)
UniGene23894
DFCITC1578747, TC1683292
DoTSDT.101187532, DT.488024, DT.55280949, DT.97408558
NIA Mouse Gene IndexU030233
EC1.3.5.2
Consensus CDS ProjectCCDS40471.1
International Mouse Knockout Project StatusDhodh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032870 VEGA Gene Model | MGI Sequence Detail 17331 C57BL/6J ±  kb
transcript OTTMUST00000081909 VEGA | MGI Sequence Detail 2039 Not Applicable 
polypeptide OTTMUSP00000043874 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(3) UniProt(7)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
InterPro IPR005719 Dihydroorotate dehydrogenase, class 2
InterPro IPR001295 Dihydroorotate dehydrogenase, conserved site
Protein Ontology PR:000006460 dihydroorotate dehydrogenase (quinone), mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187427 Rainger J, et al., Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. Hum Mol Genet. 2012 Sep 15;21(18):3969-83
All references(40)
Other
accession IDs
MGI:1922677, MGI:2142618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory