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Elf4
Gene Detail
 Symbol
Name
ID
Elf4
E74-like factor 4 (ets domain transcription factor)
MGI:1928377
Synonyms MEF, myeloid elf-1 like factor
Feature Type protein coding gene
Genetic Map
Chromosome X
25.67 cM, cytoband A3.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:48411046-48463132 bp, - strand
From VEGA annotation of GRCm38

  52087 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31036  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Elf4

Human
homologs
Human Homolog ELF4, E74-like factor 4 (ets domain transcription factor)
NCBI Gene ID 2000
neXtProt AC  NX_Q99607
Human Synonyms  ELFR, MEF
Human Chr (Location)  Xq26; chrX:130064920-130110713 (-)  GRCh38
Alleles
and
phenotypes
All alleles(16) : Gene trapped(12) Targeted(4)
 
Mice homozygous for disruptions in this gene have hematopoietic cells with impaired proliferative properties. Lymphocyte development and function is altered, particularly with respect to NK cells and NK-T cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell differentiation, natural killer cell proliferation, ...
Component nucleus, PML body
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (252)    Tissues (155)    Images (47)
Theiler Stages: 17, 18, 21, 22, 23, 28
Assay TypeResults
RNA in situ 252
cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017543 (Evidence)
Ensembl Gene ModelENSMUSG00000031103 (Evidence)
Entrez Gene56501 (Evidence)
UniGene36808
DFCITC1588686, TC1600301
DoTSDT.111036243, DT.40143233
NIA Mouse Gene IndexU039354
Consensus CDS ProjectCCDS30108.1
International Mouse Knockout Project StatusElf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017543 VEGA Gene Model | MGI Sequence Detail 52087 C57BL/6J ±  kb
transcript OTTMUST00000042635 VEGA | MGI Sequence Detail 6088 Not Applicable 
polypeptide OTTMUSP00000019159 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR022084 Transcription factor Elf, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007023 ETS-related transcription factor Elf-4
References (Earliest) J:79568 Lacorazza HD, et al., The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer and NK-T Cells. Immunity. 2002 Oct;17(4):437
(Latest) J:209289 Mamonkin M, et al., Transcription factor ELF4 promotes development and function of memory CD8(+) T cells in Listeria monocytogenes infection. Eur J Immunol. 2014 Mar;44(3):715-27
All references(59)
Other
accession IDs
MGI:2147984, MGI:2671002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory