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Elf4 Gene Detail
Summary
  • Symbol
    Elf4
  • Name
    E74 like ETS transcription factor 4
  • Synonyms
    MEF, myeloid elf-1 like factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928377
    NCBI Gene: 56501
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:47499926-47552009 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 25.67 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    826 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928377
 protein coding gene ChrX:47499923-47552009 (-)
129S1/SvImJ ENSMUSG00200037465
 protein coding gene ChrX:31531064-31583209 (-)
A/J ENSMUSG00195016851
 protein coding gene ChrX:34132702-34184859 (-)
AKR/J ENSMUSG00220035129
 protein coding gene ChrX:31021137-31073277 (-)
BALB/cJ ENSMUSG00180031217
 protein coding gene ChrX:31862606-31914756 (-)
C3H/HeJ ENSMUSG00175038928
 protein coding gene ChrX:34881251-34933390 (-)
C57BL/6NJ ENSMUSG00215046422
 protein coding gene ChrX:31874783-31926876 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033042
 protein coding gene ChrX:41120889-41172913 (-)
CAST/EiJ ENSTCUG00005035965
 protein coding gene ChrX:33955490-34007684 (-)
CBA/J ENSMUSG00210035421
 protein coding gene ChrX:32124778-32176917 (-)
DBA/2J ENSMUSG00185032684
 protein coding gene ChrX:42831163-42883304 (-)
FVB/NJ ENSMUSG00205028157
 protein coding gene ChrX:30810438-30862581 (-)
JF1/MsJ ENSUMUG00000021643
 protein coding gene ChrX:61884537-61937233 (-)
LP/J ENSMUSG00230018825
 protein coding gene ChrX:49363498-49415642 (-)
NOD/ShiLtJ ENSMUSG00190027639
 protein coding gene ChrX:31300400-31352550 (-)
NZO/HlLtJ ENSMUSG00225042127
 protein coding gene ChrX:54557257-54609342 (-)
PWK/PhJ ENSLUMG00010037428
 protein coding gene ChrX:31602212-31654717 (-)
SPRET/EiJ ENSMSPG00010023398
 protein coding gene ChrX:33186115-33199316 (-)
WSB/EiJ ENSIUOG00005044055
 protein coding gene ChrX:32411006-32463111 (-)



Homology
more
  • Human Ortholog
    ELF4, E74 like ETS transcription factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELF4, E74 like ETS transcription factor 4
  • Synonyms
    AIFBL2, ELFR, MEF
  • Links
    NCBI Gene ID: 2000
    UniProt: Q99607

  • Chr Location
    Xq26.1; chrX:130063955-130111858 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have hematopoietic cells with impaired proliferative properties. Lymphocyte development and function is altered, particularly with respect to NK cells and NK-T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    868
  • Tissues
    171
  • cDNA Data
    30
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56501 NCBI Gene Model | MGI Sequence Detail 52084 C57BL/6J ±  kb
transcript NM_001381876 RefSeq | MGI Sequence Detail 6234 C57BL/6  
polypeptide Q9Z2U4 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 31
    Primer pair 2
    Other 1
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147984, MGI:2671002
References
more
  • Summaries
    All 86
    Developmental Gene Expression 12
    Gene Ontology 10
    Phenotypes 29
  • Earliest
    J:113799 Mao S, et al., Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. Mol Cell Biol. 1999 May;19(5):3635-44
  • Latest
    J:361454 Jasmine, et al., Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns. Dev Biol. 2025 Jan 9;520:155-170
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory