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Ptpn9 Gene Detail
Summary
  • Symbol
    Ptpn9
  • Name
    protein tyrosine phosphatase, non-receptor type 9
  • Synonyms
    Meg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928376
    NCBI Gene: 56294
  • Gene Overview
    MyGene.info: PTPN9
Location & Maps
more
  • Sequence Map
    Chr9:56994968-57062805 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67838 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.70 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PTPN9, protein tyrosine phosphatase, non-receptor type 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPN9, protein tyrosine phosphatase, non-receptor type 9
    Orthology source: HomoloGene
  • Synonyms
    MEG2, PTPMEG2
  • Links
    NCBI Gene ID: 5780
    neXtProt AC: NX_P43378

  • Chr Location
    15q24.2; chr15:75467121-75579291 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display hemorrhages, craniofacial anomalies, neural tube defects such as exencephaly and meningomyeloceles, cerebral infarctions, abnormal bone development, and >90% late embryonic lethality in addition to severe defectsin T lymphocyte and platelet activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032290 Ensembl Gene Model | MGI Sequence Detail 67838 C57BL/6J ±  kb
transcript ENSMUST00000034832 Ensembl | MGI Sequence Detail 4054 Not Applicable  
polypeptide ENSMUSP00000034832 Ensembl | MGI Sequence Detail 593 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    121 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013463 tyrosine-protein phosphatase non-receptor type 9
  • EC
  • InterPro Domains
    IPR001251 CRAL-TRIO lipid binding domain
    IPR011074 CRAL/TRIO, N-terminal domain
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 24
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory