Ptpn9 MGI Mouse Gene Detail - MGI:1928376 - protein tyrosine phosphatase, non-receptor type 9

Symbol

Ptpn9
Name

protein tyrosine phosphatase, non-receptor type 9
Synonyms

Meg2

Feature Type

protein coding gene
IDs

MGI:1928376
NCBI Gene: 56294
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:56902252-56970092 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 30.70 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

1452 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928376	protein coding gene	Chr9:56902207-56970092 (+)
129S1/SvImJ	ENSMUSG00200035604	protein coding gene	Chr9:54016569-54084380 (+)
A/J	ENSMUSG00195035541	protein coding gene	Chr9:53715279-53783165 (+)
AKR/J	ENSMUSG00220024484	protein coding gene	Chr9:53852520-53920411 (+)
BALB/cJ	ENSMUSG00180018348	protein coding gene	Chr9:53841297-53909179 (+)
C3H/HeJ	ENSMUSG00175020862	protein coding gene	Chr9:53842101-53909974 (+)
C57BL/6NJ	ENSMUSG00215012322	protein coding gene	Chr9:53834664-53902542 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032260	protein coding gene	Chr9:53685791-53756069 (+)
CAST/EiJ	ENSTCUG00005018947	protein coding gene	Chr9:53740181-53811045 (+)
CBA/J	ENSMUSG00210032591	protein coding gene	Chr9:53943744-54011700 (+)
DBA/2J	ENSMUSG00185039990	protein coding gene	Chr9:53972481-54040313 (+)
FVB/NJ	ENSMUSG00205021023	protein coding gene	Chr9:54285234-54353110 (+)
JF1/MsJ	ENSUMUG00000032839	protein coding gene	Chr9:53992557-54062905 (+)
LP/J	ENSMUSG00230033828	protein coding gene	Chr9:54216360-54284170 (+)
NOD/ShiLtJ	ENSMUSG00190034460	protein coding gene	Chr9:54040516-54108390 (+)
NZO/HlLtJ	ENSMUSG00225028073	protein coding gene	Chr9:54253698-54321569 (+)
PWK/PhJ	ENSLUMG00010033837	protein coding gene	Chr9:53954933-54025282 (+)
SPRET/EiJ	ENSMSPG00010026734	protein coding gene	Chr9:54984508-55054041 (+)
WSB/EiJ	ENSIUOG00005032512	protein coding gene	Chr9:53454489-53522372 (+)

Human Ortholog

PTPN9, protein tyrosine phosphatase non-receptor type 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN9, protein tyrosine phosphatase non-receptor type 9
Synonyms

MEG2, PTPMEG2
Links

HGNC:9661

NCBI Gene ID: 5780

UniProt: P43378
Chr Location

15q24.2; chr15:75463251-75579583 (-) GRCh38

MGI Vertebrate Homology

Ptpn9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTPN9
Gene Tree

Ptpn9

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Phenotype Summary

24 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display hemorrhages, craniofacial anomalies, neural tube defects such as exencephaly and meningomyeloceles, cerebral infarctions, abnormal bone development, and >90% late embryonic lethality in addition to severe defectsin T lymphocyte and platelet activation.

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All GO Annotations

19
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

643
Tissues

19
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn9, ptpn9l

ZFIN ptpn9a, ptpn9b

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All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS23215.1

Ensembl

ENSMUSG00000032290 (Evidence)
NCBI Gene

56294

			Length	Strain/Species	Flank
genomic	56294	NCBI Gene Model \| MGI Sequence Detail	67841	C57BL/6J	± kb
transcript	NM_019651	RefSeq \| MGI Sequence Detail	4087	C57BL/6
polypeptide	O35239	UniProt \| EBI \| MGI Sequence Detail	593	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013463 tyrosine-protein phosphatase non-receptor type 9

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR036273 CRAL/TRIO, N-terminal domain superfamily

IPR050348 Protein-Tyrosine Phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 9

cDNA 8

Primer pair 1

Antibodies 2

Microarray probesets 6

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ptpn9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85273	Chr9:56901849-56901892 (+)	-381 bp
Tssr85274	Chr9:56902147-56902158 (+)	-99 bp
Tssr85275	Chr9:56902173-56902202 (+)	-64 bp
Tssr85276	Chr9:56902216-56902270 (+)	-9 bp
Tssr85277	Chr9:56902361-56902401 (+)	129 bp
Tssr85278	Chr9:56902410-56902423 (+)	165 bp
Tssr85279	Chr9:56902662-56902748 (+)	453 bp
Tssr85280	Chr9:56902838-56902860 (+)	597 bp
Tssr85281	Chr9:56904810-56904814 (+)	2,560 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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