Arpc3 MGI Mouse Gene Detail - MGI:1928375 - actin related protein 2/3 complex, subunit 3

Symbol

Arpc3
Name

actin related protein 2/3 complex, subunit 3
Synonyms

1110006A04Rik, Arp2/3 complex subunit p21-Arc, p21-Ar

Feature Type

protein coding gene
IDs

MGI:1928375
NCBI Gene: 56378
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:122529941-122544244 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.34 cM
Mapping Data

2 experiments

SNPs within 2kb

509 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928375	protein coding gene	Chr5:122529941-122552247 (+)
129S1/SvImJ	ENSMUSG00200026699	protein coding gene	Chr5:116255825-116278141 (+)
A/J	ENSMUSG00195010663	protein coding gene	Chr5:115777169-115799483 (+)
AKR/J	ENSMUSG00220039215	protein coding gene	Chr5:115291427-115313737 (+)
BALB/cJ	ENSMUSG00180032735	protein coding gene	Chr5:115891700-115914020 (+)
C3H/HeJ	ENSMUSG00175021530	protein coding gene	Chr5:117911346-117933651 (+)
C57BL/6NJ	ENSMUSG00215042473	protein coding gene	Chr5:115937156-115959466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027706	protein coding gene	Chr5:115412189-115435333 (+)
CAST/EiJ	ENSTCUG00005036316	protein coding gene	Chr5:115185912-115208326 (+)
CBA/J	ENSMUSG00210006707	protein coding gene	Chr5:116662171-116684480 (+)
DBA/2J	ENSMUSG00185051749	protein coding gene	Chr5:119713385-119735692 (+)
FVB/NJ	ENSMUSG00205018078	protein coding gene	Chr5:115566989-115589299 (+)
JF1/MsJ	ENSUMUG00000024809	protein coding gene	Chr5:122554774-122577318 (+)
LP/J	ENSMUSG00230038100	protein coding gene	Chr5:123777868-123800183 (+)
NOD/ShiLtJ	ENSMUSG00190033799	protein coding gene	Chr5:115588696-115611241 (+)
NZO/HlLtJ	ENSMUSG00225013828	protein coding gene	Chr5:131470207-131492514 (+)
PWK/PhJ	ENSLUMG00010033746	protein coding gene	Chr5:114463636-114486250 (+)
SPRET/EiJ	ENSMSPG00010039873	protein coding gene	Chr5:117775334-117798339 (+)
WSB/EiJ	ENSIUOG00005018925	protein coding gene	Chr5:118277569-118300095 (+)

Human Ortholog

ARPC3, actin related protein 2/3 complex subunit 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARPC3, actin related protein 2/3 complex subunit 3
Synonyms

ARC21, p21-Arc
Links

HGNC:706

NCBI Gene ID: 10094

UniProt: O15145
Chr Location

12q24.11; chr12:110434582-110450422 (-) GRCh38

MGI Vertebrate Homology

Arpc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARPC3
Protein SuperFamily

ARP2/3_P21-Arc
Gene Tree

Arpc3

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Phenotype Summary

23 phenotypes from 5 alleles in 7 genetic backgrounds
1 phenotype from multigenic genotypes
2 images
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

5
Radiation induced

1
Targeted

4
Transposon induced

1
Genomic Mutations

2 involving Arpc3
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transposon-induced allele develop only to the blastocyst stage and show defects in trophoblast outgrowth and in the dynamics of actin accumulation. Mice heterozygous for the same transposon-induced allele and a knock-out allele showimpaired trophoblast outgrowth activity.

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All GO Annotations

31
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

2
cDNA Data

150
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arpc3

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All Sequences

57
RefSeq

2
UniProt

5
CCDS

CCDS19648.1

Ensembl

ENSMUSG00000029465 (Evidence)
NCBI Gene

56378

			Length	Strain/Species	Flank
genomic	56378	NCBI Gene Model \| MGI Sequence Detail	14304	C57BL/6J	± kb
transcript	NM_019824	RefSeq \| MGI Sequence Detail	918	C57BL/6
polypeptide	Q9JM76	UniProt \| EBI \| MGI Sequence Detail	178	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004311 actin-related protein 2/3 complex subunit 3

(term hierarchy)
PDB

7AQK
InterPro Domains

IPR007204 Actin-related protein 2/3 complex subunit 3

IPR036753 Actin-related protein 2/3 complex subunit 3 superfamily
GlyGen

Q9JM76 1 site, 1 O-linked glycan (1 site)

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All nucleic 151

cDNA 150

Primer pair 1

Microarray probesets 3

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MGI:1913400, MGI:2140738, MGI:2140961

Summaries

All 68

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 28
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:352813 Chioccioli M, et al., Stem cell migration drives lung repair in living mice. Correction. Dev Cell. 2024 Feb 14;

TSS for Arpc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48682	Chr5:122529953-122529991 (+)	31 bp
Tssr48683	Chr5:122530005-122530021 (+)	72 bp
Tssr48684	Chr5:122530022-122530023 (+)	82 bp
Tssr48685	Chr5:122530333-122530337 (+)	394 bp
Tssr48686	Chr5:122534810-122534816 (+)	4,872 bp
Tssr48687	Chr5:122534901-122534958 (+)	4,989 bp
Tssr48688	Chr5:122539692-122539713 (+)	9,762 bp
Tssr48689	Chr5:122541419-122541467 (+)	11,502 bp
Tssr48690	Chr5:122542203-122542258 (+)	12,290 bp
Tssr48691	Chr5:122544137-122544178 (+)	14,217 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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