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Arpc3
Gene Detail
 Symbol
Name
ID
Arpc3
actin related protein 2/3 complex, subunit 3
MGI:1928375
Synonyms 1110006A04Rik, Arp2/3 complex subunit p21-Arc, p21-Ar
Feature Type protein coding gene
Genetic Map
Chromosome 5
62.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122391878-122406179 bp, + strand
From VEGA annotation of GRCm38

  14302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4178  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: actin-related protein 2/3 complex, subunit 3
Gene Tree: Arpc3

Human
homologs
Human Homolog ARPC3, actin related protein 2/3 complex, subunit 3, 21kDa
NCBI Gene ID 10094
neXtProt AC  NX_O15145
Human Synonyms  ARC21, p21-Arc
Human Chr (Location)  12q24.11; chr12:110434890-110450411 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(4) Transposon induced(1)
 
Mice homozygous for a transposon-induced allele develop only to the blastocyst stage and show defects in trophoblast outgrowth and in the dynamics of actin accumulation. Mice heterozygous for the same transposon-induced allele and a knock-out allele show impaired trophoblast outgrowth activity.
 
Phenotype Images(2)
Interactions
Arpc3 interacts with 51 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process Arp2/3 complex-mediated actin nucleation, regulation of actin filament polymerization
Component Arp2/3 protein complex, cell projection, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 23, 27
Assay TypeResults
RT-PCR 2
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(150) cDNA(149) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016282 (Evidence)
Ensembl Gene ModelENSMUSG00000029465 (Evidence)
Entrez Gene56378 (Evidence)
UniGene275942
DFCITC1572792
DoTSDT.535643
NIA Mouse Gene IndexU006139
Consensus CDS ProjectCCDS19648.1
International Mouse Knockout Project StatusArpc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016282 VEGA Gene Model | MGI Sequence Detail 14302 C57BL/6J ±  kb
transcript OTTMUST00000039086 VEGA | MGI Sequence Detail 899 Not Applicable 
polypeptide OTTMUSP00000017455 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007204 ARP2/3 complex, 21kDa subunit (p21-Arc)
Protein Ontology PR:000004311 actin-related protein 2/3 complex subunit 3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201137 Zhou K, et al., Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-E3829
All references(43)
Other
accession IDs
MGI:1913400, MGI:2140738, MGI:2140961

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory