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Dnajc7 Gene Detail
Summary
  • Symbol
    Dnajc7
  • Name
    DnaJ heat shock protein family (Hsp40) member C7
  • Synonyms
    2010003F24Rik, 2010004G07Rik, mDj11, mTpr2, Ttc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928373
    NCBI Gene: 56354
  • Gene Overview
    MyGene.info: DNAJC7
Location & Maps
more
  • Sequence Map
    Chr11:100582818-100620168 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37351 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    DNAJC7, DnaJ heat shock protein family (Hsp40) member C7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    DNAJC7, DnaJ heat shock protein family (Hsp40) member C7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DJ11, DJC7, TPR2, TTC2
  • Links
    NCBI Gene ID: 7266
    neXtProt AC: NX_Q99615

  • Chr Location
    17q21.2; chr17:41974005-42021371 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68306
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DNAJC7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    226
  • Gene trapped
    220
  • Targeted
    6
  • Genomic Mutations
    1 involving Dnajc7
  • Incidental Mutations
    APF
Male mice homozygous for a knock-out allele exhibit hepatic steatosis and increased serum cholesterol.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002027 VEGA Gene Model | MGI Sequence Detail 37351 C57BL/6J ±  kb
transcript OTTMUST00000004113 VEGA | MGI Sequence Detail 2330 Not Applicable  
polypeptide OTTMUSP00000001976 VEGA | MGI Sequence Detail 494 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    240 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 166
    cDNA 166

    Microarray probesets 3
Other
Accession IDs
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MGI:1913794, MGI:1914883
References
more
  • Summaries
    All 42
    Gene Ontology 2
    Phenotypes 19
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:225381 Ohno M, et al., The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. PLoS One. 2014;9(12):e115663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory