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Rhog Gene Detail
Summary
  • Symbol
    Rhog
  • Name
    ras homolog family member G
  • Synonyms
    2810426G09Rik, Arhg, RhoG, Sid10750
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928370
    NCBI Gene: 56212
  • Gene Overview
    MyGene.info: RHOG
Location & Maps
more
  • Sequence Map
    Chr7:102239123-102250123 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11001 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RHOG, ras homolog family member G
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RHOG, ras homolog family member G
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHG
  • Links
    NCBI Gene ID: 391
    neXtProt AC: NX_P84095

  • Chr Location
    11p15.5-p15.4; chr11:3826978-3840983 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Rhog
Mice homozygous for disruptions in this gene display and essentially normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022529 VEGA Gene Model | MGI Sequence Detail 11001 C57BL/6J ±  kb
transcript OTTMUST00000053958 VEGA | MGI Sequence Detail 1269 Not Applicable  
polypeptide OTTMUSP00000025699 VEGA | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    189 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013981 rho-related GTP-binding protein RhoG
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 58
    cDNA 58

    Microarray probesets 3
Other
Accession IDs
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MGI:1920001
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 23
  • Earliest
    J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
  • Latest
    J:214692 Damoulakis G, et al., P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. J Cell Sci. 2014 Jun 1;127(Pt 11):2589-600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory