Creg2 MGI Mouse Gene Detail - MGI:1928333 - cellular repressor of E1A-stimulated genes 2

Symbol

Creg2
Name

cellular repressor of E1A-stimulated genes 2
Synonyms

A830098L22Rik

Feature Type

protein coding gene
IDs

MGI:1928333
NCBI Gene: 263764
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:39657574-39690350 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 18.37 cM
Mapping Data

1 experiment

SNPs within 2kb

308 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928333	protein coding gene	Chr1:39657574-39690642 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015960	protein coding gene	Chr1:38374437-38408622 (-)
A/J	MGP_AJ_G0015944	protein coding gene	Chr1:37296982-37330254 (-)
AKR/J	MGP_AKRJ_G0015899	protein coding gene	Chr1:37800046-37833000 (-)
BALB/cJ	MGP_BALBcJ_G0015898	protein coding gene	Chr1:36943268-36976662 (-)
C3H/HeJ	MGP_C3HHeJ_G0015731	protein coding gene	Chr1:38060883-38094272 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016351	protein coding gene	Chr1:39967161-40001593 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014073	protein coding gene	Chr1:34258521-34289512 (-)
CAST/EiJ	MGP_CASTEiJ_G0015312	protein coding gene	Chr1:37947466-37987811 (-)
CBA/J	MGP_CBAJ_G0015703	protein coding gene	Chr1:41121404-41162025 (-)
DBA/2J	MGP_DBA2J_G0015804	protein coding gene	Chr1:36579715-36613454 (-)
FVB/NJ	MGP_FVBNJ_G0015806	protein coding gene	Chr1:36114952-36148160 (-)
LP/J	MGP_LPJ_G0015874	protein coding gene	Chr1:38708789-38744848 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015826	protein coding gene	Chr1:43168354-43202342 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016398	protein coding gene	Chr1:37924383-37958310 (-)
PWK/PhJ	MGP_PWKPhJ_G0015095	protein coding gene	Chr1:36400323-36434229 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014877	protein coding gene	Chr1:37857185-37889923 (-)
WSB/EiJ	MGP_WSBEiJ_G0015374	protein coding gene	Chr1:37874770-37908849 (-)

Human Ortholog

CREG2, cellular repressor of E1A stimulated genes 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CREG2, cellular repressor of E1A stimulated genes 2
Links

HGNC:14272

NCBI Gene ID: 200407

neXtProt AC: NX_Q8IUH2

UniProt: Q8IUH2
Chr Location

2q11.2; chr2:101348354-101387970 (-) GRCh38.p7

Alliance of Genome Resources

Creg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CREG2
Protein SuperFamily

CREG
Gene Tree

Creg2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Creg2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

692
Tissues

7
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN creg2

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Creg2 interacts with 362 markers (Mir1a-1, Mir1a-2, Mir7-2, ...) View All

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS14908.1

Ensembl

ENSMUSG00000050967 (Evidence)
NCBI Gene

263764

			Length	Strain/Species	Flank
genomic	263764	NCBI Gene Model \| MGI Sequence Detail	32777	C57BL/6J	± kb
transcript	NM_170597	RefSeq \| MGI Sequence Detail	5799	C57BL/6
polypeptide	Q8BGC9	UniProt \| EBI \| MGI Sequence Detail	288	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005864 protein CREG2

(term hierarchy)
InterPro Domains

IPR014631 Cellular repressor of E1A-stimulated genes (CREG)

IPR012349 FMN-binding split barrel

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 3

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MGI:2442340

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:240319 Stauber M, et al., Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188

TSS for Creg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11408	Chr1:39690450-39690489 (-)	-120 bp
Tssr11407	Chr1:39690333-39690364 (-)	1 bp
Tssr11406	Chr1:39690108-39690159 (-)	216 bp
Tssr11405	Chr1:39690022-39690055 (-)	311 bp
Tssr11404	Chr1:39668618-39668624 (-)	21,729 bp
Tssr11403	Chr1:39660365-39660377 (-)	29,979 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/09/2022 MGI 6.21