About   Help   FAQ
Plekha2 Gene Detail
Summary
  • Symbol
    Plekha2
  • Name
    pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
  • Synonyms
    6430512N22Rik, TAPP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928144
    NCBI Gene: 83436
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25039144-25102376 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 13.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928144
protein coding gene Chr8:25039144-25104929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033479
protein coding gene Chr8:23036904-23105531 (-)
A/J MGP_AJ_G0033459
protein coding gene Chr8:22230992-22295716 (-)
AKR/J MGP_AKRJ_G0033384
protein coding gene Chr8:22947236-23014499 (-)
BALB/cJ MGP_BALBcJ_G0033455
protein coding gene Chr8:22375376-22438561 (-)
C3H/HeJ MGP_C3HHeJ_G0033169
protein coding gene Chr8:23165655-23234947 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033971
protein coding gene Chr8:23984681-24059033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030921
protein coding gene Chr8:19513839-19577892 (-)
CAST/EiJ MGP_CASTEiJ_G0032495
protein coding gene Chr8:22590243-22658907 (-)
CBA/J MGP_CBAJ_G0033144
protein coding gene Chr8:24901595-24979494 (-)
DBA/2J MGP_DBA2J_G0033299
protein coding gene Chr8:22201239-22267276 (-)
FVB/NJ MGP_FVBNJ_G0033243
protein coding gene Chr8:22001441-22066663 (-)
LP/J MGP_LPJ_G0033388
protein coding gene Chr8:23027830-23095341 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033286
protein coding gene Chr8:24420262-24486555 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033990
protein coding gene Chr8:22900829-22968826 (-)
PWK/PhJ MGP_PWKPhJ_G0032206
protein coding gene Chr8:21806080-21875984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032040
protein coding gene Chr8:22237569-22310483 (-)
WSB/EiJ MGP_WSBEiJ_G0032611
protein coding gene Chr8:23101697-23167494 (-)



Homology
more
  • Human Ortholog
    PLEKHA2, pleckstrin homology domain containing A2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLEKHA2, pleckstrin homology domain containing A2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TAPP2
  • Links
    NCBI Gene ID: 59339
    neXtProt AC: NX_Q9HB19
    UniProt: Q9HB19

  • Chr Location
    8p11.22; chr8:38901235-38973912 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a knock-in allele are viable.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031557 Ensembl Gene Model | MGI Sequence Detail 63233 C57BL/6J ±  kb
transcript ENSMUST00000064883 Ensembl | MGI Sequence Detail 5176 Not Applicable  
polypeptide ENSMUSP00000066546 Ensembl | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • PDB
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR024774 Pleckstrin homology domain, Mcp5-type
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923451, MGI:2142635, MGI:2142717, MGI:2142903
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:246248 Jayachandran N, et al., B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice. Eur J Immunol. 2017 Feb;47(2):280-290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/13/2019
MGI 6.13
The Jackson Laboratory