About   Help   FAQ
Mrps22 Gene Detail
Summary
  • Symbol
    Mrps22
  • Name
    mitochondrial ribosomal protein S22
  • Synonyms
    3100002P07Rik, Rpms22
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928137
    NCBI Gene: 64655
  • Gene Overview
    MyGene.info: MRPS22
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:98588730-98601660 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12931 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MRPS22, mitochondrial ribosomal protein S22
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MRPS22, mitochondrial ribosomal protein S22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3orf5, COXPD5, GIBT, GK002, MRP-S22, RPMS22
  • Links
    NCBI Gene ID: 56945
    neXtProt AC: NX_P82650
    UniProt: P82650

  • Chr Location
    3q23; chr3:139343994-139357129 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 57030
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MRPS22
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MRPS22 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047584 VEGA Gene Model | MGI Sequence Detail 12931 C57BL/6J ±  kb
transcript OTTMUST00000122720 VEGA | MGI Sequence Detail 1197 Not Applicable  
polypeptide OTTMUSP00000067229 VEGA | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    197 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 45
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1913568
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65190 Koc EC, et al., A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. J Biol Chem. 2000 Oct 20;275(42):32585-91
  • Latest
    J:261971 Chen A, et al., Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet. 2018 Jun 1;27(11):1913-1926

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/31/2018
MGI 6.12
The Jackson Laboratory