Pglyrp2 MGI Mouse Gene Detail - MGI:1928099 - peptidoglycan recognition protein 2

Symbol

Pglyrp2
Name

peptidoglycan recognition protein 2
Synonyms

C730002N09Rik, Pglyrpl, PGRP-L, tagL, tagL-alpha, tagl-beta

Feature Type

protein coding gene
IDs

MGI:1928099
NCBI Gene: 57757
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr17:32631433-32643141 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.56 cM
Mapping Data

1 experiment

SNPs within 2kb

606 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928099	protein coding gene	Chr17:32631433-32643157 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023505	protein coding gene	Chr17:32251675-32264208 (-)
A/J	MGP_AJ_G0023462	protein coding gene	Chr17:31179482-31191060 (-)
AKR/J	MGP_AKRJ_G0023428	protein coding gene	Chr17:31465293-31475854 (-)
BALB/cJ	MGP_BALBcJ_G0023467	protein coding gene	Chr17:31272598-31284202 (-)
C3H/HeJ	MGP_C3HHeJ_G0023229	protein coding gene	Chr17:31863117-31873589 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023910	protein coding gene	Chr17:33342415-33355843 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021384	protein coding gene	Chr17:28281324-28291215 (-)
CAST/EiJ	MGP_CASTEiJ_G0022730	protein coding gene	Chr17:31917338-31927831 (-)
CBA/J	MGP_CBAJ_G0023204	protein coding gene	Chr17:34805639-34821493 (-)
DBA/2J	MGP_DBA2J_G0023334	protein coding gene	Chr17:30554971-30564382 (-)
FVB/NJ	MGP_FVBNJ_G0023304	protein coding gene	Chr17:30381778-30393819 (-)
LP/J	MGP_LPJ_G0023412	protein coding gene	Chr17:32466537-32478519 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023322	protein coding gene	Chr17:33870509-33888460 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023952	protein coding gene	Chr17:31829573-31840823 (-)
PWK/PhJ	MGP_PWKPhJ_G0022479	protein coding gene	Chr17:29449711-29459164 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022298	protein coding gene	Chr17:29847453-29857820 (-)
WSB/EiJ	MGP_WSBEiJ_G0022792	protein coding gene	Chr17:31809968-31824704 (-)

Human Ortholog

PGLYRP2, peptidoglycan recognition protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PGLYRP2, peptidoglycan recognition protein 2
Synonyms

HMFT0141, PGLYRPL, PGRP-L, PGRPL, tagL, tagL-alpha, tagl-beta, TAGL-like
Links

HGNC:30013

NCBI Gene ID: 114770

UniProt: Q96PD5
Chr Location

19p13.12; chr19:15468645-15498956 (-) GRCh38

MGI Vertebrate Homology

Pglyrp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PGLYRP2
Gene Tree

Pglyrp2

less

Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis.

less

All GO Annotations

35
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

34
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pglyrp2

ZFIN pglyrp2

less

All Sequences

80
RefSeq

21
UniProt

10
CCDS

CCDS37557.1, CCDS89065.1, CCDS89066.1, CCDS89067.1

Ensembl

ENSMUSG00000079563 (Evidence)
NCBI Gene

57757

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079563	Ensembl Gene Model \| MGI Sequence Detail	11709	C57BL/6J	± kb
transcript	ENSMUST00000170392	Ensembl \| MGI Sequence Detail	1807	Not Applicable
polypeptide	ENSMUSP00000129964	Ensembl \| MGI Sequence Detail	530	Not Applicable

less

UniProt

10 Sequences
Protein Ontology

PR:000012611 N-acetylmuramoyl-L-alanine amidase

(term hierarchy)
EC

3.5.1.28
InterPro Domains

IPR002502 N-acetylmuramoyl-L-alanine amidase domain

IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily

IPR015510 Peptidoglycan recognition protein

IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
GlyGen

Q8VCS0 5 sites, 2 N-linked glycans (2 sites)

less

All nucleic 34

cDNA 34

Microarray probesets 2

less

MGI:2444214

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 14
Earliest

J:66028 Mirkina II, et al., [Cloning and study of novel mammalian genes with structural homology with phage lysozyme]. Genetika. 2000 Nov;36(11):1492-500
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Pglyrp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147391	Chr17:32644254-32644269 (-)	-1,121 bp
Tssr147390	Chr17:32643153-32643164 (-)	-18 bp
Tssr147389	Chr17:32643131-32643136 (-)	7 bp
Tssr147388	Chr17:32643113-32643127 (-)	21 bp
Tssr147387	Chr17:32643076-32643101 (-)	52 bp
Tssr147386	Chr17:32639972-32639977 (-)	3,166 bp
Tssr147385	Chr17:32639939-32639960 (-)	3,191 bp
Tssr147384	Chr17:32639891-32639922 (-)	3,234 bp
Tssr147383	Chr17:32637829-32637830 (-)	5,311 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24