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Pglyrp2 Gene Detail
Summary
  • Symbol
    Pglyrp2
  • Name
    peptidoglycan recognition protein 2
  • Synonyms
    C730002N09Rik, Pglyrpl, PGRP-L, tagL, tagL-alpha, tagl-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928099
    NCBI Gene: 57757
  • Gene Overview
    MyGene.info: PGLYRP2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr17:32413100-32424167 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      11068 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.56 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PGLYRP2, peptidoglycan recognition protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PGLYRP2, peptidoglycan recognition protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMFT0141, PGLYRPL, PGRPL, PGRP-L, tagL, tagL-alpha, tagl-beta, TAGL-like
  • Links
    NCBI Gene ID: 114770
    neXtProt AC: NX_Q96PD5
    UniProt: Q96PD5

  • Chr Location
    19p13.12; chr19:15468645-15479504 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    94
  • Tissues
    94
  • cDNA Data
    33
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079563 Ensembl Gene Model | MGI Sequence Detail 11068 C57BL/6J ±  kb
transcript ENSMUST00000170392 Ensembl | MGI Sequence Detail 2068 Not Applicable  
polypeptide ENSMUSP00000129964 Ensembl | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    25 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012611 N-acetylmuramoyl-L-alanine amidase
    (term hierarchy)
  • EC
    3.5.1.28
  • InterPro Domains
    IPR002502 N-acetylmuramoyl-L-alanine amidase domain
    IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
    IPR015510 Peptidoglycan recognition protein
    IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 2
Other
Accession IDs
less
MGI:2444214
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:66028 Mirkina II, et al., [Cloning and study of novel mammalian genes with structural homology with phage lysozyme]. Genetika. 2000 Nov;36(11):1492-500
  • Latest
    J:252399 Dziarski R, et al., Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice. PLoS One. 2016;11(1):e0146162
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory