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Pglyrp2
Gene Detail
Symbol

Name
ID
Pglyrp2
peptidoglycan recognition protein 2
MGI:1928099
Synonyms
C730002N09Rik, Pglyrpl, PGRP-L, tagL, tagL-alpha, tagl-beta
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:32413100-32424167 bp, - strand
From Ensembl annotation of GRCm38

  11068 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49671  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PGLYRP2
Gene Tree: Pglyrp2

Human
homologs
PGLYRP2, peptidoglycan recognition protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 114770
neXtProt AC: NX_Q96PD5

Human Synonyms: HMFT0141, PGLYRPL, PGRPL, PGRP-L, tagL, tagL-alpha, tagl-beta, TAGL-like

Human Chr (Location): 19p13.12; chr19:15468645-15479504 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis.
 
Interactions
Pglyrp2 interacts with 71 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process defense response to Gram-positive bacterium, detection of bacterium, ...
Component extracellular exosome, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pglyrp2 ; ZFIN pglyrp2    NEW 
Molecular
reagents
All nucleic(33) cDNA(33)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000079563 (Evidence)
Entrez Gene 57757 (Evidence)
UniGene 86752
DFCI TC1638682, TC1612961, TC1596526, TC1630005, TC1595261, TC1583520
DoTS DT.87050035, DT.102556198, DT.101724770, DT.102556196, DT.102556197, DT.94188923, DT.99567287
NIA Mouse Gene Index U037666
EC 3.5.1.28
Consensus CDS Project CCDS37557.1
International Mouse Phenotyping Consortium Status Pglyrp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079563 Ensembl Gene Model | MGI Sequence Detail 11068 C57BL/6J ±  kb
transcript ENSMUST00000170392 Ensembl | MGI Sequence Detail 2068 Not Applicable 
polypeptide ENSMUSP00000129964 Ensembl | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(21) UniProt(7)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002502 N-acetylmuramoyl-L-alanine amidase domain
InterPro IPR015510 Peptidoglycan recognition protein
InterPro IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
Protein Ontology PR:000012611 N-acetylmuramoyl-L-alanine amidase
References
(Earliest) J:66028 Mirkina II, et al., [Cloning and study of novel mammalian genes with structural homology with phage lysozyme]. Genetika. 2000 Nov;36(11):1492-500
(Latest) J:186653 Lee J, et al., Role of Mouse Peptidoglycan Recognition Protein PGLYRP2 in the Innate Immune Response to Salmonella enterica Serovar Typhimurium Infection In Vivo. Infect Immun. 2012 Aug;80(8):2645-54
All references(34)
Other
accession IDs
MGI:2444214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory