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Pglyrp2 Gene Detail
Summary
  • Symbol
    Pglyrp2
  • Name
    peptidoglycan recognition protein 2
  • Synonyms
    C730002N09Rik, Pglyrpl, PGRP-L, tagL, tagL-alpha, tagl-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928099
    NCBI Gene: 57757
  • Gene Overview
    MyGene.info: PGLYRP2
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32412459-32424167 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928099
 protein coding gene Chr17:32412459-32424183 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023505
 protein coding gene Chr17:32251675-32264208 (-)
A/J MGP_AJ_G0023462
 protein coding gene Chr17:31179482-31191060 (-)
AKR/J MGP_AKRJ_G0023428
 protein coding gene Chr17:31465293-31475854 (-)
BALB/cJ MGP_BALBcJ_G0023467
 protein coding gene Chr17:31272598-31284202 (-)
C3H/HeJ MGP_C3HHeJ_G0023229
 protein coding gene Chr17:31863117-31873589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023910
 protein coding gene Chr17:33342415-33355843 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021384
 protein coding gene Chr17:28281324-28291215 (-)
CAST/EiJ MGP_CASTEiJ_G0022730
 protein coding gene Chr17:31917338-31927831 (-)
CBA/J MGP_CBAJ_G0023204
 protein coding gene Chr17:34805639-34821493 (-)
DBA/2J MGP_DBA2J_G0023334
 protein coding gene Chr17:30554971-30564382 (-)
FVB/NJ MGP_FVBNJ_G0023304
 protein coding gene Chr17:30381778-30393819 (-)
LP/J MGP_LPJ_G0023412
 protein coding gene Chr17:32466537-32478519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023322
 protein coding gene Chr17:33870509-33888460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023952
 protein coding gene Chr17:31829573-31840823 (-)
PWK/PhJ MGP_PWKPhJ_G0022479
 protein coding gene Chr17:29449711-29459164 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022298
 protein coding gene Chr17:29847453-29857820 (-)
WSB/EiJ MGP_WSBEiJ_G0022792
 protein coding gene Chr17:31809968-31824704 (-)



Homology
more
  • Human Ortholog
    PGLYRP2, peptidoglycan recognition protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PGLYRP2, peptidoglycan recognition protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMFT0141, PGLYRPL, PGRPL, PGRP-L, tagL, tagL-alpha, tagl-beta, TAGL-like
  • Links
    NCBI Gene ID: 114770
    neXtProt AC: NX_Q96PD5
    UniProt: Q96PD5

  • Chr Location
    19p13.12; chr19:15468645-15479504 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    94
  • Tissues
    94
  • cDNA Data
    34
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079563 Ensembl Gene Model | MGI Sequence Detail 11709 C57BL/6J ±  kb
    transcript ENSMUST00000236386 Ensembl | MGI Sequence Detail 2817 Not Applicable  
    polypeptide ENSMUSP00000158365 Ensembl | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000012611 N-acetylmuramoyl-L-alanine amidase
      (term hierarchy)
    • EC
      3.5.1.28
    • InterPro Domains
      IPR002502 N-acetylmuramoyl-L-alanine amidase domain
      IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
      IPR015510 Peptidoglycan recognition protein
      IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2444214
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:66028 Mirkina II, et al., [Cloning and study of novel mammalian genes with structural homology with phage lysozyme]. Genetika. 2000 Nov;36(11):1492-500
    • Latest
      J:252399 Dziarski R, et al., Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice. PLoS One. 2016;11(1):e0146162
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/08/2019
    MGI 6.14     		The Jackson Laboratory