Pglyrp2
Gene Detail

Symbol Name ID

Pglyrp2 peptidoglycan recognition protein 2 MGI:1928099

Synonyms

C730002N09Rik, Pglyrpl, PGRP-L, tagL, tagL-alpha, tagl-beta

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:32413100-32420975 bp, - strand From NCBI annotation of GRCm38   7876 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49671  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Pglyrp2

Human homologs

Human Homolog		PGLYRP2, peptidoglycan recognition protein 2
NCBI Gene ID		114770
neXtProt AC		NX_Q96PD5
Human Synonyms		HMFT0141, PGLYRPL, PGRPL, PGRP-L, tagL, tagL-alpha, tagl-beta, TAGL-like
Human Chr (Location)		19p13.12; chr19:15468645-15479504 (-)  GRCh38

Alleles and phenotypes

All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	defense response to Gram-positive bacterium, detection of bacterium, ...
Component	extracellular region, extracellular vesicular exosome, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(33)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000079563 (Evidence)
Entrez Gene	57757 (Evidence)
UniGene	86752
DFCI	TC1583520, TC1595261, TC1596526, TC1612961, TC1630005, TC1638682
DoTS	DT.101724770, DT.102556196, DT.102556197, DT.102556198, DT.87050035, DT.94188923, DT.99567287
NIA Mouse Gene Index	U037666
EC	3.5.1.28
Consensus CDS Project	CCDS37557.1
International Mouse Knockout Project Status	Pglyrp2

Sequences

Length	Strain/Species
genomic	57757	NCBI Gene Model | MGI Sequence Detail	7876	C57BL/6J
transcript	NM_001271476	RefSeq | MGI Sequence Detail	2817	Not Specified
polypeptide	Q8VCS0	UniProt | EBI | MGI Sequence Detail	530	Not Applicable

All sequences(62) RefSeq(21) UniProt(7)

Polymorphisms

SNPs within 2kb(22 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002502	N-acetylmuramoyl-L-alanine amidase domain
InterPro	IPR015510	Peptidoglycan recognition protein
InterPro	IPR006619	Peptidoglycan recognition protein family domain, metazoa/bacteria
Protein Ontology	PR:000012611	N-acetylmuramoyl-L-alanine amidase

Graphical View of Protein Domain Structure

References

(Earliest) J:66028 Mirkina II, et al., [Cloning and study of novel mammalian genes with structural homology with phage lysozyme]. Genetika. 2000 Nov;36(11):1492-500
(Latest) J:186653 Lee J, et al., Role of Mouse Peptidoglycan Recognition Protein PGLYRP2 in the Innate Immune Response to Salmonella enterica Serovar Typhimurium Infection In Vivo. Infect Immun. 2012 Aug;80(8):2645-54
All references(35)

Other accession IDs

MGI:2444214