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Pglyrp2
Gene Detail
Symbol

Name
ID
Pglyrp2
peptidoglycan recognition protein 2
MGI:1928099
Synonyms
C730002N09Rik, Pglyrpl, PGRP-L, tagL, tagL-alpha, tagl-beta
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:32413100-32424167 bp, - strand
From Ensembl annotation of GRCm38

  11068 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49671  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Pglyrp2

Human
homologs
Human Homolog PGLYRP2, peptidoglycan recognition protein 2
NCBI Gene ID 114770
neXtProt AC  NX_Q96PD5
Human Synonyms  HMFT0141, PGLYRPL, PGRPL, PGRP-L, tagL, tagL-alpha, tagl-beta, TAGL-like
Human Chr (Location)  19p13.12; chr19:15468645-15479504 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis.
 
Interactions
Pglyrp2 interacts with 71 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process defense response to Gram-positive bacterium, detection of bacterium, ...
Component extracellular region, extracellular vesicular exosome, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(33)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000079563 (Evidence)
Entrez Gene57757 (Evidence)
UniGene86752
DFCITC1595261, TC1583520, TC1596526, TC1612961, TC1630005, TC1638682
DoTSDT.99567287, DT.94188923, DT.102556197, DT.102556198, DT.87050035, DT.102556196, DT.101724770
NIA Mouse Gene IndexU037666
EC3.5.1.28
Consensus CDS ProjectCCDS37557.1
International Mouse Knockout Project StatusPglyrp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079563 Ensembl Gene Model | MGI Sequence Detail 11068 C57BL/6J ±  kb
transcript ENSMUST00000170392 Ensembl | MGI Sequence Detail 2068 Not Applicable 
polypeptide ENSMUSP00000129964 Ensembl | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(21) UniProt(13)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002502 N-acetylmuramoyl-L-alanine amidase domain
InterPro IPR015510 Peptidoglycan recognition protein
InterPro IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
Protein Ontology PR:000012611 N-acetylmuramoyl-L-alanine amidase
References
(Earliest) J:66028 Mirkina II, et al., [Cloning and study of novel mammalian genes with structural homology with phage lysozyme]. Genetika. 2000 Nov;36(11):1492-500
(Latest) J:186653 Lee J, et al., Role of Mouse Peptidoglycan Recognition Protein PGLYRP2 in the Innate Immune Response to Salmonella enterica Serovar Typhimurium Infection In Vivo. Infect Immun. 2012 Aug;80(8):2645-54
All references(35)
Other
accession IDs
MGI:2444214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory