Tspan3 MGI Mouse Gene Detail - MGI:1928098

Symbol

Tspan3
Name

tetraspanin 3
Synonyms

1700055K04Rik, tetraspanin, tetraspanin TM4-A homolog, TM4-A, Tm4sf8, Tspan-3

Feature Type

protein coding gene
IDs

MGI:1928098
NCBI Gene: 56434
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:56043168-56068354 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 30.13 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

707 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928098	protein coding gene	Chr9:56039009-56072761 (-)
129S1/SvImJ	ENSMUSG00200032956	protein coding gene	Chr9:53156197-53188527 (-)
A/J	ENSMUSG00195040494	protein coding gene	Chr9:52854825-52887143 (-)
AKR/J	ENSMUSG00220026257	protein coding gene	Chr9:52992047-53024359 (-)
BALB/cJ	ENSMUSG00180018068	protein coding gene	Chr9:52979867-53011925 (-)
C3H/HeJ	ENSMUSG00175020549	protein coding gene	Chr9:52981725-53014038 (-)
C57BL/6NJ	ENSMUSG00215030293	protein coding gene	Chr9:52973246-53005305 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032251	protein coding gene	Chr9:52832815-52857885 (-)
CAST/EiJ	ENSTCUG00005018794	protein coding gene	Chr9:52871624-52904748 (-)
CBA/J	ENSMUSG00210032062	protein coding gene	Chr9:53080898-53112966 (-)
DBA/2J	ENSMUSG00185037426	protein coding gene	Chr9:53112187-53144523 (-)
FVB/NJ	ENSMUSG00205028972	protein coding gene	Chr9:53424510-53456843 (-)
JF1/MsJ	ENSUMUG00000045289	protein coding gene	Chr9:53132932-53164966 (-)
LP/J	ENSMUSG00230034660	protein coding gene	Chr9:53356144-53388471 (-)
NOD/ShiLtJ	ENSMUSG00190029073	protein coding gene	Chr9:53179970-53212526 (-)
NZO/HlLtJ	ENSMUSG00225026965	protein coding gene	Chr9:53393167-53425500 (-)
PWK/PhJ	ENSLUMG00010037657	protein coding gene	Chr9:53092860-53124812 (-)
SPRET/EiJ	ENSMSPG00010023463	protein coding gene	Chr9:54127780-54159062 (-)
WSB/EiJ	ENSIUOG00005037403	protein coding gene	Chr9:52589692-52622030 (-)

Human Ortholog

TSPAN3, tetraspanin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPAN3, tetraspanin 3
Synonyms

TM4-A, TM4SF8, TSPAN-3
Links

HGNC:17752

NCBI Gene ID: 10099

UniProt: O60637
Chr Location

15q24.3; chr15:77041404-77083984 (-) GRCh38

MGI Vertebrate Homology

Tspan3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TSPAN3
Protein SuperFamily

Tetraspanin
Gene Tree

Tspan3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased hematopoietic stem cell number and decreased leukemia incidence.

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

24
cDNA Data

213
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tspan3

ZFIN tspan3a, tspan3b

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All Sequences

91
RefSeq

2
UniProt

11
CCDS

CCDS23207.1

Ensembl

ENSMUSG00000032324 (Evidence)
NCBI Gene

56434

			Length	Strain/Species	Flank
genomic	56434	NCBI Gene Model \| MGI Sequence Detail	25187	C57BL/6J	± kb
transcript	NM_019793	RefSeq \| MGI Sequence Detail	1747	C57BL/6
polypeptide	Q9QY33	UniProt \| EBI \| MGI Sequence Detail	253	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000016746 tetraspanin-3

(term hierarchy)
InterPro Domains

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

Q9QY33 4 sites, 14 N-linked glycans (3 sites)

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All nucleic 214

cDNA 213

Other 1

Antibodies 1

Microarray probesets 3

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MGI:1920663

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 9
Earliest

J:64920 Todd SC, et al., Sequences and expression of six new members of the tetraspanin/TM4SF family. Biochim Biophys Acta. 1998 Jul 30;1399(1):101-4
Latest

J:380159 Pan Y, et al., CircTspan3 Promotes Cartilage Development Through ANNEXIN A2-Mediated Ferroptosis and Apoptosis Inhibition and Exosome-Mediated Paracrine Signaling. Adv Sci (Weinh). 2026 Feb;13(10):e13418

TSS for Tspan3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2883	Chr9:56068376-56068381 (-)	-25 bp
Tssr89697	Chr9:56068335-56068359 (-)	7 bp
Tssr89696	Chr9:56068282-56068329 (-)	48 bp
Tssr89695	Chr9:56068224-56068252 (-)	116 bp
Tssr89694	Chr9:56063146-56063148 (-)	5,207 bp
Tssr89693	Chr9:56052560-56052568 (-)	15,790 bp
Tssr89692	Chr9:56046668-56046669 (-)	21,685 bp
Tssr89691	Chr9:56043744-56043801 (-)	24,581 bp
Tssr89690	Chr9:56043655-56043674 (-)	24,689 bp
Tssr89689	Chr9:56043634-56043644 (-)	24,715 bp
Tssr89688	Chr9:56043529-56043570 (-)	24,804 bp
Tssr89687	Chr9:56043421-56043437 (-)	24,925 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24