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Tspan4 Gene Detail
Summary
  • Symbol
    Tspan4
  • Name
    tetraspanin 4
  • Synonyms
    D130042I01Rik, NAG-2, novel antigen 2, Tm4sf7, Tspan-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928097
    NCBI Gene: 64540
  • Gene Overview
    MyGene.info: TSPAN4
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141475240-141493427 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928097
protein coding gene Chr7:141475236-141493427 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033236
protein coding gene Chr7:146668507-146686096 (+)
A/J MGP_AJ_G0033217
protein coding gene Chr7:142472526-142492045 (+)
AKR/J MGP_AKRJ_G0033150
protein coding gene Chr7:146424533-146442209 (+)
BALB/cJ MGP_BALBcJ_G0033218
protein coding gene Chr7:142217635-142235073 (+)
C3H/HeJ MGP_C3HHeJ_G0032933
protein coding gene Chr7:146159857-146180128 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033730
protein coding gene Chr7:152019640-152037949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030703
protein coding gene Chr7:143680605-143699969 (+)
CAST/EiJ MGP_CASTEiJ_G0032263
protein coding gene Chr7:138473695-138524088 (+)
CBA/J MGP_CBAJ_G0032905
protein coding gene Chr7:157179309-157198944 (+)
DBA/2J MGP_DBA2J_G0033057
protein coding gene Chr7:140417969-140436279 (+)
FVB/NJ MGP_FVBNJ_G0033010
protein coding gene Chr7:140332963-140350905 (+)
LP/J MGP_LPJ_G0033152
protein coding gene Chr7:148161003-148179936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033043
protein coding gene Chr7:157813851-157831369 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033749
protein coding gene Chr7:145383286-145400737 (+)
PWK/PhJ MGP_PWKPhJ_G0031967
protein coding gene Chr7:133702883-133748942 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031813
protein coding gene Chr7:132213564-132233517 (+)
WSB/EiJ MGP_WSBEiJ_G0032373
protein coding gene Chr7:146331853-146349421 (+)



Homology
more
  • Human Ortholog
    TSPAN4, tetraspanin 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TSPAN4, tetraspanin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NAG2, NAG-2, TETRASPAN, TM4SF7, TSPAN-4
  • Links
    NCBI Gene ID: 7106
    neXtProt AC: NX_O14817
    UniProt: O14817

  • Chr Location
    11p15.5; chr11:842824-867116 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025511 Ensembl Gene Model | MGI Sequence Detail 18188 C57BL/6J ±  kb
transcript ENSMUST00000026585 Ensembl | MGI Sequence Detail 1466 Not Applicable  
polypeptide ENSMUSP00000026585 Ensembl | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141916, MGI:2142025, MGI:2441940
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:44052 Tachibana I, et al., NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. J Biol Chem. 1997 Nov 14;272(46):29181-9
  • Latest
    J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory