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Mlxipl
Gene Detail
 Symbol
Name
ID
Mlxipl
MLX interacting protein-like
MGI:1927999
Synonyms bHLHd14, ChREBP, Wbscr14, WS-bHLH
Feature Type protein coding gene
Genetic Map
Chromosome 5
75.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:135106891-135138382 bp, + strand
From VEGA annotation of GRCm38

  31492 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32507  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mlxipl

Human
homologs
Human Homolog MLXIPL, MLX interacting protein-like
NCBI Gene ID 51085
neXtProt AC  NX_Q9NP71
Human Synonyms  bHLHd14, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH
Human Chr (Location)  7q11.23; chr7:73593194-73624573 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MLXIPL
Alleles
and
phenotypes
All alleles(6) : Targeted(5) Gene trapped(1)
 
Mice homozygous for a knock-out allele exhibit reduced glycolysis and lipogenesis and severe simple carbohydrate intolerance.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process glucose homeostasis, glucose mediated signaling pathway, ...
Component cytoplasm, nucleus, ...
Function carbohydrate response element binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (202)    Tissues (154)    Images (30)
Theiler Stages: 15, 17, 18, 19, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 196
RT-PCR 6
cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) Genomic(5) cDNA(26) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025974 (Evidence)
Ensembl Gene ModelENSMUSG00000005373 (Evidence)
Entrez Gene58805 (Evidence)
UniGene34213
DFCITC1583487, TC1594878, TC1596125
DoTSDT.490476, DT.101369856, DT.110638036, DT.110638042, DT.91338820, DT.99856345, DT.99856347
NIA Mouse Gene IndexU006277
PDB4GNT
Consensus CDS ProjectCCDS39316.1
International Mouse Knockout Project StatusMlxipl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025974 VEGA Gene Model | MGI Sequence Detail 31492 C57BL/6J ±  kb
transcript OTTMUST00000064065 VEGA | MGI Sequence Detail 3638 Not Applicable 
polypeptide OTTMUSP00000031771 VEGA | MGI Sequence Detail 864 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(27) UniProt(5)
Polymorphisms PCR(2) : SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010460 Williams-Beuren syndrome chromosomal region 14 protein
References (Earliest) J:61965 de Luis O, et al., WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog. Eur J Hum Genet. 2000 Mar;8(3):215-22
(Latest) J:196242 Noordeen NA, et al., Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic beta-cells. Diabetes. 2012 Mar;61(3):574-85
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory