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Mlxipl Gene Detail
Summary
  • Symbol
    Mlxipl
  • Name
    MLX interacting protein-like
  • Synonyms
    bHLHd14, ChREBP, Wbscr14, WS-bHLH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927999
    NCBI Gene: 58805
  • Gene Overview
    MyGene.info: MLXIPL
Location & Maps
more
  • Sequence Map
    Chr5:135089890-135138382 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48493 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.00 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MLXIPL, MLX interacting protein like
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MLXIPL, MLX interacting protein like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHd14, CHREBP, MIO, MLX, MONDOB, WBSCR14, WS-bHLH
  • Links
    NCBI Gene ID: 51085
    neXtProt AC: NX_Q9NP71

  • Chr Location
    7q11.23; chr7:73593194-73624540 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MLXIPL associations

Human Disease Mouse Models
       Williams-Beuren Syndrome; WBS   OMIM: 194050
Click on a disease name to see all genes associated with that disease.

  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    2
  • Targeted
    7
  • Genomic Mutations
    2 involving Mlxipl
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced glycolysis and lipogenesis and severe simple carbohydrate intolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025974 VEGA Gene Model | MGI Sequence Detail 48493 C57BL/6J ±  kb
transcript OTTMUST00000064065 VEGA | MGI Sequence Detail 3622 Not Applicable  
polypeptide OTTMUSP00000031771 VEGA | MGI Sequence Detail 864 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    147 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000010460 carbohydrate-responsive element-binding protein
  • PDB
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 35
    Genomic 5
    cDNA 26
    Primer pair 3
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 69
    Developmental Gene Expression 15
    Diseases 3
    Gene Ontology 10
    Phenotypes 20
  • Earliest
    J:61965 de Luis O, et al., WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog. Eur J Hum Genet. 2000 Mar;8(3):215-22
  • Latest
    J:228474 Wu W, et al., Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation. Biochem Biophys Res Commun. 2015 Jun 12;461(4):681-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory