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Sep15 Gene Detail
Summary
  • Symbol
    Sep15
  • Name
    selenoprotein 15
  • Synonyms
    9430015P09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927947
    NCBI Gene: 93684
  • Gene Overview
    MyGene.info: SEP15
Location & Maps
more
  • Sequence Map
    Chr3:144570304-144597680 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27377 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 68.94 cM, cytoband H3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SEP15, 15 kDa selenoprotein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEP15, 15 kDa selenoprotein
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 9403
    neXtProt AC: NX_O60613

  • Chr Location
    1p31; chr1:86862445-86914424 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3145
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SEP15
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    23
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Sep15
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit mild oxidative stress in the liver and develop cataracts by 1.5 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021251 VEGA Gene Model | MGI Sequence Detail 27377 C57BL/6J ±  kb
transcript OTTMUST00000050336 VEGA | MGI Sequence Detail 1514 Not Applicable  
polypeptide OTTMUSP00000023487 VEGA | MGI Sequence Detail 162 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    252 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR014912 Sep15/SelM redox
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924524
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:46968 Gladyshev VN, et al., A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem. 1998 Apr 10;273(15):8910-5
  • Latest
    J:195557 Tsuji PA, et al., Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. PLoS One. 2012;7(12):e50574

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory