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Mmp19
Gene Detail
Symbol

Name
ID
Mmp19
matrix metallopeptidase 19
MGI:1927899
Feature Type
protein coding gene
Genetic Map
Chromosome 10
77.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:128790953-128800824 bp, + strand
From Ensembl annotation of GRCm38

  9872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MMP19
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp19

Human
homologs
MMP19, matrix metallopeptidase 19
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4327
neXtProt AC: NX_Q99542

Human Synonyms: MMP18, RASI-1

Human Chr (Location): 12q14; chr12:55835430-55842983 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele develop diet-induced obesity due to adipocyte hypertrophy and display decreased incidence of chemically-induced fibrosarcomas while another knock-out mutant shows a reduced inflammatory reaction to contact hypersensitivity and abnormal T cell differentiation.
 
Interactions
Mmp19 interacts with 246 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process angiogenesis, cell differentiation, ...
Component anchored component of membrane, extracellular matrix, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 8
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mmp19    NEW 
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025355 (Evidence)
Entrez Gene 58223 (Evidence)
UniGene 131266
NIA Mouse Gene Index U012197
EC 3.4.24.-
Consensus CDS Project CCDS24292.1
International Mouse Phenotyping Consortium Status Mmp19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025355 Ensembl Gene Model | MGI Sequence Detail 9872 C57BL/6J ±  kb
transcript ENSMUST00000026411 Ensembl | MGI Sequence Detail 3410 Not Applicable 
polypeptide ENSMUSP00000026411 Ensembl | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010478 matrix metalloproteinase-19
References
(Earliest) J:65466 Mueller MS, et al., The murine ortholog of matrix metalloproteinase 19: its cloning, gene organization, and expression. Gene. 2000 Oct 3;256(1-2):101-11
(Latest) J:213098 Tocchi A, et al., Functional interactions between matrix metalloproteinases and glycosaminoglycans. FEBS J. 2013 May;280(10):2332-41
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory