About   Help   FAQ
Mmp19
Gene Detail
 Symbol
Name
ID
Mmp19
matrix metallopeptidase 19
MGI:1927899
Feature Type protein coding gene
Genetic Map
Chromosome 10
77.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:128790953-128800824 bp, + strand
From Ensembl annotation of GRCm38

  9872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp19

Human
homologs
Human Homolog MMP19, matrix metallopeptidase 19
NCBI Gene ID 4327
neXtProt AC  NX_Q99542
Human Synonyms  MMP18, RASI-1
Human Chr (Location)  12q14; chr12:55835430-55842983 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele develop diet-induced obesity due to adipocyte hypertrophy and display decreased incidence of chemically-induced fibrosarcomas while another knock-out mutant shows a reduced inflammatory reaction to contact hypersensitivity and abnormal T cell differentiation.
 
Interactions
Mmp19 interacts with 247 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process angiogenesis, cell differentiation, ...
Component anchored component of membrane, extracellular matrix, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (8)   
Theiler Stages: 28
Assay TypeResults
Northern blot 8
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025355 (Evidence)
Entrez Gene58223 (Evidence)
UniGene131266
NIA Mouse Gene IndexU012197
EC3.4.24.-
Consensus CDS ProjectCCDS24292.1
International Mouse Knockout Project StatusMmp19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025355 Ensembl Gene Model | MGI Sequence Detail 9872 C57BL/6J ±  kb
transcript ENSMUST00000026411 Ensembl | MGI Sequence Detail 3410 Not Applicable 
polypeptide ENSMUSP00000026411 Ensembl | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010478 matrix metalloproteinase-19
References (Earliest) J:65466 Mueller MS, et al., The murine ortholog of matrix metalloproteinase 19: its cloning, gene organization, and expression. Gene. 2000 Oct 3;256(1-2):101-11
(Latest) J:191939 Jirouskova M, et al., Hepatoprotective effect of MMP-19 deficiency in a mouse model of chronic liver fibrosis. PLoS One. 2012;7(10):e46271
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory