Mmp19
Gene Detail

Symbol Name ID

Mmp19 matrix metallopeptidase 19 MGI:1927899

Feature Type

protein coding gene

Genetic Map

Chromosome 10

77.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:128790953-128800824 bp, + strand From Ensembl annotation of GRCm38   9872 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp19

Human homologs

Human Homolog		MMP19, matrix metallopeptidase 19
NCBI Gene ID		4327
neXtProt AC		NX_Q99542
Human Synonyms		MMP18, RASI-1
Human Chr (Location)		12q14; chr12:56229214-56236735 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele develop a diet-induced obesity due to adipocyte hypertrophy and display decreased incidence of chemically-induced fibrosarcomas.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	angiogenesis, cell differentiation, ...
Component	anchored to membrane, extracellular matrix, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (8)   
Theiler Stages: 28

Assay Type	Results
Northern blot	8

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000025355 (Evidence)
Entrez Gene	58223 (Evidence)
NIA Mouse Gene Index	U012197
EC	3.4.24.-
Consensus CDS Project	CCDS24292.1
International Mouse Knockout Project Status	Mmp19

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025355	Ensembl Gene Model | MGI Sequence Detail	9872	C57BL/6J
transcript	ENSMUST00000026411	Ensembl | MGI Sequence Detail	3410	Not Applicable
polypeptide	ENSMUSP00000026411	Ensembl | MGI Sequence Detail	527	Not Applicable

All sequences(27) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018486	Hemopexin/matrixin, conserved site
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010478	matrix metalloproteinase-19

References

(Earliest) J:65466 Mueller MS, et al., The murine ortholog of matrix metalloproteinase 19: its cloning, gene organization, and expression. Gene. 2000 Oct 3;256(1-2):101-11
(Latest) J:191939 Jirouskova M, et al., Hepatoprotective effect of MMP-19 deficiency in a mouse model of chronic liver fibrosis. PLoS One. 2012;7(10):e46271
All references(33)