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Pex14 Gene Detail
Summary
  • Symbol
    Pex14
  • Name
    peroxisomal biogenesis factor 14
  • Synonyms
    Pex14p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927868
    NCBI Gene: 56273
Location & Maps
more
  • Sequence Map
    Chr4:148960535-149099876 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      139342 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PEX14, peroxisomal biogenesis factor 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEX14, peroxisomal biogenesis factor 14
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ734G22.2, NAPP2, PBD13A, Pex14p
  • Links
    NCBI Gene ID: 5195
    neXtProt AC: NX_O75381

  • Chr Location
    1p36.22; chr1:10474946-10630758 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37936
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PEX14
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PEX14 associations

Human Disease Mouse Models
       Peroxisome Biogenesis Disorder 13a (zellweger); PBD13A   OMIM: 614887
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    141
  • Gene trapped
    139
  • Targeted
    2
  • Genomic Mutations
    1 involving Pex14
  • Incidental Mutations
Homozygous disruption of this locus results in embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010943 VEGA Gene Model | MGI Sequence Detail 139342 C57BL/6J ±  kb
transcript OTTMUST00000025663 VEGA | MGI Sequence Detail 2006 Not Applicable  
polypeptide OTTMUSP00000011762 VEGA | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    978 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012560 peroxisomal membrane protein PEX14
  • InterPro Domains
    IPR025655 Peroxisomal membrane protein 14
    IPR006785 Peroxisome membrane anchor protein Pex14p, N-terminal
Molecular
Reagents
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  • All nucleic 94
    cDNA 94

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140717
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:180632 Ahlemeyer B, et al., Deletion of a single allele of the Pex11beta gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain. Dis Model Mech. 2012 Jan;5(1):125-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory