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Pex14 Gene Detail
Summary
  • Symbol
    Pex14
  • Name
    peroxisomal biogenesis factor 14
  • Synonyms
    Pex14p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927868
    NCBI Gene: 56273
  • Gene Overview
    MyGene.info: PEX14
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148960535-149099812 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    943 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927868
protein coding gene Chr4:148960535-149099876 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029132
protein coding gene Chr4:152742016-152904193 (-)
A/J MGP_AJ_G0029097
protein coding gene Chr4:146401460-146542150 (-)
AKR/J MGP_AKRJ_G0029045
protein coding gene Chr4:150402210-150551955 (-)
BALB/cJ MGP_BALBcJ_G0029113
protein coding gene Chr4:146910173-147050721 (-)
C3H/HeJ MGP_C3HHeJ_G0028834
protein coding gene Chr4:150959524-151111904 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029562
protein coding gene Chr4:158272321-158423982 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026808
protein coding gene Chr4:138824102-138968567 (-)
CAST/EiJ MGP_CASTEiJ_G0028247
protein coding gene Chr4:148178552-148327394 (-)
CBA/J MGP_CBAJ_G0028796
protein coding gene Chr4:162905860-163071851 (-)
DBA/2J MGP_DBA2J_G0028945
protein coding gene Chr4:146510740-146655718 (-)
FVB/NJ MGP_FVBNJ_G0028909
protein coding gene Chr4:145616999-145756885 (-)
LP/J MGP_LPJ_G0029035
protein coding gene Chr4:152699399-152851435 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028936
protein coding gene Chr4:166169277-166319634 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029594
protein coding gene Chr4:150896623-151044701 (-)
PWK/PhJ MGP_PWKPhJ_G0027967
protein coding gene Chr4:142506249-142651370 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027801
protein coding gene Chr4:145138524-145280301 (-)
WSB/EiJ MGP_WSBEiJ_G0028327
protein coding gene Chr4:151056906-151204035 (-)



Homology
more
  • Human Ortholog
    PEX14, peroxisomal biogenesis factor 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEX14, peroxisomal biogenesis factor 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ734G22.2, NAPP2, PBD13A, Pex14p
  • Links
    NCBI Gene ID: 5195
    neXtProt AC: NX_O75381
    UniProt: O75381

  • Chr Location
    1p36.22; chr1:10474946-10630758 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37936
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PEX14
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of this locus results in embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56273 NCBI Gene Model | MGI Sequence Detail 139278 C57BL/6J ±  kb
transcript NM_019781 RefSeq | MGI Sequence Detail 1973 C57BL/6  
polypeptide Q9R0A0 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012560 peroxisomal membrane protein PEX14
  • InterPro Domains
    IPR025655 Peroxisomal membrane protein 14
    IPR006785 Peroxisome membrane anchor protein Pex14p, N-terminal
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
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  • All nucleic 95
    cDNA 94
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2140717
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:180632 Ahlemeyer B, et al., Deletion of a single allele of the Pex11beta gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain. Dis Model Mech. 2012 Jan;5(1):125-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory