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Gpr85
Gene Detail
Symbol

Name
ID
Gpr85
G protein-coupled receptor 85
MGI:1927851
Synonyms
2900026B03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
5.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:13834458-13839942 bp, - strand
From VEGA annotation of GRCm38

  5485 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: probable G protein-coupled receptor 27/85/173
Gene Tree: Gpr85

Human
homologs
Human Homolog GPR85, G protein-coupled receptor 85
NCBI Gene ID 54329
neXtProt AC  NX_P60893
Human Synonyms  SREB, SREB2
Human Chr (Location)  7q31; chr7:113080413-113087778 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display a significant increase in brain weight and enhanced contextual memory in a fear-conditioning task but no additional behavioral abnormalities.
 
Interactions
Gpr85 interacts with 301 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (170)    Tissues (66)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
Northern blot 8
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022773 (Evidence)
Ensembl Gene ModelENSMUSG00000048216 (Evidence)
Entrez Gene64450 (Evidence)
DFCITC1579489, TC1715857
DoTSDT.110480491, DT.50315294
NIA Mouse Gene IndexU288282, U027053
Consensus CDS ProjectCCDS19916.1
International Mouse Knockout Project StatusGpr85
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022773 VEGA Gene Model | MGI Sequence Detail 5485 C57BL/6J ±  kb
transcript OTTMUST00000054675 VEGA | MGI Sequence Detail 3661 Not Applicable 
polypeptide OTTMUSP00000026119 VEGA | MGI Sequence Detail 370 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001650 G-protein coupled receptor 85
References
(Earliest) J:64476 Hellebrand S, et al., The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31(1). Biochim Biophys Acta. 2000 Sep 7;1493(1-2):269-72
(Latest) J:207660 Chen Q, et al., SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory. Eur J Neurosci. 2012 Sep;36(5):2597-608
All references(37)
Other
accession IDs
MGI:1920116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory