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Sp5 Gene Detail
Summary
  • Symbol
    Sp5
  • Name
    trans-acting transcription factor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927715
    NCBI Gene: 64406
Location & Maps
more
  • Sequence Map
    Chr2:70474923-70477729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2807 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 41.49 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SP5, Sp5 transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SP5, Sp5 transcription factor
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 389058
    neXtProt AC: NX_Q6BEB4

  • Chr Location
    2q31.1; chr2:170714738-170717988 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11190
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SP5
  • Gene Tree
    Sp5
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Sp5
Mice homozygous for a targeted mutation in this gene are fertile and show no overt phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033266 VEGA Gene Model | MGI Sequence Detail 2807 C57BL/6J ±  kb
transcript OTTMUST00000083412 VEGA | MGI Sequence Detail 2100 Not Applicable  
polypeptide OTTMUSP00000044828 VEGA | MGI Sequence Detail 398 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    12 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015443 transcription factor Sp5
  • InterPro Domains
    IPR030450 Transcription factor Sp1 family
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 10
    Primer pair 3
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 28
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65743 Harrison SM, et al., Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury. Dev Biol. 2000 Nov 15;227(2):358-72
  • Latest
    J:232050 Kennedy MW, et al., Sp5 and Sp8 recruit beta-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3545-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory