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Cyp4f14 Gene Detail
Summary
  • Symbol
    Cyp4f14
  • Name
    cytochrome P450, family 4, subfamily f, polypeptide 14
  • Synonyms
    1300014O15Rik, leukotriene B4 omega hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927669
    NCBI Gene: 64385
  • Gene Overview
    MyGene.info: CYP4F12
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32905071-32917342 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927669
protein coding gene Chr17:32905070-32917351 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023515
protein coding gene Chr17:32796556-32809178 (-)
A/J MGP_AJ_G0023473
protein coding gene Chr17:31703942-31716108 (-)
AKR/J MGP_AKRJ_G0023439
protein coding gene Chr17:32013261-32029358 (-)
BALB/cJ MGP_BALBcJ_G0023478
protein coding gene Chr17:31802216-31814524 (-)
C3H/HeJ MGP_C3HHeJ_G0023240
protein coding gene Chr17:32413271-32425086 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023921
protein coding gene Chr17:33918218-33931561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021395
protein coding gene Chr17:28970899-28983051 (-)
CAST/EiJ MGP_CASTEiJ_G0022741
protein coding gene Chr17:32519831-32531913 (-)
CBA/J MGP_CBAJ_G0023214
protein coding gene Chr17:35423339-35435537 (-)
DBA/2J MGP_DBA2J_G0023344
protein coding gene Chr17:31089006-31101436 (-)
FVB/NJ MGP_FVBNJ_G0023314
protein coding gene Chr17:30901757-30914252 (-)
LP/J MGP_LPJ_G0023423
protein coding gene Chr17:33015429-33029044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023333
protein coding gene Chr17:34412284-34424488 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023963
protein coding gene Chr17:32381373-32394760 (-)
PWK/PhJ MGP_PWKPhJ_G0022488
protein coding gene Chr17:30011488-30024041 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022308
protein coding gene Chr17:30353040-30369902 (-)
WSB/EiJ MGP_WSBEiJ_G0022802
protein coding gene Chr17:32395095-32408194 (-)



Homology
more
  • Human Ortholog
    CYP4F12, cytochrome P450 family 4 subfamily F member 12
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CYP4F12, cytochrome P450 family 4 subfamily F member 12
    Orthology source: HomoloGene
  • Synonyms
    CYPIVF12, F22329_1
  • Links
    NCBI Gene ID: 66002
    neXtProt AC: NX_Q9HCS2
    UniProt: Q9HCS2

  • Chr Location
    19p13.12; chr19:15673018-15698819 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced vitamin E-omega-hydroxylase activity and altered levels of tocopherols and their metabolites.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024292 Ensembl Gene Model | MGI Sequence Detail 12272 C57BL/6J ±  kb
    transcript ENSMUST00000179434 Ensembl | MGI Sequence Detail 2207 Not Applicable  
    polypeptide ENSMUSP00000136139 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914146, MGI:2147045
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65964 Kikuta Y, et al., Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. Arch Biochem Biophys. 2000 Nov 15;383(2):225-32
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory