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Cyp4f14 Gene Detail
Summary
  • Symbol
    Cyp4f14
  • Name
    cytochrome P450, family 4, subfamily f, polypeptide 14
  • Synonyms
    1300014O15Rik, leukotriene B4 omega hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927669
    NCBI Gene: 64385
  • Gene Overview
    MyGene.info: CYP4F12
Location & Maps
more
  • Sequence Map
    Chr17:32905071-32917342 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12272 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CYP4F12, cytochrome P450 family 4 subfamily F member 12
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CYP4F12, cytochrome P450 family 4 subfamily F member 12
    Orthology source: HomoloGene
  • Synonyms
    CYPIVF12, F22329_1
  • Links
    NCBI Gene ID: 66002
    neXtProt AC: NX_Q9HCS2

  • Chr Location
    19p13.1; chr19:15673018-15698819 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced vitamin E-omega-hydroxylase activity and altered levels of tocopherols and their metabolites.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024292 Ensembl Gene Model | MGI Sequence Detail 12272 C57BL/6J ±  kb
transcript ENSMUST00000179434 Ensembl | MGI Sequence Detail 2207 Not Applicable  
polypeptide ENSMUSP00000136139 Ensembl | MGI Sequence Detail 524 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 40
    cDNA 39
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1914146, MGI:2147045
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65964 Kikuta Y, et al., Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. Arch Biochem Biophys. 2000 Nov 15;383(2):225-32
  • Latest
    J:228779 Alpern D, et al., TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Elife. 2014;3:e03613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory