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Cyp4f14
Gene Detail
Symbol

Name
ID
Cyp4f14
cytochrome P450, family 4, subfamily f, polypeptide 14
MGI:1927669
Synonyms
1300014O15Rik, leukotriene B4 omega hydroxylase
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:32905071-32917342 bp, - strand
From Ensembl annotation of GRCm38

  12272 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:81872  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: cytochrome P450 CYP4B1
Gene Tree: Cyp4f14

Human
homologs
Human Homolog CYP4F12, cytochrome P450, family 4, subfamily F, polypeptide 12
NCBI Gene ID 66002
neXtProt AC  NX_Q9HCS2
Human Synonyms  CYPIVF12, F22329_1
Human Chr (Location)  19p13.1; chr19:15673018-15697194 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced vitamin E-omega-hydroxylase activity and altered levels of tocopherols and their metabolites.
 
Interactions
Cyp4f14 interacts with 54 markers (Mir10b, Mir32, Mir92-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (106)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024292 (Evidence)
Entrez Gene64385 (Evidence)
UniGene486449
DFCITC1652168, TC1580922
DoTSDT.101373034, DT.55208373, DT.94343621, DT.97409698
NIA Mouse Gene IndexU043882
EC1.14.13.30
Consensus CDS ProjectCCDS28621.1
International Mouse Knockout Project StatusCyp4f14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024292 Ensembl Gene Model | MGI Sequence Detail 12272 C57BL/6J ±  kb
transcript ENSMUST00000179434 Ensembl | MGI Sequence Detail 2207 Not Applicable 
polypeptide ENSMUSP00000136139 Ensembl | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(18) UniProt(1)
Polymorphisms
SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006249 cytochrome P450 4F14
References
(Earliest) J:65964 Kikuta Y, et al., Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. Arch Biochem Biophys. 2000 Nov 15;383(2):225-32
(Latest) J:190523 Bardowell SA, et al., Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism. J Lipid Res. 2012 Dec;53(12):2667-76
All references(36)
Other
accession IDs
MGI:1914146, MGI:2147045

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory