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Sirt3 Gene Detail
Summary
  • Symbol
    Sirt3
  • Name
    sirtuin 3
  • Synonyms
    2310003L23Rik, Sir2l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927665
    NCBI Gene: 64384
  • Gene Overview
    MyGene.info: SIRT3
Location & Maps
more
  • Sequence Map
    Chr7:140863670-140882309 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18640 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.07 cM, cytoband F4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SIRT3, sirtuin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIRT3, sirtuin 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SIR2L3
  • Links
    NCBI Gene ID: 23410
    neXtProt AC: NX_Q9NTG7

  • Chr Location
    11p15.5; chr11:215030-236362 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Sirt3
  • Incidental Mutations
Mice homozygous for one null allele exhibit increased systolic blood pressure while mice homozygous for another allele exhibit reduced ATP production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023441 VEGA Gene Model | MGI Sequence Detail 18640 C57BL/6J ±  kb
transcript OTTMUST00000056980 VEGA | MGI Sequence Detail 784 Not Applicable  
polypeptide OTTMUSP00000027444 VEGA | MGI Sequence Detail 258 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    84 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000029756 NAD-dependent protein deacetylase sirtuin-3, mitochondrial
  • EC
  • InterPro Domains
    IPR029035 DHS-like NAD/FAD-binding domain
    IPR017328 Sirtuin, class I
    IPR003000 Sirtuin family
    IPR026590 Sirtuin family, catalytic core domain
    IPR026591 Sirtuin family, catalytic core small domain
Molecular
Reagents
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  • All nucleic 12
    Genomic 1
    cDNA 9
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1916747, MGI:2142047
References
more
  • Summaries
    All 93
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 54
  • Earliest
    J:9098 Fukasawa KM, et al., Molecular evolution of mammalian lactate dehydrogenase-A genes and pseudogenes: association of a mouse processed pseudogene with a B1 repetitive sequence. Mol Biol Evol. 1986 Jul;3(4):330-42
  • Latest
    J:230048 Novgorodov SA, et al., SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22;291(4):1957-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory