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Sirt3
Gene Detail
 Symbol
Name
ID
Sirt3
sirtuin 3
MGI:1927665
Synonyms 2310003L23Rik, Sir2l3
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.07 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:140863670-140882309 bp, - strand
From VEGA annotation of GRCm38

  18640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81827  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NAD-dependent deacetylase sirtuin-2, eukaryotic type
Gene Tree: Sirt3

Human
homologs
Human Homolog SIRT3, sirtuin 3
NCBI Gene ID 23410
neXtProt AC  NX_Q9NTG7
Human Synonyms  SIR2L3
Human Chr (Location)  11p15.5; chr11:215030-236362 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele exhibit increased systolic blood pressure while mice homozygous for another allele exhibit reduced ATP production.
 
Interactions
Sirt3 interacts with 39 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process aerobic respiration, histone H3 deacetylation, ...
Component cytoplasm, membrane, ...
Function (3,5-dichlorophenylurea)acetate amidohydrolase activity, 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (17)    Tissues (13)    Images (2)
Theiler Stages: 1, 2, 3, 5, 15, 17, 19, 28
Assay TypeResults
RNA in situ 7
RT-PCR 10
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023441 (Evidence)
Ensembl Gene ModelENSMUSG00000025486 (Evidence)
Entrez Gene64384 (Evidence)
DFCITC1577260, TC1611388, TC1688331, TC1772447
NIA Mouse Gene IndexU029436
EC3.5.1.-
Consensus CDS ProjectCCDS21989.1
International Mouse Knockout Project StatusSirt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023441 VEGA Gene Model | MGI Sequence Detail 18640 C57BL/6J ±  kb
transcript OTTMUST00000056980 VEGA | MGI Sequence Detail 784 Not Applicable 
polypeptide OTTMUSP00000027444 VEGA | MGI Sequence Detail 258 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017328 NAD-dependent deacetylase sirtuin-2, sirtuin family, class I
InterPro IPR003000 Sirtuin family
InterPro IPR026590 Sirtuin family, catalytic core domain
InterPro IPR026591 Sirtuin family, catalytic core small domain
Protein Ontology PR:000029756 NAD-dependent protein deacetylase sirtuin-3, mitochondrial
References (Earliest) J:9098 Fukasawa KM, et al., Molecular evolution of mammalian lactate dehydrogenase-A genes and pseudogenes: association of a mouse processed pseudogene with a B1 repetitive sequence. Mol Biol Evol. 1986 Jul;3(4):330-42
(Latest) J:211108 Lin L, et al., Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3. PLoS One. 2014;9(1):e85636
All references(80)
Other
accession IDs
MGI:1916747, MGI:2142047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory