Sirt3
Gene Detail

Symbol Name ID

Sirt3 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) MGI:1927665

Synonyms

2310003L23Rik, Sir2l3

Feature Type

protein coding gene

Genetic Map

Chromosome 7

86.07 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:140863670-140882309 bp, - strand From VEGA annotation of GRCm38   18640 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Sirt3 ± 2 cM)

Protein SuperFamily: NAD-dependent deacetylase sirtuin-2, eukaryotic type
Gene Tree: Sirt3

Human ortholog

SIRT3 sirtuin 3 NCBI Gene ID 23410
Human Synonyms: SIR2L3
Human Chr11:215030-236362 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(12) : Targeted(6) Gene trapped(6)
 

Mice homozygous for one null allele exhibit increased systolic blood pressure while mice homozygous for another allele exhibit reduced ATP production.

 
Human Diseases Modeled Using Mouse Sirt3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	aerobic respiration, peptidyl-lysine deacetylation, ...
Component	cytoplasm, membrane, ...
Function	histone deacetylase activity (H3-K14 specific), histone deacetylase activity (H3-K9 specific), ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (17)    Images (2)
Theiler Stages: 1, 2, 3, 4, 5, 15, 17, 19, 28

Assay Type	Results
RNA in situ	7
RT-PCR	16

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023441 (Evidence)
Ensembl Gene Model	ENSMUSG00000025486 (Evidence)
Entrez Gene	64384 (Evidence)
DFCI	TC1577260, TC1611388, TC1688331, TC1772447
NIA Mouse Gene Index	U029436
EC	3.5.1.-, 3.5.1.98
Consensus CDS Project	CCDS21989.1
International Mouse Knockout Project Status	Sirt3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023441	VEGA Gene Model | MGI Sequence Detail	18640	C57BL/6J
transcript	OTTMUST00000056980	VEGA | MGI Sequence Detail	784	Not Applicable
polypeptide	OTTMUSP00000027444	VEGA | MGI Sequence Detail	258	Not Applicable

All sequences(60) RefSeq(6) UniProt(7)

Polymorphisms

SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017328	NAD-dependent deacetylase sirtuin-2, sirtuin family, class I
InterPro	IPR003000	Sirtuin family
InterPro	IPR026590	Sirtuin family, catalytic core domain
InterPro	IPR026591	Sirtuin family, catalytic core small domain

References

(Earliest) J:9098 Fukasawa KM, et al., Molecular evolution of mammalian lactate dehydrogenase-A genes and pseudogenes: association of a mouse processed pseudogene with a B1 repetitive sequence. Mol Biol Evol. 1986 Jul;3(4):330-42
(Latest) J:187672 Parker JA, et al., Integration of beta-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity. J Neurosci. 2012 Sep 5;32(36):12630-40
All references(64)

Other accession IDs

MGI:1916747, MGI:2142047